Pharmaceutically active compounds

1. A compound of formula (I):

wherein

one of Q 1 and Q 2 represents a nitrogen atom and the other represents CH, or both Q 1 and Q 2 represent nitrogen atoms, and Q 3 represents CH;

A represents an optionally substituted five- or six-membered aromatic ring;

R 1 represents an aliphatic carbocyclic or heterocyclic ring, optionally substituted by —(C═O) x NR a R b , —OR c , —SO 2 R g or optionally substituted alkyl, in which

x is 0 or 1;

R a and R b independently represent (a) H, (b) optionally substituted alkyl, (c) optionally substituted cycloalkyl, (d) optionally substituted heterocycloalkyl, (e) —(C═O)R d , or (f) —SO 2 R e , wherein R d and R e independently represent (i) optionally substituted alkyl, (ii) optionally substituted alkoxy, or (iii) optionally substituted cycloalkyl; or R a and R b together with the nitrogen atom to which they are attached form an optionally substituted aromatic or aliphatic heterocyclic ring;

R c represents optionally substituted alkyl;

and

R g represents optionally substituted cycloalkyl;

R 2 represents H, optionally substituted alkyl or halo;

R 3 represents an optionally substituted aryl or heteroaryl ring;

R 5 and R 6 independently represent H or optionally substituted alkyl; or R 5 and R 6 together with the carbon atom to which they are attached form an optionally substituted cycloalkyl ring, optionally containing a heteroatom;

and the corresponding N-oxides; and pharmaceutically acceptable salts and solvates of such compounds and their N-oxides and prodrugs.

2. A compound according to claim 1 , which is of formula (Ic):

wherein

one of Q 1 and Q 2 represents a nitrogen atom and the other represents CH, or both Q 1 and Q 2 represent nitrogen atoms;

Q 4 represents CH or a nitrogen atom;

R 1 represents a six-membered aliphatic carbocyclic or heterocyclic ring, optionally substituted by —(C═O) x NR a R b , —OR c , —SO 2 R g or C 1-6 alkyl, in which

x is 0 or 1;

R a and R b independently represent (a) H, (b) C 1-6 alkyl optionally substituted by C 1-6 alkoxy, (c) C 3-6 cycloalkyl optionally substituted by C 1-6 alkyl, (d) a 3- to 6-membered heterocycloalkyl ring optionally substituted by C 1-6 alkyl, (ie) —(C═O)R d , or (f) —SO 2 R e , wherein R d and R e independently represent (i) C 1-6 alkyl optionally substituted by cycloalkyl or halo, (ii) C 1-6 alkoxy, or (iii) C 3-6 cycloalkyl optionally substituted by C 1-6 alkyl; or R a and R b together with the nitrogen atom to which they are attached form a 5- or 6-membered aromatic or aliphatic heterocyclic ring optionally substituted by oxo or C 1-6 alkyl;

R c represents C 1-6 alkyl;

and

R g represents C 3-6 cycloalkyl;

R 2 represents H, C 1-6 alkyl or halo;

R 3 represents a 5- or 6-membered aryl or heteroaryl ring, optionally substituted by C 1-6 alkyl or halo;

R 4 represents H, halo or —OR f , where R f is C 1-6 alkyl;

R 5 and R 6 independently represent H or C 1-6 alkyl optionally substituted by halo; or R 5 and R 6 together with the carbon atom to which they are attached form a 3- or 4-membered cycloalkyl ring, optionally containing a heteroatom and optionally substituted by —OH, C 1-6 alkyl or halo;

and the corresponding N-oxides; and pharmaceutically acceptable salts and solvates of such compounds and their N-oxides and prodrugs.

3. A compound according to claim 2 , wherein R 1 represents a six-membered aliphatic carbocyclic ring, optionally substituted by —(C═O) x NR a R b .

4. A compound according to claim 3 , wherein x is 0.

5. A compound according to claim 4 , wherein R a and/or R b represent:

(a) C 1-6 alkyl optionally substituted by —OCH 3 ; or

(b) cyclopropyl or cyclobutyl, any of which is optionally substituted by C 1-6 alkyl; or

(c) a 4-membered heterocycloalkyl ring, optionally substituted by C 1-6 alkyl; or

(d) —(C═O)R d ; or

(e) —SO 2 R e .

