Inhibitors of HIF prolyl hydroxylase

1. A compound of formula I or a pharmaceutically acceptable salt thereof:

wherein:

Y is CH or N;

X is O, CH 2 , S, S(O), S(O) 2 , NH or N-Me;

m is 0, 1, 2 or 3;

n is 0, 1 or 2;

p is 0 or 1;

R 1 is independently selected from aryl, heterocyclyl, -Me-aryl, and -Me-heterocyclyl, said aryl and heterocyclyl are optionally substituted with 1, 2, or 3 substituents independently selected from: halogen, CF 3 , phenyl, CN, S(O) 2 R b , and heterocyclyl, wherein said phenyl and heterocyclyl are optionally substituted with 1, 2, or 3 substituents independently selected from:

CF 3 , halogen, C(O)N(R b ) 2 , N(R b ) 2 , C 1-4 alkyl, O(C 1-4 )alkyl, and CN;

R 2 is hydrogen or methyl;

R 3 and R 4 are each independently selected from hydrogen, hydroxyl, and C 1-4 alkyl, said alkyl optionally substituted with OH;

R 5 is independently selected from OH, halogen, CF 3 , OCF 3 , CN, C 1-4 alkyl, O(C 1-4 )alkyl, S(O) 2 R b , C 3-6 cycloalkyl, phenyl, and heterocyclyl, said cycloalkyl and heterocyclyl are optionally substituted with 1, 2, or 3 substituents independently selected from: OH, C 1-4 alkyl, O(C 1-4 )alkyl, S(O) 2 R b , C(O)N(R b ) 2 , and N(R b ) 2 ; and

R b is independently hydrogen or C 1-4 alkyl.

2. A compound according to claim 1 of formula II or a pharmaceutically acceptable salt thereof:

wherein:

Y is CH or N;

X is O, CH 2 , S, S(O), S(O) 2 , NH or N-Me;

m is 0, 1 or 2;

n is 0 or 1;

p is 0 or 1;

R 1 is independently selected from phenyl, -Me-phenyl, thiazolyl, -Me-thiazolyl, pyridinyl and oxazolyl, all of which are optionally substituted with 1 or 2 substituents independently selected from: Br,F, Cl, CF 3 , phenyl, CN, S(O) 2 R b , pyrazolyl, and pyridinyl, wherein said phenyl, pyrazolyl and pyridinyl are optionally substituted with 1 or 2 substituents independently selected from: CF 3 , Cl, C(O)N(R b ) 2 , N(R b ) 2 , C 1-4 alkyl, O(C 1-4 )alkyl, and CN;

R 5 is independently selected from OH, Br, F, Cl, CF 3 , OCF 3 , CN, C 1-4 alkyl, O(C 1-4 )alkyl, S(O) 2 R b , cyclopropyl, phenyl, isoxazolyl, pyrazolyl, pyrimidinyl and pyridinyl, said cyclopropy, phenyl, isoxazolyl, pyrazolyl, pyrimidinyl and pyridinyl are optionally substituted with 1 or 2 substituents independently selected from: OH, C 1-4 alkyl, O(C 1-4 )alkyl, S(O) 2 R b , C(O)N(R b ) 2 , and N(R b ) 2 ; and

R b is independently hydrogen or C 1-4 alkyl.

3. A compound which is:

2-(7-Hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Bromo-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-9-(methylsulfonyl)-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H -[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-9-methyl-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-(1,2-Dihydroxypropan-2-yl)-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(1-Hydroxy-3-oxo-6-(4-(trifluoromethyl)phenyl)-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-Bromo-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-8-(methylsulfonyl)-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Bromo-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-9-(methylsulfonyl)-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-9-methyl-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-Bromo-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-10-(methylsulfonyl)-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-10-methyl-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-bromo-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-Bromo-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-8-(methylsulfonyl)-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-Cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-8-methyl-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-10-(methylsulfonyl)-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-Cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-10-methyl-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-acetyl-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-9-(1-hydroxyethyl)-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-9-(2-hydroxypropan-2-yl)-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-cyano-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-10-(methylsulfonyl)-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-10-methyl-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-5-oxo-10-phenyl-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Cyano-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-9-(methylsulfonyl)-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-9-methyl-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-Cyano-1-hydroxy-3-oxo-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(1-Hydroxy-8-(methylsulfonyl)-3-oxo-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(1-Hydroxy-8-methyl-3-oxo-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(9-Bromo-1-hydroxy-3-oxo-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(9-Cyano-1-hydroxy-3-oxo-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(1-Hydroxy-9-(methylsulfonyl)-3-oxo-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(1-Hydroxy-3-oxo-6-(thiazol-5-yl)-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid 2-(7-Hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij][1,7]naphthyridine-6-carboxamido)acetic acid;

