Sodium channel blockers

1. A compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof:

In the above Formula,

X 1 is C—R a or N, X 2 is C—R b or N, X 3 is C—R c or N, X 4 is C—R d or N,

R a , R b , R c and R d are each independently hydrogen, C 1-4 alkyl, C 3-6 cycloalkyl, C 1-4 alkoxy, C 6-10 aryl, 5-membered or 6-membered heteroaryl, halogen or cyano,

X 5 is CH, or N, X 6 is C—R e or N, X 7 is CH or N, X 8 is C—R f or N,

R e is hydrogen; C 1-4 alkyl; C 2-4 alkynyl which is unsubstituted or substituted with C 1-4 hydorxyalkyl; C 3-6 cycloalkyl; —COO—(C 1-4 alkyl); —NHCO—(C 1-4 alkyl); —CH═CH-(pyridinyl); amino; carboxy; cyano; halogen; morpholino; 5-membered or 6-membered heteroaryl which is unsubstituted or substituted with a substituent selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, amino and halogen; phenyl which is unsubstituted or substituted with one to three substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, halogen, amino, cyano and nitro; pyridin-2-onyl which is unsubstituted or substituted with C 1-4 alkyl; styryl which is unsubstituted or substituted with a substituent selected from the group consisting of C 1-4 halolkyl and halogen; or tetrahydropyridinyl which is unsubstituted or substituted with —COO—(C 1-4 alkyl),

R f is hydrogen, benzyloxy or phenyl,

X 9 is C—R g or N,

R g is hydrogen; C 1-4 alkyl; C 1-4 alkoxy which is unsubstituted or substituted with a substituent selected from the group consisting of C 3-6 cycloalkyl, phenyl, phenyl substituted with halogen, and naphthyl; C 1-4 haloalkyl; C 3-6 cycloalkyl; amino; halogen; hydroxy; nitro; phenylamino; benzyloxy which is unsubstituted or substituted with halogen; phenyl which is unsubstituted or substituted with one to three substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, cyano, amino, nitro and halogen; 5-membered or 6-membered heteroaryl which is unsubstituted or substituted with a substituent independently selected from the group consisting of C 1-4 alkyl and halogen; or pyridinyloxy which is unsubstituted or substituted with halogen,

X 10 is C—R h or N,

R h is hydrogen, halogen or benzyloxy,

R is —CO—N(R i )—SO 2 —R ii , —SO 2 —NH—R iii , —CONH—R iv , dihydrotriazolonyl, or tetrazolyl,

R i is hydrogen; C 1-4 alkyl; naphthylmethyl; or benzyl which is unsubstituted or substituted with halogen;

R ii is C 1-4 alkyl or N(C 1-4 alkyl) 2 ,

R iii is 5-membered or 6-membered heteroaryl which is unsubstituted or substituted with a substituent selected from the group consisting of C 1-4 alkyl and halogen; and

R iv is —CO—(C 1-4 alkyl); —NHCO—NH 2 ; or thiazolyl which is unsubstituted or substituted with a substituent selected from the group consisting of C 1-4 alkyl and —COO—(C 1-4 alkyl).

2. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein X 1 is C—R a or N, X 2 is CH, X 3 is C—R c , and X 4 is CH.

3. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein R a , R b , R c , and R d are each independently hydrogen, fluoro, chloro or cyano.

4. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein X 1 is C—Cl, X 2 is CH, X 3 is C—F, and X 4 is CH.

5. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein the 5-membered or 6-membered heteroaryl of R e is pyrazolyl unsubstituted or substituted with C 1-4 alkyl; pyridinyl unsubstituted or substituted with a substituent selected from the group consisting of C 1-4 alkoxy and halogen; or thiazolyl unsubstituted or substituted with C 1-4 alkyl.

6. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein R e is hydrogen; methyl; ethynyl substituted with hydroxyisopropyl; cyclopropyl; —COO-(methyl); —NHCO-(methyl); —CH═CH-(pyridinyl); amino; carboxy; cyano; bromo; chloro; morpholino; pyrazolyl unsubstituted or substituted with methyl; pyridinyl unsubstituted or substituted with a substituent selected from the group consisting of methoxy, fluoro and chloro; thiazolyl unsubstituted or substituted with methyl; phenyl unsubstituted or substituted with one to three substituents independently selected from the group consisting of methyl, methoxy, trifluoromethyl, trifluoromethoxy, fluoro, chloro, amino, cyano and nitro; pyridin-2-onyl unsubstituted or substituted with methyl; styryl unsubstituted or substituted with a substituent selected from the group consisting of trifluoromethyl, fluoro and chloro; or tetrahydropyridinyl unsubstituted or substituted with —COO-(tert-butyl).

7. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein R i is hydrogen; methyl; naphthylmethyl; or benzyl substituted with fluoro, and R ii is methyl or dimethylamino.

8. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein R iv —CO-(methyl); —NHCO—NH 2 ; or thiazolyl unsubstituted or substituted with one or substituents selected from the group consisting of methyl and —COO-(ethyl).

9. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein X 9 is C—R g and X 10 is C—R h .

10. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein

X 9 is C—R g , and

R g is hydrogen; isobutyl; methoxy, ethoxy or isobutoxy, which is unsubstituted or substituted with a substituent selected from the group consisting of cyclohexyl, phenyl, phenyl substituted with fluoro, and naphthyl; trifluoromethyl; cyclopropyl; amino; fluoro; chloro; bromo; hydroxy; nitro; phenylamino; benzyloxy unsubstituted or substituted with fluoro; phenyl unsubstituted or substituted with one or two substituents independently selected from the group consisting of methyl, methoxy, trifluoromethyl, cyano, fluoro and chloro; pyrazolyl substituted with methyl; pyridinyl unsubstituted or substituted with one or two substituents selected from the group consisting of fluoro and chloro; pyridinyloxy unsubstituted or substituted with fluoro; or pyrimidinyl.

11. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein X 10 is C—R h and R h is hydrogen, chloro or benzyloxy.

12. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein

X 5 is N, X 6 is C—R e , X 7 is CH, and X 8 is C—R f , or

X 5 is CH, X 6 is C—R e , X 7 is N, and X 8 is C—R f , or

X 5 is CH, X 6 is C—R e , X 7 is CH, and X 8 is C—R f , or

X 5 is N, X 6 is C—R e , X 7 is N, X 8 is C—R f , or

X 5 is N, X 6 is C—R e , X 7 is CH, and X 8 is N.

13. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein

X 1 is C—R a or N, X 2 is C—R b , X 3 is C—R c , X 4 is C—R d ,

X 5 is N, X 6 is C—R e , X 7 is CH, X 8 is C—R f ,

R e is hydrogen; C 1-4 alkyl; C 2-4 alkynyl unsubstituted or substituted with C 1-4 hydroxyalkyl; C 3-6 cycloalkyl; —COO—(C 1-4 alkyl); —NHCO—(C 1-4 alkyl); —CH═CH-(pyridinyl); amino; cyano; halogen; morpholino; 5-membered or 6-membered heteroaryl unsubstituted or substituted with a substituent selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy and halogen; phenyl unsubstituted or substituted with one to three substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, halogen, amino, cyano and nitro; pyridin-2-onyl unsubstituted or substituted with C 1-4 alkyl; styryl unsubstituted or substituted with a substituent selected from the group consisting of C 1-4 haloalkyl and halogen; or tetrahydro-pyridinyl unsubstituted or substituted with —COO—(C 1-4 alkyl),

X 9 is C—R g ,

X 10 is C—R h , and

R h is hydrogen or halogen.

14. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein

X 1 is C—R a , X 2 is C—R b , X 3 is C—R c , and X 4 is C—R d ,

R a , R b , R c and R d are each independently hydrogen or halogen,

X 5 is CH, X 6 is C—R e , X 7 is N, and X 8 is C—R f ,

R e is halogen; or phenyl unsubstituted or substituted with one to three substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, halogen, amino, cyano and nitro,

R f is hydrogen,

X 9 is C—R g ,

R g is hydrogen, halogen, or phenyl unsubstituted or substituted with a substituent selected from the group consisting of C 1-4 alkoxy, C 1-4 haloalkyl, cyano and halogen,

X 10 is C—R h ,

R h is hydrogen,

R is —CO—N(R i )—SO 2 —R ii ,

R i is hydrogen, and

R ii is C 1-4 alkyl.

15. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein

X 1 is C—R a or N, X 2 is C—R b , X 3 is C—R c , and X 4 is C—R d ,

R a , R b , R c and R d are each independently hydrogen or halogen,

X 5 is CH, X 6 is C—R e , X 7 is CH, and X 8 is C—R f ,

R e is carboxy; halogen; 5-membered or 6-membered heteroaryl unsubstituted or substituted with a substituent selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy and halogen; or phenyl unsubstituted or substituted with one to three substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, halogen, amino, cyano and nitro,

R f is hydrogen or benzyloxy,

X 9 is C—R g ,

R g is hydrogen; C 1-4 alkoxy unsubstituted or substituted with a substituent selected from the group consisting of C 3-6 cycloalkyl, phenyl, phenyl substituted with halogen, and naphthyl; halogen; hydroxy; or benzyloxy unsubstituted or substituted with halogen,

X 10 is C—R h ,

R is —CO—N(R i )—SO 2 —R ii ,

R i is hydrogen, and

R ii is C 1-4 alkyl.

16. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein

X 1 is C—R a , X 2 is C—R b , X 3 is C—R c , and X 4 is C—R d ,

R a , R b , R c and R d are each independently hydrogen or halogen,

X 5 is N, X 6 is C—R e , X 7 is N, X 8 is C—R f ,

R e is halogen,

R f is hydrogen,

X 9 is C—R g ,

R g is halogen,

X 10 is C—R h ,

R h is hydrogen,

R is —CO—N(R i )—SO 2 —R ii ,

R i is hydrogen, and

R ii is C 1-4 alkyl.

17. The compound or a pharmaceutically acceptable salt thereof according to claim 1 wherein

X, is C—R a , X 2 is C—R b , X 3 is C—R c , and X 4 is C—R d ,

R a , R b , R c and R d are each independently hydrogen or halogen,

X 5 is N, X 6 is C—R e , X 7 is CH, X 8 is N,

R e is hydrogen or halogen;

X 9 is C—R g ,

R g is halogen,

X 10 is C—R h ,

R h is hydrogen,

R is —CO—N(R i )—SO 2 —R ii ,

R i is hydrogen, and

R ii is C 1-4 alkyl.

18. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of

1) 5-chloro-4-(5-chloro-3-methyl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

2) 5-chloro-4-(5-chloro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

3) 5-chloro-4-(3,5-dichloro-1H-pyrazolo[3,4-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

4) 4-(3,5-dichloro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

5) 4-(3-amino-5-chloro-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

6) 4-(3-acetamido-5-chloro-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

7) 5-chloro-4-(3,5-dichloro-1H-indazol-1-yl)-N—(N,N-dimethylsulfamoyl)-2-fluorobenzamide,

8) 3-chloro-4-(3,5-dichloro-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

9) 5-chloro-4-(3,5-dichloro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

10) 5-chloro-4-(5-chloro-1H-pyrazolo[3,4-c]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

11) 5-chloro-4-(3,5-dichloro-1H-pyrazolo[3,4-c]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

12) 4-(3-chloro-5-hydroxy-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

13) 4-(5-amino-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

14) 5-chloro-2-fluoro-4-(3-methyl-5-nitro-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

15) 5-chloro-4-(4-chloro-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

16) 5-chloro-4-(3-chloro-5-hydroxy-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

17) 5-chloro-4-(3-chloro-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

18) 5-chloro-4-(3-chloro-5-(trifluoromethyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

19) 4-(3-bromo-5-chloro-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

20) 5-chloro-4-(3,5-dichloro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

21) 4-(5-bromo-3-chloro-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

22) 4-(5-bromo-3-cyano-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

23) 5-chloro-4-(3-chloro-5-nitro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

24) 5-chloro-4-(3-chloro-5-cyclopropyl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

25) 5-chloro-4-(5-chloro-3-cyclopropyl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

26) 5-chloro-4-(5-cyclopropyl-3-phenyl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

27) 5-chloro-4-(3-chloro-5-(phenylamino)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

28) 4-(5-(benzyloxy)-3-chloro-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

29) 4-(5-(benzyloxy)-4-chloro-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

30) 4-(5-(benzyloxy)-3-methyl-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

31) 5-chloro-4-(3,4-dichloro-5-((4-fluorobenzyl)oxy)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

32) 5-chloro-4-(3,4-dichloro-5-((2-fluorobenzyl)oxy)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

33) 5-chloro-4-(3-chloro-5-(1-phenylethoxy)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

34) 5-chloro-4-(3-chloro-5-(cyclohexylmethoxy)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

35) 5-chloro-4-(3-chloro-5-(naphthalen-2-ylmethoxy)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

36) 5-chloro-4-(3-chloro-5-((4-fluorobenzyl)oxy)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

37) 5-chloro-4-(3-chloro-5-((2-fluorobenzyl)oxy)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

38) 5-chloro-4-(3-chloro-5-((3-fluorobenzyl)oxy)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

39) 5-chloro-4-(3-chloro-5-(1-(4-fluorophenyl)ethoxy)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

40) 5-chloro-4-(3-chloro-5-phenethoxy-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

41) 5-chloro-2-fluoro-4-(5-isobutoxy-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

42) 5-chloro-4-(3-chloro-5-isobutoxy-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

43) 4-(5-(benzyloxy)-3-chloro-1H-indazol-1-yl)-5-chloro-N—(N,N-dimethylsulfamoyl)-2-fluorobenzamide,

44) 4-(5-(benzyloxy)-3-chloro-1H-indazol-1-yl)-3-chloro-N-(methylsulfonyl)benzamide,

45) 4-(6-(benzyloxy)-3-chloro-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

46) methyl 6-(benzyloxy)-1-(2-chloro-5-fluoro-4-((methylsulfonyl)carbamoyl)phenyl)-1H-indazole-3-carboxylate,

47) 5-chloro-4-(3-chloro-5-((6-fluoropyridin-3-yl)oxy)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

48) 5-chloro-4-(5-chloro-3-phenyl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

49) 5-chloro-4-(5-chloro-3-(pyridin-4-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

50) 5-chloro-4-(5-chloro-3-(pyridin-3-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

51) 5-chloro-4-(5-chloro-3-(5-chloropyridin-3-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

52) 5-chloro-4-(5-chloro-3-(m-tolyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

53) 5-chloro-4-(5-chloro-3-(2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

54) 5-chloro-4-(5-chloro-3-(3-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

55) 5-chloro-4-(5-chloro-3-(4-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

56) 5-chloro-4-(5-chloro-3-(2,4-difluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

57) 5-chloro-4-(5-chloro-3-(2-methoxypyridin-3-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

58) 5-chloro-4-(5-chloro-3-(2-methoxyphenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

59) 5-chloro-4-(5-chloro-3-(4-methoxyphenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

60) 5-chloro-4-(5-chloro-3-(2-cyanophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

61) 5-chloro-4-(5-chloro-3-(3-cyanophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

62) 5-chloro-4-(5-chloro-3-(4-cyanophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

63) 5-chloro-4-(5-chloro-3-(2-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

64) 5-chloro-4-(5-chloro-3-(3-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

65) 5-chloro-4-(5-chloro-3-(4-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

66) 5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

67) 5-chloro-4-(5-chloro-3-(4-chlorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

68) 5-chloro-4-(5-chloro-3-(2-fluoropyridin-4-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

69) 5-chloro-4-(5-chloro-3-(5-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

70) 5-chloro-4-(5-chloro-3-(3-cyano-4-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

71) 5-chloro-4-(5-chloro-3-(2-chlorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

72) 5-chloro-4-(5-chloro-3-(3-chlorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

73) 5-chloro-4-(5-chloro-3-(3-chloro-5-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

74) 5-chloro-4-(5-chloro-3-(2-chloro-4-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

75) 5-chloro-4-(5-chloro-3-(3,4-difluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

76) 5-chloro-4-(5-chloro-3-(2,5-difluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

77) 5-chloro-4-(5-chloro-3-(3,4,5-trifluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

78) 5-chloro-4-(5-chloro-3-(2-chloro-6-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

79) 5-chloro-4-(5-chloro-3-(3-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

80) 5-chloro-4-(5-chloro-3-(4-chloro-3-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

81) 5-chloro-4-(5-chloro-3-(4-nitrophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

82) 4-(3-(4-aminophenyl)-5-chloro-1H-indazol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

83) 5-chloro-4-(5-chloro-3-(4-(trifluoromethoxy)phenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

84) 5-chloro-2-fluoro-4-(5-isobutyl-3-phenyl-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

85) 5-chloro-4-(3-(4-chlorophenyl)-5-cyclopropyl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

86) 5-chloro-4-(5-chloro-3-morpholino-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

87) 5-chloro-4-(5-chloro-3-(1-methyl-1H-pyrazol-5-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

88) 5-chloro-4-(5-chloro-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

89) 5-chloro-4-(5-chloro-3-(1H-pyrazol-4-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

90) 5-chloro-4-(5-chloro-3-(1H-pyrazol-3-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

91) 5-chloro-4-(5-chloro-3-(2-methylthiazol-5-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

92) 4-(5-chloro-3-(2-methoxyphenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

93) 4-(5-chloro-3-(4-methoxyphenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

94) 4-(5-chloro-3-(2-cyanophenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

95) 4-(5-chloro-3-(3-cyanophenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

96) 4-(5-chloro-3-(4-cyanophenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

97) 4-(5-chloro-3-(2-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

98) 4-(5-chloro-3-(3-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

99) 4-(5-chloro-3-(4-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

100) 4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

101) 4-(5-chloro-3-(4-fluorophenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

102) 4-(5-chloro-3-(2-fluorophenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

103) 4-(5-chloro-3-(3-fluorophenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

104) 4-(5-chloro-3-(5-chloropyridin-3-yl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

