Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof

1. A compound having the structure of formula (II):

or a pharmaceutically acceptable salt thereof, wherein:

Z is —NR 9 —, —NR 9 C(O)—, or —O—C(O)—;

L 1 is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;

R 1 is phenyl substituted with a substituent group —C(O)NR 1C R 1D ;

R 1C is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

R 1D is substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

or R 1C and R 1D and the nitrogen atom they are attached to may optionally combine to form a substituted or unsubstituted heterocycloalkyl;

R 2 is substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

R 3 is hydrogen, halogen, —CX 3 3 , —CHX 3 2 , —CH 2 X 3 , —OCX 3 3 , —OCHX 3 2 , —OCH 2 X 3 , —CN, —SO n3 R 16 , —SO v3 NR 13 R 14 , —NHC(O)NR 13 R 14 , —N(O) m3 , —NR 13 R 14 , —C(O)R 15 , —C(O)—OR 15 , —C(O)NR 13 R 14 , —OR 16 , —NR 13 SO 2 R 16 , —NR 13 C(O)R 15 , —NR 13 C(O)OR 15 , —NR 13 OR 15 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

R 4 is hydrogen, halogen, —CX 4 3 , —CHX 4 2 , —CH 2 X 4 , —OCX 4 3 , —OCHX 4 2 , —OCH 2 X 4 , —CN, —SO n4 R 20 , —SO v4 NR 17 R 18 , —NHC(O)NR 17 R 18 , —N(O) m4 , —NR 17 R 18 , —C(O)R 19 , —C(O)—OR 19 , —C(O)NR 17 R 18 , —OR 20 , —NR 17 SO 2 R 20 , —NR 17 C(O)R 19 , —NR 17 C(O)OR 19 , —NR 17 OR 19 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

R 5 is hydrogen, halogen, —CX 5 3 , —CHX 5 2 , —CH 2 X 5 , —OCX 5 3 , —OCHX 5 2 , —OCH 2 X 5 , —CN, —SO n5 R 24 , —SO v5 NR 21 R 22 , —NHC(O)NR 21 R 22 , —N(O) m5 , —NR 21 R 22 , —C(O)R 23 , —C(O)—OR 23 , —C(O)NR 21 R 22 , —OR 24 , —NR 21 SO 2 R 24 , —NR 21 C(O)R 23 , —NR 21 C(O)OR 23 , —NR 21 OR 23 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

R 6 is hydrogen, halogen, —CX 6 3 , —CHX 6 2 , —CH 2 X 6 , —OCX 6 3 , —OCHX 6 2 , —OCH 2 X 6 , —CN, —SO n6 R 28 , —SO v6 NR 25 R 26 , —NHC(O)NR 25 R 26 , —N(O) m6 , —NR 25 R 26 , —C(O)R 27 , —C(O)—OR 27 , —C(O)NR 25 R 26 , —OR 28 , —NR 25 SO 2 R 28 , —NR 25 C(O)R 27 , —NR 25 C(O)OR 27 , —NR 25 OR 27 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

each R 8 , R 9 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 , R 22 , R 23 , R 24 , R 25 , R 26 , R 27 , and R 28 is independently hydrogen, —CX 3 , —CN, —COOH, —CONH 2 , —CHX 2 , —CH 2 X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

each X is independently —F, —Cl, —Br, or —I;

each X 3 , X 4 , X 5 , and X 6 is independently —F, —Cl, —Br, or —I;

each m3, m4, m5, and m6 is independently 1 or 2;

each n3, n4, n5, and n6 is independently an integer from 0 to 3; and

each v3, v4, v5, and v6 is independently 1 or 2.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein

Z is —NR 9 —;

L 1 is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; and

R 2 is independently substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein

Z is —NR 9 —;

L 1 is substituted or unsubstituted alkylene or substituted or unsubstituted arylene; and

R 2 is substituted or unsubstituted alkyl or substituted or unsubstituted heterocycloalkyl.

4. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein

Z is —NH—;

L 1 is substituted or unsubstituted C 3 -C 6 alkylene; and

R 2 is substituted or unsubstituted heterocycloalkyl.

