Self-assembling tripeptides
The present invention relates to a method of predicting the propensity of tripeptides to from aggregates in solution. The present invention also provides tripeptides which are able to form aggregates in solution, as well as uses thereof. The present invention also provides nanostructures formed by self-aggregation of tripeptides of the present invention. The present invention also provides pH responsive aggregates as well as methods of screening for the ability of a tripeptide to form a pH dependent aggregate or gel.
1. A hydrogel comprising a self-aggregated tripeptide, wherein the self-aggregated tripeptide is selected from the group consisting of KFF, KFY, KFW, FYF, KYY, KYW, KWF, KWY, and KWW.
2. The hydrogel according to claim 1 , wherein the hydrogel further comprises an additional self-aggregated tripeptide selected from the group consisting of KFF, KFY, KFW, FYF, KYY, KYW, KWF, KWY, and KWW.
3. The hydrogel according to claim 1 , wherein the hydrogel is a self-supporting structure.
4. The hydrogel according to claim 1 , further comprising a pharmaceutically active agent.
5. The hydrogel according to claim 1 , wherein the self-aggregated tripeptide is present at a concentration of between 1-500 nM.
6. The hydrogel according to claim 1 , wherein the self-aggregated tripeptide is KYF.
7. The hydrogel according to claim 1 , wherein the self-aggregated tripeptide is KFF.
8. The hydrogel according to claim 1 , wherein the self-aggregated tripeptide is KYW.
9. The hydrogel according to claim 1 , wherein the self-aggregated tripeptide is KYY.