105) 4-(5-chloro-3-(2,4-difluorophenyl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

106) 4-(5-chloro-3-(2-methoxypyridin-3-yl)-1H-indazol-1-yl)-3-cyano-N-(methylsulfonyl)benzamide,

107) 2-chloro-4-(5-chloro-3-(2-methoxyphenyl)-1H-indazol-1-yl)-5-fluoro-N-(methylsulfonyl)benzamide,

108) 2-chloro-4-(5-chloro-3-(4-methoxyphenyl)-1H-indazol-1-yl)-5-fluoro-N-(methylsulfonyl)benzamide,

109) 2-chloro-4-(5-chloro-3-(3-cyanophenyl)-1H-indazol-1-yl)-5-fluoro-N-(methylsulfonyl)benzamide,

110) 2-chloro-4-(5-chloro-3-(3-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-5-fluoro-N-(methylsulfonyl)benzamide,

111) 2-chloro-4-(5-chloro-3-(4-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-5-fluoro-N-(methylsulfonyl)benzamide,

112) 2-chloro-4-(5-chloro-3-(4-fluorophenyl)-1H-indazol-1-yl)-5-fluoro-N-(methylsulfonyl)benzamide,

113) 2-chloro-4-(5-chloro-3-(2-fluorophenyl)-1H-indazol-1-yl)-5-fluoro-N-(methylsulfonyl)benzamide,

114) 2-chloro-4-(5-chloro-3-(3-fluorophenyl)-1H-indazol-1-yl)-5-fluoro-N-(methylsulfonyl)benzamide,

115) 2-chloro-4-(5-chloro-3-(2,4-difluorophenyl)-1H-indazol-1-yl)-5-fluoro-N-(methylsulfonyl)benzamide,

116) 2-chloro-4-(5-chloro-3-(2-methoxypyridin-3-yl)-1H-indazol-1-yl)-5-fluoro-N-(methylsulfonyl)benzamide,

117) 4-(5-chloro-3-(2-methoxyphenyl)-1H-indazol-1-yl)-3-fluoro-N-(methylsulfonyl)benzamide,

118) 4-(5-chloro-3-(4-methoxyphenyl)-1H-indazol-1-yl)-3-fluoro-N-(methylsulfonyl)benzamide,

119) 4-(5-chloro-3-(3-cyanophenyl)-1H-indazol-1-yl)-3-fluoro-N-(methylsulfonyl)benzamide,

120) 4-(5-chloro-3-(4-cyanophenyl)-1H-indazol-1-yl)-3-fluoro-N-(methylsulfonyl)benzamide,

121) 4-(5-chloro-3-(3-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-3-fluoro-N-(methylsulfonyl)benzamide,

122) 4-(5-chloro-3-(4-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-3-fluoro-N-(methylsulfonyl)benzamide,

123) 4-(5-chloro-3-(4-fluorophenyl)-1H-indazol-1-yl)-3-fluoro-N-(methylsulfonyl)benzamide,

124) 4-(5-chloro-3-(2-fluorophenyl)-1H-indazol-1-yl)-3-fluoro-N-(methylsulfonyl)benzamide,

125) 4-(5-chloro-3-(3-fluorophenyl)-1H-indazol-1-yl)-3-fluoro-N-(methylsulfonyl)benzamide,

126) 4-(5-chloro-3-(4-chlorophenyl)-1H-indazol-1-yl)-3-fluoro-N-(methylsulfonyl)benzamide,

127) 4-(5-chloro-3-phenyl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

128) 6-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)nicotinamide,

129) 5-chloro-4-(5-chloro-3-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

130) 5-chloro-4-(5-chloro-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

131) tert-butyl 4-(5-chloro-1-(2-chloro-5-fluoro-4-((methylsulfonyl)carbamoyl)phenyl)-1H-indazol-3-yl)-3,6-dihydropyridine-1(2H)-carboxylate,

132) 5-chloro-4-(5-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

133) (E)-5-chloro-4-(5-chloro-3-styryl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

134) (E)-5-chloro-4-(5-chloro-3-(2-(pyridin-2H)vinyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

135) (E)-5-chloro-4-(5-chloro-3-(2-fluorostyryl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

136) (E)-5-chloro-4-(5-chloro-3-(2-chlorostyryl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

137) (E)-5-chloro-4-(5-chloro-3-(4-(trifluoromethyl)styryl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

138) 5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-N—(N,N-dimethylsulfamoyl)-2-fluorobenzamide,

139) 5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-methyl-N-(methylsulfonyl)benzamide,

140) 5-chloro-4-(3-chloro-5-hydroxy-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)-N-(naphthalen-2-ylmethyl)benzamide,

