IP Library › Granted Patent US 10,712,337
Granted Patent B2
US 10,712,337 · App. 15/521,190 · Granted Jul 14, 2020

Detecting gases and respiration by the conductivity of water within a porous substrate sensor

Inventors: Firat Güder (Watertown, MA); Bobak Mosadegh (New York, NY); Alar Ainla (Somerville, MA); George M. Whitesides (Newton, MA)
Assignee: President and Fellows of Harvard College
G01N33/497A61B5/0022A61B5/082A61B5/0816A61B5/0826G01N27/12G01N27/121G01N2033/4975
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Quick Facts
Patent No.
US 10,712,337
App. No.
15/521,190
Granted
Jul 14, 2020
Kind
B2
Abstract

A method of and system for detecting a gas or vapor includes providing a sensor comprising an electrode pair in electrical contact with a layer of porous material, the porous material layer having water adsorbed on its surface; contacting the sensor with a gas or vapor sample to be analysed; applying a voltage across the electrode pair of the sensor; and measuring a response, the response correlating to the presence of a target gas or vapor.

Claims (23)

1. A method of detecting respiration of a patient comprising:

providing a sensor comprising an electrode pair in electrical contact with a layer of hygroscopic porous cellulose paper material capable of adsorbing and desorbing water as a function of relative humidity;

positioning the sensor in the proximity of a mouth and/or nose of the patient; and

monitoring the change in water content of the sensor over time by application of a voltage across the electrode pair, such that a current is induced that is proportional to the ionic content of water in the hygroscopic porous cellulose material, and wherein the increase and decrease in water content is correlated to exhalation and inhalation, respectively.

2. The method of claim 1 , wherein the method detects a respiratory condition such as apnea, hypopnea and respiratory arrhythmia.

3. The method of claim 2 , wherein the respiratory condition is one or more of apnea, hypopnea and respiratory arrhythmia.

4. The method of claim 1 , wherein the response is an increase in current, indicating an increase in the adsorbed water in the sensor.

5. The method of claim 1 , wherein the response comprises one or more of current, electrical resistance, voltage, or conductance.

6. The method of claim 1 , wherein said response is wirelessly transmitted from the sensor to a remote location.

7. The method of claim 1 wherein a microcontroller is used to process the response of the sensor to generate data representative of said change of water content over time in an exhaled gas stream.

8. The method of claim 1 , wherein the increase and decrease in water content is used to generate data representative of breathing rate.

9. The method of claim 1 , wherein the increase and decrease in water content is used to generate data representative of breathing depth.

10. A respiration monitor, comprising:

a support capable of being positioned in the proximity of a mouth and/or nose of a patient; and

a sensor comprising an electrode pair in electrical contact with a layer of hygroscopic porous cellulose paper material capable of adsorbing and desorbing water as a function of relative humidity, said sensor attached to the support and located so as to be in the proximity of patient inhalation and exhalation, wherein upon application of a voltage across the electrode pair, current is induced that is proportional to the ionic content of water in the hygroscopic porous cellulose paper material.

11. The respiration monitor of claim 10 , further comprising an amplification agent in or on the hygroscopic porous cellulose paper material.

12. The respiration monitor of claim 10 , further comprising a damping agent in or on the hygroscopic porous cellulose paper material.

13. The respiration monitor of claim 10 , wherein the hygroscopic porous cellulose paper material comprises woven textiles, non-woven textiles, non-woven meshes, fabrics, or paper.

14. The respiration monitor of claim 10 , further comprising a voltage source configured to apply a voltage across the electrode pair.

15. The respiration monitor of claim 14 , wherein the voltage source is a battery.

16. The respiration monitor of claim 10 , further comprising a microcontroller for measuring a change in one or more of current, electrical resistance, voltage, or conductance.

17. The respiration monitor of claim 16 , further comprising a wireless transmitter for transmission of meter data to a remote location.

18. The respiration monitor of claim 10 , further comprising a sensitizing agent in or on the hygroscopic porous cellulose paper material.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 26, 2017
From: AINLA, ALAR; GUDER, FIRAT; MOSADEGH, BOBAK; WHITESIDES, GEORGE M.
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 042144/0437 →
Continuity (2)
Provisional Application 62067291 · Oct 22, 2014
Related Publication 20170356899A1 · Dec 14, 2017