2-(9-Cyano-2-(4-cyanophenyl)-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino [2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Bromo-2-(4-bromophenyl)-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-Cyano-2-(4-cyanophenyl)-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino [2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-Bromo-2-(4-bromophenyl)-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-Cyano-2-(4-cyanophenyl)-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-Bromo-2-(4-bromophenyl)-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino [2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-1-oxido-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-1,1-dioxido-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;;

2-(7-hydroxy-1-oxido-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Cyano-1-hydroxy-3-oxo-6-(4-(trifluoromethyl)phenyl)-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(7-Hydroxy-8-methyl-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(7-Hydroxy-1-methyl-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(9-Fluoro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-Fluoro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-Fluoro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-fluoro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-Chloro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-chloro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-Chloro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-chloro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Chloro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-chloro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-2-(4-(methylsulfonyl)phenyl)-5-oxo-10-(trifluoromethyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(2-(4-cyanophenyl)-7-hydroxy-5-oxo-10-(trifluoromethyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(2-(4-cyanophenyl)-7-hydroxy-10-(trifluoromethyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-8-methoxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7,8-dihydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-9-methoxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7,9-Dihydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(1-Hydroxy-3-oxo-6-(6-(trifluoromethyl)pyridin-3-yl)-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(9-cyano-1-hydroxy-3-oxo-6-(6-(trifluoromethyl)pyridin-3-yl)-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(1-hydroxy-9-(methylsulfonyl)-3-oxo-6-(6-(trifluoromethyl)pyridin-3-yl)-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-8-(trifluoromethoxy)-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-5-oxo-8-(trifluoromethoxy)-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(2-(4-Cyanophenyl)-7-hydroxy-5-oxo-8-(trifluoromethoxy)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(2-(4-cyanophenyl)-7-hydroxy-5-oxo-8-(trifluoromethoxy)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Cyano-7-hydroxy-1-oxido-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(9-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(8-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(9-Cyano-7-hydroxy-1-methyl-5-oxo-3-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(9-Cyano-7-hydroxy-1-methyl-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(8-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-Fluoro-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-Cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-1,1-dioxido-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-Cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-2-(6-(trifluoromethyl)pyridin-3-yl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-1,1-dioxido-5-oxo-2-(6-(trifluoromethyl)pyridin-3-yl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-3-(thiazol-5-yl)-3,5-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(7-Hydroxy-1-methyl-5-oxo-3-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(10-Cyano-7-hydroxy-5-oxo-2-(thiazol-5-yl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-2-(thiazol-5-yl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-3-(thiazol-5-yl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(7-Hydroxy-1-methyl-5-oxo-2-(thiazol-5-yl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(7-Hydroxy-1-methyl-5-oxo-3-(thiazol-5-yl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(10-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(10-Fluoro-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(10-Fluoro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(10-Fluoro-7-hydroxy-1-methyl-5-oxo-3-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(9-Fluoro-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(8-Fluoro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(9-Fluoro-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(8-Fluoro-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(9-Fluoro-7-hydroxy-1-methyl-5-oxo-3-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(9-Fluoro-7-hydroxy-1-methyl-5-oxo-2-(4-(trifluoromethyl)phenyl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-9-(trifluoromethoxy)-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(2-(4-Cyanophenyl)-7-hydroxy-5-oxo-9-(trifluoromethoxy)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-2-(6-(trifluoromethyl)pyridin-3-yl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(7-Hydroxy-1-methyl-5-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)-1,2,3,5-tetrahydropyrido[1,2,3-de]quinoxaline-6-carboxamido)acetic acid;

2-(6-Hydroxy-4-oxo-2-phenyl-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxamido)acetic acid;

2-(1-Hydroxy-3-oxo-5-phenyl-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(5-(4-Chlorobenzyl)-1-hydroxy-3-oxo-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;

2-(7-Hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(3-(4-Bromophenyl)-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

N-[(7-Hydroxy-10-{4-[(methylsulfonyl)amino]phenyl}-5-oxo-3-[4-(trifluoromethyl)phenyl]-2,3 -dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl)carbonyl]glycine;