6. A compound according to claim 2 , wherein R a and R b , together with the nitrogen atom to which they are attached, form a 5- or 6-membered aromatic or aliphatic heterocyclic ring selected from triazinyl, oxazolidinyl, pyrrolidinyl, piperidinyl and morpholinyl, any of which may be optionally substituted by oxo or C 1-6 alkyl.

7. A compound according to claim 2 , wherein one of R a and R b represents H or C 1-6 alkyl optionally substituted by C 1-6 alkoxy, while the other of R a and R b represents (i) C 1-6 alkyl optionally substituted by C 1-6 alkoxy, (ii) C 3-6 cycloalkyl optionally substituted by C 1-6 alkyl, (iii) a 3- to 6-membered heterocycloalkyl ring optionally substituted by C 1-6 alkyl, (v) —(C═O)R d , or (vi) —SO 2 R e .

8. A compound according to claim 7 , wherein R d and/or R e represent:

(a) —CH 3 , —CHF 2 , —C(CH 3 ) 2 CF 3 , —C(CH 3 ) 3 , —CH 2 C(CH 3 ) 3 , —CH(CH 3 ) 2 , —CH 2 CH 3 or —CH 2 CH 2 CH 3 ; or C 1-6 alkyl optionally substituted by cycloalkyl, halo or alkoxy

(b) C 1-6 alkyl optionally substituted by cyclopropyl or cyclobutyl; or

(c) —OCH 3 or —OCH 2 CH 3 ; or

(d) C 3-6 cycloalkyl optionally substituted by C 1-6 alkyl.

9. A compound according to claim 2 , wherein R c represents methyl.

10. A compound according to claim 2 , wherein R g represents cyclopropyl.

11. A compound according to claim 2 , wherein R 2 is selected from H, methyl, and F.

12. A compound according to claim 2 , wherein R 3 is selected from phenyl optionally substituted by C 1-6 alkyl or halo; thienyl optionally substituted by C 1-6 alkyl or halo; and pyridyl optionally substituted by C 1-6 alkyl or halo.

13. A compound according to claim 2 , wherein R 4 is selected from H and halo.

14. A compound according to claim 2 , wherein R 5 and/or R 6 represent methyl optionally substituted by F.

15. A compound according to claim 2 , wherein R 5 and R 6 , together with the carbon atom to which they are attached, form a cyclopropyl or cyclobutyl ring, optionally substituted by —OH, C 1-6 alkyl and/or F.

16. A compound according to claim 15 , wherein R 5 and R 6 , together with the carbon atom to which they are attached, form 2,2-difloro-cyclobutyl or 2-methyl-2-hydroxy-cyclobutyl.

17. A compound according to claim 15 , wherein R 5 and R 6 , together with the carbon atom to which they are attached, form a 3- or 4-membered cycloalkyl ring, containing a heteroatom selected from N, O and S, and optionally substituted by —OH, C 1-6 alkyl and/or halo.

18. A compound according to claim 17 , wherein R 5 and R 6 , together with the carbon atom to which they are attached, form an oxetanyl ring, optionally substituted by —OH, C 1-6 alkyl and/or halo.

19. A compound according to claim 1 , which is of formula (Id):

wherein

one of Q 1 and Q 2 represents a nitrogen atom and the other represents CH, or both Q 1 and Q 2 represent nitrogen atoms;

R a and R b independently represent (a) H, (b) optionally substituted alkyl, (c) optionally substituted cycloalkyl, (d) optionally substituted heterocycloalkyl, (e) —(C═O)R d , or (f) —SO 2 R e , wherein R d and R e independently represent (i) optionally substituted alkyl, (ii) alkoxy, or (iii) optionally substituted cycloalkyl; or R a and R b together with the nitrogen atom to which they are attached form an optionally substituted aromatic or aliphatic heterocyclic ring;

R 2 is H, optionally substituted alkyl or halo;

R 3 is an optionally substituted aryl or heteroaryl ring;

R 5 and R 6 independently represent H or optionally substituted alkyl; or R 5 and R 6 together with the carbon atom to which they are attached form an optionally substituted cycloalkyl ring, optionally containing a heteroatom;

and the corresponding N-oxides; and pharmaceutically acceptable salts and solvates of such compounds and their N-oxides and prodrugs.

20. A compound according to claim 1 , which is of formula (Ie):

wherein

one of Q 1 and Q 2 represents a nitrogen atom and the other represents CH, or both Q 1 and Q 2 represent nitrogen atoms;

R 5 and R 6 independently represent H or optionally substituted alkyl; or R 5 and R 6 together with the carbon atom to which they are attached form an optionally substituted cycloalkyl ring, optionally containing a heteroatom;

R 7 represents alkyl, alkoxy or cycloalkyl;

and the corresponding N-oxides; and pharmaceutically acceptable salts and solvates of such compounds and their N-oxides and prodrugs.

