Synergistic compositions for treating microbial infections
Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.
1. A topical composition comprising:
a compound (RNPA2000) of the following structure:
mupirocin, and
a pharmaceutically acceptable carrier suitable for topical administration,
wherein a weight ratio of the RNPA2000 and the mupirocin is from about 100:1 to about 1000:1.
2. The topical composition of claim 1 , wherein the weight ratio is from about 100:1 to about 400:1.
3. The topical composition of claim 1 , wherein the topical composition comprises an ointment, a gel, a cream, a powder, a spray, a liquid, a suspension, or a solution.
4. The topical composition of claim 3 , wherein the topical composition comprises an ointment.
5. A method of treating or preventing a microbial infection in a subject comprising administering to the subject an effective amount of a composition according to claim 1 .
6. The method of claim 5 , wherein the microbial infection is a bacterial infection.
7. The method of claim 6 , wherein the bacterial infection is a gram-positive bacterial infection or a gram-negative bacterial infection.
8. The method of claim 6 , wherein the bacterial infection is a Staphylococcus infection.
9. The method of claim 8 , wherein the Staphylococcus infection is a Staphylococcus aureus infection or a Staphylococcus pyogenes infection.
10. A method of decolonizing bacteria on a surface comprising contacting the surface with an effective amount of a composition comprising
a compound (RNPA2000) of the following structure:
and
mupirocin,
wherein a weight ratio of the RNPA2000 and the mupirocin is from about 100:1 to about 1000:1.