Methods and compositions for enhancing chemotherapy
View Patent ↗Embodiments of the invention are directed to methods and compositions using low dose sorafenib to enhance a cancer therapy.
1. A method of attenuating chemotherapy induced inflammation comprising administering a sub-cytotoxic dose of 0.001 to 1 mg/kg sorafenib in conjunction with a therapeutic dose of a chemotherapeutic alkylating agent.
2. The method of claim 1 , wherein the chemotherapy is administered to a patient having breast cancer or glioblastoma.
3. The method of claim 2 , wherein the breast cancer is a triple negative breast cancer.
4. A method of inhibiting growth of cancer cells comprising contacting the cancer cells with a low dose of 0.001 to 1 mg/kg sorafenib and an effective dose of a chemotherapeutic alkylating agent to which the cancer cells are sensitive.
5. The method of claim 4 , wherein the alkylating agent is cisplatin.
6. The method of claim 4 , wherein the low dose sorafenib is administered prior to the chemotherapeutic drug.
7. The method of claim 4 , wherein the low dose sorafenib is administered after administration of the chemotherapeutic drug.
8. The method of claim 4 , wherein the low dose sorafenib is administered within 15 minutes the chemotherapeutic drug.