5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein

Z is —NH—;

L 1 is substituted or unsubstituted arylene;

R 2 is C 1 -C 3 alkyl substituted with substituent group R 2A ;

R 2A is —NR 2B R 2C , substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and

each of R 2B and R 2C is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or wherein R 2B and R 2C combine to form a substituted or unsubstituted heterocycloalkyl.

6. The compound of claim 1 , having the structure of formula (II-A):

or a pharmaceutically acceptable salt thereof, wherein:

R 2 is substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl.

7. The compound of claim 1 , having the structure of formula (II-B):

or a pharmaceutically acceptable salt thereof, wherein:

L 1 is substituted or unsubstituted arylene;

R 2A is independently —NR 2B R 2C , substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and

each of R 2B and R 2C is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or wherein R 2B and R 2C combine to form a substituted or unsubstituted heterocycloalkyl.

8. The compound of claim 6 , or a pharmaceutically acceptable salt thereof, wherein

R 1 is phenyl substituted with substituent group R 1A ; and

R 1A is —C(O)NR 1C R 1D , wherein R 1A is para to the carbon attached to the quinoline moiety.

9. The compound of claim 1 , having the structure of formula (II-C):

or a pharmaceutically acceptable salt thereof, wherein:

R 1C is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and

R 1D is substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

or wherein R 1C and R 1D attached to the same nitrogen atom optionally combine to form a substituted or unsubstituted heterocycloalkyl.

10. The compound of claim 9 , or a pharmaceutically acceptable salt thereof, wherein

Z is —NR 9 —; and

L 1 is substituted or unsubstituted alkylene or substituted or unsubstituted arylene.

11. The compound of claim 10 , or a pharmaceutically acceptable salt thereof, wherein each of R 3 , R 4 , R 5 , R 6 , and R 8 is hydrogen.

12. A compound that is:

N,N-diethyl-4-(4-((3-(piperidin-1-yl)propyl)amino)quinolin-2-yl)benzamide;

phenyl-N-(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

3-[N-(4-{4-[(3-piperidylpropyl)amino]-2-quinolyl}phenyl)carbamoyl]propanoic acid;

N-(2-cyanoethyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-ethyl-N-methyl(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-(methylethyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-ethyl(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)-N-(2,2,2-trifluoroethyl)carboxamide;

N-(oxolan-2-ylmethyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

ethyl 2-[(4-{4-[(3-piperidylpropyl)amino]-2-quinolyl}phenyl)carbonylamino]acetate;

N-[2-(dimethylamino)ethyl](4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-(3-hydroxypropyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

2-[(4-{4-[(3-piperidylpropyl)amino]-2-quinolyl}phenyl)carbonylamino]acetic acid;

methyl 2-[(4-{4-[(3-piperidylpropyl)amino]-2-quinolyl}phenyl)carbonylamino]acetate;

N-cyclopropyl(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N,N-dimethyl(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-methyl(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

3-amino-5-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl morpholin-4-yl ketone;

4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl pyrrolidinyl ketone;

(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)-N-(2-(4-pyridyl)ethyl)carboxamide;

N-[3-(diethylamino)propyl](4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-(2-piperidylethyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-(3-morpholin-4-ylpropyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

piperazinyl 4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl ketone;

piperidyl 4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl ketone;

N-(3-aminopropyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-(4-piperidyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-(4-piperidylmethyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-(3-piperidylpropyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-(2-methylpropyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-(2-hydroxyethyl)(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

(2-fluoro-4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)-N-methylcarboxamide;

N-ethyl(2-fluoro-4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-cyclohexyl(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

morpholin-4-yl 4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl ketone;

N-cyclopentyl(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

(2-chloro-4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)-N-methylcarboxamide;

N-benzyl(4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

N-[2-(diethylamino)ethyl](4-{4-[(3-piperidylpropyl)amino](2-quinolyl)}phenyl)carboxamide;

or a pharmaceutically acceptable salt thereof.

13. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

14. A method of treating a disease or condition, said method comprising administering to a subject in need thereof an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and

wherein said disease or condition is diabetes, heart disease, coronary artery disease, hyperlipidemia, lipodystrophy, insulin resistance, rheumatic disease, atherosclerosis, myocardial infarction, stroke, high blood pressure (hypertension), obesity, elevated fasting plasma glucose, high serum triglycerides, elevated blood cholesterol, cardiac hypertrophy, heart failure or metabolic syndrome.