2′ and/or 5′ amino-acid ester phosphoramidate 3′-deoxy adenosine derivatives as anti- cancer compounds
Disclosed are chemical compounds, the compounds for use in a method of treatment, particularly in a method of prophylaxis or treatment for cancer, a process for preparation of the compounds and pharmaceutical compositions comprising the compounds. The compounds may, in particular, be useful in the treatment of leukaemia, lymphoma and/or solid tumours in homo sapiens . The compounds are derivatives of cordycepin (3′-deoxyadenosine) having a 2′ and/or 5′-amino-acid ester phosphoramidate moiety.
1. 3′-Deoxyadenosine-5′-O-[phenyl(benzyloxy-L-alaninyl)] phosphate:
or a pharmaceutically acceptable salt, ester, salt of an ester, or solvate thereof.
2. The compound of claim 1 , wherein the compound is 3′-Deoxyadenosine-5′-O-[phenyl(benzyloxy-L-alaninyl)] phosphate:
3. A pharmaceutical composition, comprising the compound according to claim 1 ; and a pharmaceutically acceptable excipient.
4. The pharmaceutical composition of claim 3 , wherein the compound is 3′-Deoxyadenosine-5′-O-[phenyl(benzyloxy-L-alaninyl)] phosphate: