Ethyl N-boc piperidinyl pyrazolo pyridones as Janus kinase inhibitors

1. A compound of Formula I or a pharmaceutically acceptable salt thereof:

A is selected from aryl and heteroaryl;

m is 0, 1, or 2;

R 1 is selected from hydrogen, C 1-2 alkyl, fluoro, and hydroxy;

R 2 is selected from:

hydrogen

halogen,

oxo (═O),

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

spirocyclylC 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

spiroheterocyclylC 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkylaminoC 0-10 alkyl,

(C 1-10 )heteroalkylaminoC 0-10 alkyl,

(C 1-10 )heteroalkylaminoC 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

aryl C 0-10 alkylaminoC 0-10 alkyl,

heteroaryl C 0-10 alkylaminoC 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

C 1-10 alkylsulfonyl,

C 1-10 heteroalkylsulfonyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonyl,

(C 3-12 ) heterocycloalkylC 0-10 alkylsulfonyl,

heteroarylC 0-10 alkylsulfonyl,

arylC 0-10 alkylsulfonyl,

—SO 2 NH 2 ,

—SO 2 NH(C 1-6 alkyl),

—SO 2 N(C 1-6 alkyl) 2 ,

C 1-10 heteroalkylsulfamoyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfamoyl,

(C 3-12 ) heterocycloalkylC 0-10 alkylsulfamoyl,

heteroarylC 0-10 alkylsulfamoyl,

arylC 0-10 alkylsulfamoyl,

(C 1-10 alkyl) 1-2 amino,

—CO 2 (C 0-10 alkyl),

—(C 0-10 alkyl)CO 2 H,

—SO 2 CF 3 ,

—SO 2 CF 2 H,

—SO 2 CH 2 CF 3 ,

C 1-10 alkylsulfinyl,

C 1-4 acylaminoC 0-10 alkyl,

hydroxy,

—(C 1-10 alkyl)OH,

C 1-10 alkoxyC 0-10 alkyl,

cyano,

(C 1-6 alkyl)cyano,

cyanoC 1-6 alkyl, and

C 1-6 haloalkyl;

wherein R 2 is optionally independently substituted by 0, 1, 2, or 3 R 4 ;

each R 3 independently is selected from:

C 1-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl,

C 1-10 alkoxyC 0-10 alkyl,

halogen,

C 1-6 haloalkyl, and

oxo;

each R 4 independently is selected from:

C 1-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl,

C 1-10 alkoxyC 0-10 alkyl,

C 0-10 alkylaminoC 0-10 alkyl,

halogen,

hydroxy,

—(C 1-10 alkyl)OH,

C 1-6 haloalkyl, and

oxo.

2. A compound according to claim 1 , wherein R 2 is selected from:

hydrogen

halogen,

oxo (═O),

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

spirocyclylC 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

spiroheterocyclylC 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkylaminoC 0-10 alkyl,

C 1-10 alkylsulfonyl,

(C 3-12 ) heterocycloalkylC 0-10 alkylsulfonyl,

—SO 2 NH(C 1-6 alkyl),

—SO 2 N(C 1-6 alkyl) 2 ,

—(C 0-10 alkyl)CO 2 H,

—(C 1-10 alkyl)OH,

C 1-10 alkoxyC 0-10 alkyl,

cyanoC 1-6 alkyl, and

C 1-6 haloalkyl, wherein R 2 is optionally independently substituted by 0, 1, 2, or 3 R 4 or a pharmaceutically acceptable salt thereof.

3. A compound according to claim 2 , wherein R 2 is selected from: carboxy, (8-oxa-3-azabicyclo[3.2.1]oxtane)carbonyl, cyclohexyl, piperidinyl, morpholinylcarbonyl, azepanyl, ((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptyl)carbonyl, cyanomethyl, (2-oxa-6-azaspiro[3.3]heptyl)carbonyl, thiomorpholinylcarbonyl, ((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptyl)carbonyl, (2-oxa-5-azabicyclo[2.2.1]heptyl)carbonyl, piperidinylcarbonyl pyrrolidinylcarbonyl, pyrrolidinyl, tert-butylaminomethyl, 2,2,2-trifluoroethyl, pyrrolidinylsulfonyl, fluoro, methoxymethyl, hydroxymethyl, (6-oxa-9-azaspiro[4.5]decyl)carbonyl, ((1R,5S)6-oxa-3-azabicyclo[3.1.1]heptyl)carbonyl, (6-oxa-3-azabicyclo[3.1.1]heptyl)carbonyl 1,4-thiazepanylcarbonyl, thiazepanylcarbonyl, 1,4-oxazepanylcarbonyl, oxazepanylcarbonyl, (2-oxa-5-azabixyclo[4.1.0]heptyl)carbonyl; dimethylsulfamoyl, tert-butyl, and methylsulfonyl, wherein R 2 is optionally independently substituted by 0, 1, 2, or 3 R 4 or a pharmaceutically acceptable salt thereof.

4. A compound according to claim 3 , wherein A is selected from:

isoindolinyldiyl, pyridinyldiyl,

and indolinyldiyl, or a pharmaceutically acceptable salt thereof.

5. A compound according to claim 4 , wherein R 3 independently is selected from: C 1-10 alkyl, oxo, (C 3-12 )heterocycloalkyl C 0-10 alkyl, C 1-10 alkoxyC 0-10 alkyl, halogen, and C 1-6 haloalkyl, or a pharmaceutically acceptable salt thereof.

6. A compound according to claim 5 , wherein R 3 independently is selected from: methyl, trifluoromethyl, ethyl, trifluoroethyl, fluoro, oxo, hydroxy, isopropyl, thiomorpholinyl, isobutyl, and difluoromethyl, or a pharmaceutically acceptable salt thereof.

7. A compound according to claim 6 , wherein R 1 is hydrogen, and R 4 is selected from: methyl, fluoro, 2,2,2-trifluoroethyl, trifluoromethyl, tert-butylamino, methoxy, hydroxy, oxo, isopropyl, thiomorpholinyl, and isobutyl, or a pharmaceutically acceptable salt thereof.

8. A compound of claim 1 or a pharmaceutically acceptable salt selected from:

tert-butyl 4-(3-(4-(N,N-dimethylsulfamoyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

2-tert-butyl-5-[[1-(1-tert-butyl-6-ethyl-2-oxo-1,3-oxazocan-6-yl)-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-3-yl]amino]-2,3-dihydro-1,2-benzothiazole-1,1-dione;

tert-butyl 4-ethyl-4-(3-(4-(methylsulfonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-((4-(8-oxa-3-azabicyclo[3.2.1]octane-3-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-(3-(2-(4,4-difluoro-1-methylcyclohexyl)-1-oxoisoindolin-5-ylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(4-oxo-3-(4-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-(4-(1-methylpiperidin-4-yl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-{[2-(oxan-4-yl)-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl]amino}-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S)-tert-butyl 4-ethyl-4-(3-((3-methyl-4-(3-methylmorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-((3-methyl-4-(3-methylmorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tert-butyl-4-ethyl-4-(3-(3-methyl-4-(2-methylmorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S)-tert-butyl-4-ethyl-4-(3-(3-methyl-4-(2-methylmorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl-4-ethyl-4-(3-(3-methyl-4-(2-methylmorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-((3-methyl-4-(morpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2-(trifluoromethyl)azepan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S)-tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2-(trifluoromethyl)azepan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2-(trifluoromethyl)azepan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl-4-ethyl-4-(3-(3-methyl-4-(morpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-((3-fluoro-4-(morpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-((4-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-((3-methyl-4-(2-oxa-6-azaspiro[3.3]heptane-6-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-((4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate

tert-butyl 4-(3-((3-(cyanomethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-(3-(4-((3S,5R)-3,5-dimethylmorpholine-4-carbonyl)-3-methylphenylamino)-4-oxo-2,3,4,5-tetrahydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-(3-(4-((3R,5R)-3,5-dimethylmorpholine-4-carbonyl)-3-methylphenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-(3-(4-((3S,5S)-3,5-dimethylmorpholine-4-carbonyl)-3-methylphenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-(3-(4-(3,5-dimethylmorpholine-4-carbonyl)-3-methylphenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-(3-methyl-4-(thiomorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-(4-((1S,4S)-5-oxa-2-aza-bicyclo[2.2.1]heptane-2-carbonyl)-3-methylphenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(4-oxo-3-(4-(piperidin-4-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-((3-ethyl-4-(morpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-(3-(difluoromethyl)-4-(thiomorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-(3-(4-(4,4-difluoropiperidine-1-carbonyl)-3-methylphenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl-4-ethyl-4-(3-(3-methyl-4-(thiomorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tert-butyl-4-ethyl-4-(3-(3-methyl-4-(3-methylmorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-(3-ethyl-4-(thiomorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-((2-(1-methylpiperidin-4-yl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S)-tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2-(trifluoromethyl)piperidin-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2-(trifluoromethyl)piperidin-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2-(trifluoromethyl)piperidin-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-(3-methyl-4-(pyrrolidine-1-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S)-tert-butyl 4-ethyl-4-(4-oxo-3-(4-(2-(trifluoromethyl)pyrrolidin-2-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tert-butyl 4-ethyl-4-(4-oxo-3-(4-(2-(trifluoromethyl)pyrrolidin-2-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(4-oxo-3-(4-(2-(trifluoromethyl)pyrrolidin-2-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tert-butyl 4-(3-(4-(1-(tert-butylamino)-2,2,2-trifluoroethyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

(S)-tert-butyl 4-(3-(4-(1-(tert-butylamino)-2,2,2-trifluoroethyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-(3-(4-(1-(tert-butylamino)-2,2,2-trifluoroethyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-ethylpiperidine-1-carboxylate;

