Automatic process platform for the production of astatine-211 [At 211] radiopharmaceuticals
A system and method for automatic production of astatine-211 labeled molecules is described. The invention represents a significant advantage in the preparation of At-211 radiopharmaceuticals including better reproducibility, reduced production time and increased radiation safety. The invention also enables routine automatic synthesis of radiopharmaceuticals in a clinical setting, in conjunction or at short distance from a cyclotron unit capable of producing the radionuclide.
1. An automatic system for controlling a process for production of At-211-labeled molecules from target material containing At-211 in solid form, characterized in that the automatic system comprises:
a scraping unit ( 120 ) for scraping an irradiated bismuth target to At-211 powder ( 125 ) target material,
a receptacle ( 100 ) for receiving a powder of At-211,
a furnace ( 101 ) for vaporization of the At-211 powder by heating the receptacle ( 100 ),
a cooling unit ( 106 ) for indirectly condensing the vaporized At-211 to obtain At-211 as a dry residue in condensation capillary ( 104 ) coiled around heat transfer insertion ( 230 ),
a transfer liquid container ( 107 ) containing a transfer liquid for eluting the At-211,
a reaction vial ( 109 ) for further chemical processing of the At-211,
a three way valve ( 105 ) connecting the receptacle ( 100 ) with a capillary system including a plurality of capillaries comprising condensation capillary 104 and transfer liquid capillary ( 108 ) for transportation of the vaporized At-211 to the cooling unit ( 106 ) and further to the reaction vial ( 109 ), and for transportation of the transfer liquid from the liquid container ( 107 ) to the cooling unit ( 106 ),
a vacuum pump ( 201 ) arranged to reduce the pressure in the condensation capillary ( 104 ), reaction vial ( 109 ) and receptacle ( 100 ) to achieve an underpressure in the automatic system for transportation of the At-211,
valves ( 205 ) for transport of transfer liquid and further chemical processing of the At-211,
a capillary ( 112 ) for transportation of reagent from a reagent container ( 111 ) to the reaction vial ( 109 ),
a gas flow device ( 208 ) arranged to introduce a gas flow into the receptacle ( 100 ), and into a capillary and valve system comprising, for distillation, capillaries ( 104 , 108 ) and three way valve ( 105 ), and for synthesis, reagent capillary ( 112 ) and valves ( 205 ) for assisting in transportation of the At-211, the transfer liquid, reagents and solvents,
one or more radioactivity detectors ( 400 , 401 , 402 , 403 , 404 ) for measuring the radioactivity at one or more locations in the automatic system, and
one control unit ( 140 ), the control unit ( 140 ) configured to control the transportation of the At-211, the transfer liquid, reagents and product in the capillary and valve system by generating control commands to the vacuum pump and the gas flow device based on input data from the radioactivity detectors corresponding to measured radioactivity at said one or more locations in the automatic system.
2. The system according to claim 1 , wherein the control unit is configured to generate the control commands to the vacuum pump ( 201 ) and the gas flow device ( 208 ) based on the input data from the radioactive detectors ( 400 , 401 , 402 , 403 , 404 ) and predefined limit values for the radioactivity at said locations in the system.
3. The system according to claim 1 , wherein the system further comprises at least one pressure sensor ( 206 ) for sensing the pressure in the capillary system, and the control unit ( 140 ) is configured to generate the control commands to the vacuum pump ( 201 ) based on input data from the radioactive detectors and input data from the at least one pressure sensor.