EZH2 inhibitors and uses thereof
The present disclosure provides compounds of any one of Formulae (I) and (II). The compounds described herein are inhibitors of histone methyltransferases (e.g., enhancer of zeste homolog 1 (EZH1) and enhancer of zeste homolog 2 (EZH2)) and are useful in treating and/or preventing a broad range of diseases (e.g., proliferative diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. Further provided in the present disclosure are methods of identifying EZH1 and/or EZH2 inhibitors.
1. A compound of the formula:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
3. A method of inhibiting the activity of an enhancer of zeste homolog 1 (EZH1) or an enhancer of zeste homolog 2 (EZH2) in a subject in need thereof, the method comprising administering to the subject an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
4. A method of inhibiting the activity of an enhancer of zeste homolog 1 (EZH1) or an enhancer of zeste homolog 2 (EZH2) in a cell, the method comprising contacting the cell with an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
5. A kit comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof and instructions for using the compound or a pharmaceutically acceptable salt thereof.
6. The method of claim 3 , wherein the subject is a human.
7. A method of treating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.
8. The method of claim 7 , wherein the cancer is lung cancer.
9. The method of claim 8 , wherein the lung cancer is non-small cell lung cancer.
10. The method of claim 7 , wherein the cancer is brain cancer.
11. The method of claim 7 , wherein the cancer is breast cancer.
12. The method of claim 7 , wherein the cancer is prostate cancer.
13. The method of claim 7 , wherein the cancer is lymphoma.
14. The method of claim 7 , wherein the cancer is leukemia.
15. A method of treating hyperplasia in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.
16. A method of treating a benign neoplasm in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.
17. The method of claim 7 , wherein the subject is a human.
18. The method of claim 8 , wherein the subject is a human.
19. The method of claim 9 , wherein the subject is a human.
20. The method of claim 10 , wherein the subject is a human.
21. The method of claim 11 , wherein the subject is a human.
22. The method of claim 12 , wherein the subject is a human.
23. The method of claim 13 , wherein the subject is a human.
24. The method of claim 14 , wherein the subject is a human.