Type of extraction cell for a centrifugal partition chromatograph, as well as a centrifugal partition chromatograph containing such an extraction cell
The object of the invention relates to an extraction cell ( 100 ) used in a centrifugal partition chromatograph, which has a cell wall ( 120 ) determining a closed extraction chamber ( 150 ), as well as an inlet ( 115 ) and an outlet ( 140 ) ensuring the fluid connection between the extraction chamber ( 150 ) and the space outside of the extraction cell ( 100 ) formed on essentially opposite parts of the cell wall ( 120 ). The extraction cell ( 100 ) according to the invention is constructed asymmetrically from the point of view of the reversibility of the direction of flow used when the centrifugal partition chromatograph is in operation.
1. An extraction cell ( 100 , 200 ) for a centrifugal partition chromatograph, comprising a cell wall ( 120 , 220 ) determining a closed extraction chamber ( 150 , 250 ), as well as an inlet ( 115 , 215 ) and an outlet ( 140 , 240 ) ensuring a fluid connection between the closed extraction chamber ( 150 , 250 ) and a space outside of the extraction cell ( 100 , 200 ) formed on essentially opposite parts of the cell wall ( 120 , 220 ), wherein the extraction cell ( 100 , 200 ) has an asymmetrical structure from the point of view of reversibility of flow direction when the centrifugal partition chromatograph is in operation, and wherein the inlet ( 115 , 215 ) is formed as at least two inlet branches ( 115 a, 115 b ).
2. The extraction cell ( 100 , 200 ) according to claim 1 , wherein the inlet ( 115 , 215 ) and the outlet ( 140 , 240 ) have different cross-sections.
3. The extraction cell ( 100 , 200 ) according to claim 1 , wherein the flow cross-section of the outlet ( 140 , 240 ) is greater than the flow cross-section of the inlet ( 115 , 215 ).
4. The extraction cell ( 100 , 200 ) according to claim 1 , wherein the inlet ( 115 , 215 ) is formed as two to ten inlet branches ( 115 a, 115 b ).
5. The extraction cell ( 100 , 200 ) according to claim 1 , wherein the cell wall ( 120 , 220 ) forms an essentially rectangular based inclined prism, the angle of tilt of which, with the extraction cell ( 100 , 200 ) in its position in the centrifugal partition chromatograph, being selected to minimise the Coriolis force occurring as a result of the rotation when the extraction cell ( 100 , 200 ) is in its operation state.
6. The extraction cell ( 100 , 200 ) according to claim 5 , wherein the angle of tilt is between 5° and 30°.
7. The extraction cell ( 100 ) according to claim 1 , which is produced by fused deposition modelling 3D printing technology.
8. The extraction cell ( 200 ) according to claim 1 , wherein the collection pool ( 230 ) is formed as a part of the cell wall ( 220 ) extending in an inclined way in the direction of the outlet ( 240 ).
9. A centrifugal partition chromatograph, which contains at least one extraction cell ( 100 , 200 ) according to claim 1 .
10. The centrifugal partition chromatograph according to claim 9 , which has a modular construction realised with essentially identical modules ( 300 ), where all of the modules ( 300 ) contain more than one extraction cell ( 100 , 200 ) connected by channels ( 330 ) providing a fluid connection between said more than one extraction cell ( 100 , 200 ), furthermore the individual modules ( 300 ) are connected in series with each other via tubes ( 430 ).
11. The extraction cell ( 100 , 200 ) according to claim 5 , wherein the angle of tilt is between 15° and 18°.
12. An extraction cell ( 100 , 200 ) for a centrifugal partition chromatograph, comprising a cell wall ( 120 , 220 ) determining a closed extraction chamber ( 150 , 250 ), as well as an inlet ( 115 , 215 ) and an outlet ( 140 , 240 ) ensuring a fluid connection between the closed extraction chamber ( 150 , 250 ) and a space outside of the extraction cell ( 100 , 200 ) formed on essentially opposite parts of the cell wall ( 120 , 220 ), wherein the extraction cell ( 100 , 200 ) has an asymmetrical structure from the point of view of reversibility of flow direction used when the centrifugal partition chromatograph is in operation, and wherein the extraction chamber ( 150 , 250 ) is connected to the outlet ( 140 , 240 ) via a collection pool ( 130 , 230 ), and wherein at least one of the following conditions is satisfied:
the collection pool ( 130 ) is formed as a protruding hemispherical part of the cell wall ( 120 ), and the outlet ( 140 ) is located on this hemisphere, and/or
the collection pool ( 230 ) is formed as a part of the cell wall ( 220 ) extending in an inclined way in the direction of the outlet ( 240 ) and which extraction cell is produced by combining two half cells obtained by CNC milling, where the surfaces of the cell halves touching each other are coated with a fluoropolymer.
13. The extraction cell ( 100 ) according to claim 12 , wherein the collection pool ( 130 ) is formed as a protruding hemispherical part of the cell wall ( 120 ), and the outlet ( 140 ) is located on this hemisphere.
14. The extraction cell ( 200 ) according to claim 12 , wherein the collection pool ( 230 ) is formed as a part of the cell wall ( 220 ) extending in an inclined way in the direction of the outlet ( 240 ), and which extraction cell is produced by combining two half cells obtained by CNC milling, where the surfaces of the cell halves touching each other are coated with a fluoropolymer.
15. A centrifugal partition chromatograph, which contains at least one extraction cell ( 100 , 200 ) according to claim 12 .
16. The centrifugal partition chromatograph according to claim 15 , which has a modular construction realised with essentially identical modules ( 300 ), where all of the modules ( 300 ) contain more than one extraction cell ( 100 , 200 ) connected by channels ( 330 ) providing a fluid connection between said more than one extraction cell ( 100 , 200 ), furthermore the individual modules ( 300 ) are connected in series with each other via tubes ( 430 ).
17. An extraction cell ( 100 , 200 ) for a centrifugal partition chromatograph, comprising a cell wall ( 120 , 220 ) determining a closed extraction chamber ( 150 , 250 ), as well as an inlet ( 115 , 215 ) and an outlet ( 140 , 240 ) ensuring a fluid connection between the closed extraction chamber ( 150 , 250 ) and a space outside of the extraction cell ( 100 , 200 ) formed on essentially opposite parts of the cell wall ( 120 , 220 ), wherein the extraction cell ( 100 , 200 ) has an asymmetrical structure from the point of view of reversibility of flow direction used when the centrifugal partition chromatograph is in operation, and wherein at least a part of the surface ( 125 ) of the cell wall ( 120 ) bordering with the extraction chamber ( 150 ) is roughened.
18. The extraction cell ( 100 ) according to claim 17 , wherein the roughening is ensured by steps or saw teeth on the surface ( 125 ).
19. A centrifugal partition chromatograph, which contains at least one extraction cell ( 100 , 200 ) according to claim 17 .
20. The centrifugal partition chromatograph according to claim 19 , which has a modular construction realised with essentially identical modules ( 300 ), where all of the modules ( 300 ) contain more than one extraction cell ( 100 , 200 ) connected by channels ( 330 ) providing a fluid connection between said more than one extraction cell ( 100 , 200 ), furthermore the individual modules ( 300 ) are connected in series with each other via tubes ( 430 ).