141) 5-chloro-4-(3-chloro-5-hydroxy-1H-indazol-1-yl)-2-fluoro-N-(4-fluorobenzyl)-N-(methylsulfonyl)benzamide,

142) 5-chloro-4-(3-(4-chloro-2-fluorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

143) 5-chloro-2-fluoro-4-(5-fluoro-3-(2-fluorophenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

144) 5-chloro-4-(3-(2-chlorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

145) 5-chloro-2-fluoro-4-(5-fluoro-3-(2-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

146) 5-chloro-2-fluoro-4-(5-fluoro-3-(2-methoxyphenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

147) 5-chloro-2-fluoro-4-(5-fluoro-3-(o-tolyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

148) 5-chloro-2-fluoro-4-(5-fluoro-3-(3-fluorophenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

149) 5-chloro-4-(3-(3-chlorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

150) 5-chloro-2-fluoro-4-(5-fluoro-3-(3-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

151) 5-chloro-2-fluoro-4-(5-fluoro-3-(3-methoxyphenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

152) 5-chloro-2-fluoro-4-(5-fluoro-3-(m-tolyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

153) 5-chloro-2-fluoro-4-(5-fluoro-3-(4-fluorophenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

154) 5-chloro-4-(3-(4-chlorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

155) 5-chloro-2-fluoro-4-(5-fluoro-3-(4-methoxyphenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

156) 5-chloro-2-fluoro-4-(5-fluoro-3-(p-tolyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

157) 5-chloro-4-(3-(3-chloro-5-fluorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

158) 5-chloro-4-(3-(2-chloro-4-fluorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

159) 5-chloro-4-(3-(2,4-difluorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

160) 5-chloro-4-(3-(2,5-difluorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

161) 5-chloro-4-(3-(3,4-difluorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

162) 5-chloro-4-(3-(2-chloro-6-fluorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

163) 5-chloro-4-(3-(3-chloro-2-fluorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

164) 5-chloro-4-(3-(4-chloro-3-fluorophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

165) 5-chloro-2-fluoro-4-(5-fluoro-3-(pyridin-3-yl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

166) 5-chloro-4-(3-(3-cyanophenyl)-5-fluoro-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

167) 3-cyano-4-(5-fluoro-3-(pyridin-3-yl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

168) 3-cyano-4-(3-(3-cyanophenyl)-5-fluoro-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

169) 5-chloro-4-(3-(4-chloro-2-fluorophenyl)-5-methoxy-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

170) 5-chloro-4-(3-(3-chlorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

171) 5-chloro-2-fluoro-4-(3-(3-fluorophenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

172) 5-chloro-2-fluoro-N-(methylsulfonyl)-4-(3-(3-(trifluoromethyl)phenyl)-1H-indazol-1-yl)benzamide,

173) 5-chloro-2-fluoro-N-(methylsulfonyl)-4-(3-(o-tolyl)-1H-indazol-1-yl)benzamide,

174) 5-chloro-2-fluoro-4-(3-(2-methoxyphenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

175) 5-chloro-4-(3-(2-chloro-4-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

176) 5-chloro-4-(3-(2,4-difluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

177) 5-chloro-2-fluoro-4-(3-(4-fluoropyridin-3-yl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

178) 5-chloro-2-fluoro-N-(methylsulfonyl)-4-(3-(4-(trifluoromethyl)phenyl)-1H-indazol-1-yl)benzamide,

179) 5-chloro-2-fluoro-4-(3-(4-fluorophenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

180) 5-chloro-2-fluoro-N-(methylsulfonyl)-4-(3-(pyridin-3-yl)-1H-indazol-1-yl)benzamide,

181) 5-chloro-4-(3-(3-cyanophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

182) 3-cyano-N-(methylsulfonyl)-4-(3-(pyridin-3-yl)-1H-indazol-1-yl)benzamide,

183) 3-cyano-4-(3-(3-cyanophenyl)-1H-indazol-1-yl)-N-(methylsulfonyl)benzamide,

184) 5-chloro-4-(3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

185) 5-chloro-4-(5-chloro-3-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

186) 5-chloro-4-(5-chloro-3-(2,4-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

187) 5-chloro-4-(5-chloro-3-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

188) 5-chloro-4-(5-chloro-3-(4-(trifluoromethyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

189) 5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

190) 5-chloro-4-(5-chloro-3-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

191) 5-chloro-4-(5-chloro-3-(2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

192) 5-chloro-4-(5-chloro-3-(3-(trifluoromethyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

193) 5-chloro-4-(5-chloro-3-(2-(trifluoromethyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

194) 5-chloro-4-(5-chloro-3-(3-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