(S)-tert-butyl 4-ethyl-4-(3-(4-(2-methylpyrrolidin-1-ylsulfonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tert-butyl 4-ethyl-4-(3-(4-(2-methylpyrrolidin-1-ylsulfonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-(4-(2-methylpyrrolidin-1-ylsulfonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-(2-fluoropyridin-4-ylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S) tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2,2,2-trifluoro-1-methoxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R) tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2,2,2-trifluoro-1-methoxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2,2,2-trifluoro-1-methoxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R) tert-butyl 4-ethyl-4-(4-oxo-3-((4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S) tert-butyl 4-ethyl-4-(4-oxo-3-((4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(4-oxo-3-((4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S) tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R) tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(4-oxo-3-((4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

4-((1-(1-(tert-butoxycarbonyl)-4-ethylpiperidin-4-yl)-4-oxo-4,5-dihydro 1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-2-methylbenzoic acid;

tert-butyl-4-ethyl-4-(3-((3-methyl-4-(2-oxomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-[3-({4-[(2,2-dimethylmorpholin-4-yl)carbonyl]-3-methylphenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-{[3-methyl-4-(6-oxa-9-azaspiro[4.5]dec-9-ylcarbonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-{3-[(4-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl}-3-methylphenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-[3-({4-[(3,3-dimethylmorpholin-4-yl)carbonyl]-3-methylphenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-ethyl-4-[3-({3-methyl-4-[(1R,5S)-6-oxa-3-azabicyclo[3.1.1]hept-3-ylcarbonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-{3-[(4-{[(2S,6S)-2,6-dimethylmorpholin-4-yl]carbonyl}-3-methylphenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-ethyl-4-{3-[(3-methyl-4-{[(3R)-3-(1-methylethyl)morpholin-4-yl]carbonyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-{[3-methyl-4-(1,4-thiazepan-4-ylcarbonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-{[3-methyl-4-(1,4-oxazepan-4-ylcarbonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-[3-({3-methyl-4-[(1-oxidothiomorpholin-4-yl)carbonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-{3-[(3-methyl-4-{[(3R)-3-(1-methylethyl)morpholin-4-yl]carbonyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-{[3-methyl-4-(1,4-thiazepan-4-ylcarbonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-{[3-methyl-4-(1,4-oxazepan-4-ylcarbonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-[3-({3-methyl-4-[(1-oxidothiomorpholin-4-yl)carbonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-[3-({3-methyl-4-[(4-thiomorpholin-4-ylpiperidin-1-yl)carbonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-[3-({4-[(2,3-dimethylmorpholin-4-yl)carbonyl]-3-methylphenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]-4-ethylpiperidine-1-carboxylate;

tert-butyl 4-ethyl-4-{3-[(3-methyl-4-{[3-(2R-methylpropyl)morpholin-4-yl]carbonyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-{3-[(3-methyl-4-{[3-(2S-methylpropyl)morpholin-4-yl]carbonyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-{3-[(3-methyl-4-{[3-(methylpropyl)morpholin-4-yl]carbonyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-[3-({3-methyl-4-[(methyl-1,4-oxazepan-4-yl)carbonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-[3-({3-methyl-4-[(6R-methyl-1,4-oxazepan-4-yl)carbonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-[3-({3-methyl-4-[(6S-methyl-1,4-oxazepan-4-yl)carbonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-(3-{[3-methyl-4-(2-oxa-5-azabicyclo[4.1.0]hept-5-ylcarbonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-[3-({methyl-4-[(2-methyl-1,4-oxazepan-4-yl)carbonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-ethyl-4-[3-({3R-methyl-4-[(2-methyl-1,4-oxazepan-4-yl)carbonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate; and

tert-butyl 4-ethyl-4-[3-({3S-methyl-4-[(2-methyl-1,4-oxazepan-4-yl)carbonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate.

9. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable carrier.

10. A method of treating a condition in a mammal that can be ameliorated by the inhibition of Janus kinases JAK1 and JAK 2 which condition is selected from, arthritis, asthma and obstructive airways diseases, autoimmune diseases or disorders, and cancer comprising administering to the mammal in need of such treatment, a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.

11. A method according to claim 10 , wherein said condition is arthritis.

12. A method according to claim 11 , wherein said condition is selected from rheumatoid arthritis, juvenile arthritis, and psoriatic arthritis.

13. A method according to claim 12 , wherein said condition is asthma or obstructive airways diseases.

14. A method according to claim 13 , wherein said condition is selected from: chronic asthma, late asthma, airway hyper-responsiveness, bronchitis, bronchial asthma, allergic asthma, intrinsic asthma, extrinsic asthma, dust asthma, recurrent airway obstruction, and chronic obstruction pulmonary disease (COPD), and emphysema.

15. A method according to claim 10 , wherein said condition is autoimmune diseases or disorders.

16. A method of treating asthma in a mammal in need thereof, comprising administering a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.

17. A method of treating arthritis in a mammal in need thereof, comprising administering a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.