N-({7-hydroxy-10-(5-methoxypyridin-3-yl)-5-oxo-3-[4-(trifluoromethyl)phenyl]-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl}carbonyl)glycine;

N-({7-hydroxy-5-oxo-10-pyridin-2-yl-3-[4-(trifluoromethyl)phenyl]-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl}carbonyl)glycine;

N-({7-hydroxy-10-(2-methoxypyrimidin-5-yl)-5-oxo-3-[4-(trifluoromethyl)phenyl]-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl}carbonyl)glycine;

N-({10-(3-carbamoylphenyl)-7-hydroxy-5-oxo-3-[4-(trifluoromethyl)phenyl]-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl}carbonyl)glycine;

2-(7-hydroxy-5-oxo-10-(1H-pyrazol-5-yl)-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

N-{[3-(4′-Carbamoylbiphenyl-4-yl)-7-hydroxy-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

N-{[3-(3′-chlorobiphenyl-4-yl)-7-hydroxy-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

N-[(7-hydroxy-5-oxo-3-{4-[6-(trifluoromethyl)pyridin-3-yl]phenyl}-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl)carbonyl]glycine;

N-{[7-hydroxy-3-(4′-methylbiphenyl-4-yl)-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

N-{[7-hydroxy-3-(4′-methoxybiphenyl-4-yl)-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

N-{[3-(4′-cyanobiphenyl-4-yl)-7-hydroxy-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

N-({7-hydroxy-3-[4-(2-methoxypyridin-3-yl)phenyl]-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl}carbonyl)glycine;

N-{[7-hydroxy-5-oxo-3-(4-pyridin-4-ylphenyl)-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

N-({3-[4-(6-aminopyridin-3-yl)phenyl]-7-hydroxy-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl}carbonyl)glycine;

N-{[3-(3′-cyanobiphenyl-4-yl)-7-hydroxy-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

N-{[7-hydroxy-5-oxo-3-(4-pyridin-3-ylphenyl)-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

2-(3-(4-(1H-pyrazol-5-yl)phenyl)-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

N-[(7-Hydroxy-5-oxo-10-pyridin-3-yl-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl)carbonyl]glycine;

N-{[7-hydroxy-10-(6-methoxypyridin-3-yl)-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

N-{[10-(3,5-dimethylisoxazol-4-yl)-7-hydroxy-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

N-{[10-(6-aminopyridin-3-yl)-7-hydroxy-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinolin-6-yl]carbonyl}glycine;

2-(7-Hydroxy-5-oxo-3-(4-chlorophenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-fluoro-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-bromo-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-5-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-bromo-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-fluoro-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-3-(4-methoxyphenyl)-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-fluoro-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-chloro-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(9-chloro-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

droxy-5-oxo-3-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-5-oxo-3-(thiazol-2-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-bromo-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-bromo-7-hydroxy-5-oxo-3-(thiazol-4-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-5-oxo-3-(2-(trifluoromethyl)thiazol-5-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-fluoro-7-hydroxy-5-oxo-3-(thiazol-5-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-hydroxy-3-(oxazol-5-yl)-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-fluoro-7-hydroxy-5-oxo-3-(thiazol-5-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8,10-difluoro-7-hydroxy-5-oxo-3-(thiazol-5-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(8-bromo-7-hydroxy-5-oxo-3-(thiazol-5-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(10-bromo-7-hydroxy-5-oxo-3-(thiazol-5-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

ammonium 2-(9-cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetate;

ammonium 2-(8-cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetate;

ammonium 2-(3-(4-cyanophenyl)-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetate;

ammonium 2-(10-cyano-7-hydroxy-5-oxo-3-(thiazol-5-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetate;

ammonium 2-(7-hydroxy-9-(methylsulfonyl)-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetate;

2-(7-Hydroxy-5-oxo-9-(1H-pyrazol-5-yl)-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

2-(7-Hydroxy-10-methyl-5-oxo-3-(thiazol-4-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid; or

2-(10-Cyclopropyl-7-hydroxy-5-oxo-3-(thiazol-4-yl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;

or a pharmaceutically acceptable salt thereof.

4. A compound of formula 1 or a pharmaceutically acceptable salt thereof according to claim 1 , for use as a medicament.

5. A compound of formula 1 or a pharmaceutically acceptable salt thereof according to claim 1 , for the treatment of conditions mediated by HIF prolyl hydroxylase.

6. A pharmaceutical composition comprising a compound of formula 1 or a pharmaceutically acceptable salt thereof, and pharmaceutically acceptable carrier.