195) 5-chloro-4-(5-chloro-3-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

196) 5-chloro-4-(5-chloro-3-(4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

197) 5-chloro-4-(5-chloro-3-(2-chloro-4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

198) 5-chloro-4-(5-chloro-3-(2-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

199) 5-chloro-4-(5-chloro-3-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

200) 5-chloro-4-(5-chloro-3-(4-fluoro-2-methylphenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

201) 5-chloro-4-(3-(4-chloro-2-fluorophenyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

202) 5-chloro-4-(3-(2-chloro-4-fluorophenyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

203) 5-chloro-4-(3-(2,4-difluorophenyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

204) 5-chloro-4-(3-(4-chlorophenyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

205) 5-chloro-2-fluoro-4-(5-fluoro-3-(4-(trifluoromethyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-N-(methylsulfonyl)benzamide,

206) 5-chloro-2-fluoro-4-(5-fluoro-3-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-N-(methylsulfonyl)benzamide,

207) 5-chloro-4-(3-(2-chlorophenyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

208) 5-chloro-4-(3-(3-chlorophenyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

209) 5-chloro-4-(3-(2,4-dichlorophenyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

210) 5-chloro-4-(3-(4-chloro-3-fluorophenyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

211) 5-chloro-4-(3-(3-chloro-2-fluorophenyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

212) 5-chloro-2-fluoro-4-(5-fluoro-3-(4-fluoro-2-methylphenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-N-(methylsulfonyl)benzamide,

213) 5-chloro-2-fluoro-4-(3-(2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-A-N-(methylsulfonyl)benzamide,

214) 5-chloro-2-fluoro-4-(3-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-A-N-(methylsulfonyl)benzamide,

215) 5-chloro-2-fluoro-N-(methylsulfonyl)-4-(3-(m-tolyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)benzamide,

216) 5-chloro-2-fluoro-N-(methylsulfonyl)-4-(3-(2-(trifluoromethyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)benzamide,

217) 5-chloro-2-fluoro-N-(methylsulfonyl)-4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)benzamide,

218) 5-chloro-2-fluoro-N-(methylsulfonyl)-4-(3-(4-(trifluoromethyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)benzamide,

219) 5-chloro-4-(3-(5-chloro-2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

220) 5-chloro-4-(3-(3-chloro-5-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

221) 5-chloro-4-(3-(3-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

222) 5-chloro-4-(3-(3-chloro-2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

223) 5-chloro-4-(3-(4-chloro-3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

224) 5-chloro-4-(3-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

225) 5-chloro-4-(3-(2-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

226) 5-chloro-2-fluoro-4-(3-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-N-(methylsulfonyl)benzamide,

227) 5-chloro-4-(3-(4-chloro-2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

228) 5-chloro-4-(3-(2-chloro-4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

229) 5-chloro-4-(3-(2,4-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

230) 5-chloro-4-(3-chloro-5-phenyl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

231) 5-chloro-4-(3-chloro-5-(pyridin-3-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

232) 5-chloro-4-(3-chloro-5-(pyridin-4-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

233) 5-chloro-4-(3-chloro-5-(m-tolyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

234) 5-chloro-4-(3-chloro-5-(2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

235) 5-chloro-4-(3-chloro-5-(3-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

236) 5-chloro-4-(3-chloro-5-(4-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

237) 5-chloro-4-(3-chloro-5-(2-cyanophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

238) 5-chloro-4-(3-chloro-5-(5-cyano-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

239) 5-chloro-4-(3-chloro-5-(3-cyano-4-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

240) 5-chloro-4-(3-chloro-5-(4-cyanophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

241) 5-chloro-4-(3-chloro-5-(pyrimidin-5-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

242) 5-chloro-4-(3-chloro-5-(5-chloropyridin-3-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

243) 5-chloro-4-(3-chloro-5-(2,4-difluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

244) 5-chloro-4-(3-chloro-5-(2-fluoropyridin-3-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

245) 5-chloro-4-(3-chloro-5-(6-fluoropyridin-3-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

246) 5-chloro-4-(3-chloro-5-(2,6-difluoropyridin-3-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

247) 5-chloro-4-(3-chloro-5-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

248) 5-chloro-4-(3-chloro-5-(4-methoxyphenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

249) 5-chloro-4-(3-chloro-5-(3-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

250) 5-chloro-4-(3-chloro-5-(2-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

251) 5-chloro-4-(3-chloro-5-(4-(trifluoromethyl)phenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

252) 5-chloro-4-(3-chloro-5-(2-chlorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

253) 5-chloro-4-(3-chloro-5-(4-chloro-2-methylphenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

254) 5-chloro-4-(3-chloro-5-(5-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

255) 5-chloro-4-(3-chloro-5-(4-chlorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

256) 5-chloro-4-(3-chloro-5-(1-methyl-1H-pyrazol-5-yl)-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

257) 5-chloro-4-(3-chloro-5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

258) 5-chloro-4-(3-chloro-5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

259) 5-chloro-4-(3-chloro-5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

260) 5-chloro-4-(3-chloro-5-(4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

261) 5-chloro-4-(3-chloro-5-(4-(trifluoromethyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

262) 5-chloro-4-(3-chloro-5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

263) 5-chloro-4-(3-chloro-6-phenyl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

264) 5-chloro-4-(3,5-diphenyl-1H-indazol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

265) 5-chloro-1-(2-chloro-5-fluoro-4-((methylsulfonyl)carbamoyl)phenyl)-1H-indole-3-carboxylic acid,

266) 5-chloro-4-(3,5-dichloro-1H-indol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

267) 5-chloro-4-(3,4-dichloro-5-hydroxy-1H-indol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

268) 5-chloro-4-(3-chloro-5-methoxy-1H-indol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

269) 4-(5-(benzyloxy)-3-chloro-1H-indol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

270) 4-(4-(benzyloxy)-3-chloro-1H-indol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

271) 4-(6-(benzyloxy)-3-chloro-1H-indol-1-yl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide,

272) 5-chloro-4-(5-chloro-3-(4-chlorophenyl)-1H-indol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

273) 5-chloro-4-(5-chloro-3-(6-chloropyridin-3-yl)-1H-indol-1-yl)-2-fluoro-N-(methylsulfonyl)benzamide,

274) 6-(5-chloro-3-(4-chlorophenyl)-1H-indol-1-yl)-N-(methylsulfonyl)nicotinamide,

275) 6-(5-chloro-3-(4-fluorophenyl)-1H-indol-1-yl)-N-(methylsulfonyl)nicotinamide,

276) 5-chloro-4-(3-chloro-5-phenyl-1H-indazol-1-yl)-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide,

277) 5-chloro-4-(5-chloro-3-methyl-1H-indazol-1-yl)-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide,

278) 4-(3-chloro-5-(trifluoromethyl)-1H-indazol-1-yl)-3-cyano-N-(thiazol-4-yl)benzenesulfonamide,

279) 4-(3-chloro-5-(trifluoromethyl)-1H-indazol-1-yl)-2,5-difluoro-N-(thiazol-4-yl)benzenesulfonamide,

280) 5-chloro-4-(3-chloro-5-(trifluoromethyl)-1H-indazol-1-yl)-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide,

281) 4-(3-chloro-5-(trifluoromethyl)-1H-indazol-1-yl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide,

282) 5-chloro-4-(5-chloro-3-(1-methyl-1H-pyrazol-5-yl)-1H-indazol-1-yl)-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide,

283) 5-chloro-4-(5-chloro-3-(1-methyl-1H-pyrazol-5-yl)-1H-indazol-1-yl)-2-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide,

284) 5-chloro-4-(5-chloro-3-(1H-pyrazol-4-yl)-1H-indazol-1-yl)-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide,

285) 5-chloro-2-fluoro-4-(5-(1-methyl-1H-pyrazol-5-yl)-1H-indazol-1-yl)-N-(thiazol-4-yl)benzenesulfonamide,

286) 5-chloro-4-(3-chloro-5-(1-methyl-1H-pyrazol-5-yl)-1H-indazol-1-yl)-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide,

287) 5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide,

288) 5-chloro-3-(4-chloro-2-fluorophenyl)-1-(2-chloro-5-fluoro-4-(1H-tetrazol-5-yl)phenyl)-1H-indazole,

289) 2-(5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluorobenzoyl)hydrazine-1-carboxamide,

290) 5-(5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one,

291) 5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluorobenzamide,

292) N-acetyl-5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluorobenzamide,

293) 5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(thiazol-2-yl)benzamide,

294) 5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluoro-N-(5-methylthiazol-2-yl)benzamide, and

295) ethyl 2-(5-chloro-4-(5-chloro-3-(4-chloro-2-fluorophenyl)-1H-indazol-1-yl)-2-fluorobenzamido)thiazole-5-carboxylate.

19. A pharmaceutical composition for treating sodium channel blocker-related diseases, comprising the compound according to claim 1 or a pharmaceutically acceptable salt thereof as an active ingredient.

20. The pharmaceutical composition according to claim 19 , wherein the sodium channel blocker-related diseases is selected from the group consisting of acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, and paroxysmal extreme pain disorder (PEPD).