21. A compound according to claim 1 , which is selected from the group consisting of:

and the corresponding N-oxides; and pharmaceutically acceptable salts and solvates of such compounds and their N-oxides and prodrugs.

22. A compound according to claim 1 , which is selected from the group consisting of:

N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylisobutyramide;

N-(6-(4-(1-amino-3,3-difluorocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-((S)-1-aminoethyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-((R)-1-aminoethyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-(2-fluorophenyl)pyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-((S)-1-amino-2,2-difluoroethyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-(trans-1-amino-3-hydroxycyclobutyl)phenyl)-5-phenylpyridin-3-yl)acetamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-(3-aminooxetan-3-yl)phenyl)-5-phenylpyridin-3-yl)acetamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-phenylpyridin-3-yl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-(2-fluorophenyl)pyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)-2-(trans-4-(N-methylmethylsulfonamido)cyclohexyl)acetamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-(1-aminocyclobutyl)phenyl)-5-(2-methylthiophen-3-yl)pyridin-3-yl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-(4-methylthiophen-3-yl)pyridin-3-yl)-2-(trans-4-(N-methylmethylsulfonamido)cyclohexyl)acetamide;

N-(trans-4-(2-((2-(4-(1-aminocyclobutyl)phenyl)-[3,3′-bipyridin]-5-yl)amino)-2-oxoethyl)cyclohexyl)-3,3,3-trifluoro-2,2-dimethylpropanamide;

N-(6-(4-(3-aminooxetan-3-yl)phenyl)-5-phenylpyridin-3-yl)-2-(4-methoxycyclohexyl)acetamide;

N-(6-(4-(3-aminooxetan-3-yl)phenyl)-5-phenylpyridin-3-yl)-2-((2R,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(3-methyl-4H-1,2,4-triazol-4-yl)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-(1-amino-3,3-difluorocyclobutyl)phenyl)-5-phenylpyridin-3-yl)acetamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)cyclopropanecarboxamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclopropanecarboxamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(2-oxopiperidin-1-yl)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(2-cyclopropylacetamido)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)-3-fluorophenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(5-(4-(1-aminocyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(methyl(3-methyloxetan-3-yl)amino)cyclohexyl)acetamide;

N-(6-(4-(3-aminooxetan-3-yl)phenyl)-5-phenylpyridin-3-yl)-2-(4,4-dimethoxycyclohexyl)acetamide;

N-(6-(4-(3-aminooxetan-3-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(cyclopropanesulfonamido)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)-2-(trans-4-morpholinocyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)-2-(trans-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(1-(cyclopropylsulfonyl)piperidin-4-yl)-2-fluoroacetamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)propanamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(6′-(2-aminopropan-2-yl)-3-phenyl-[2,3′-bipyridin]-5-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclobutanecarboxamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)-2-(trans-4-(2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-isopropylacetamido)cyclohexyl)acetamide;

(S)—N-(6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(1-(cyclopropylsulfonyl)piperidin-4-yl)-2-fluoroacetamide;

methyl(trans-4-(2-((6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(isopropyl)carbamate;

methyl(trans-4-(2-((6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-1-fluoro-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)-3-fluorophenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclopropanecarboxamide;

methyl(trans-4-(1-((6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-1-oxopropan-2-yl)cyclohexyl)(methyl)carbamate;

trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)-N,N-dimethylcyclohexane-1-carboxamide;

methyl(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

methyl(trans-4-(2-((6-(4-(1-amino-3,3-difluorocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(6-(4-(1-amino-3,3-difluorocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(1-aminocyclopropyl)-3-fluorophenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl(methyl)carbamate;

N-(5-(4-(2-aminopropan-2-yl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(5-(4-(2-aminopropan-2-yl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

methyl(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(2-fluorophenyl)-1,2,4-triazin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenyl-1,2,4-triazin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(5-(4-(1-aminocyclobutyl)phenyl)-4-(thiophen-3-yl)pyridin-2-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclopropanecarboxamide;

N-(6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(1-amino-3,3-difluorocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;

N-(6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(5′-(4-(1-aminocyclobutyl)phenyl)[2,4′-bipyridin]-2′-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

Methyl(trans-4-(2-((6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(1-aminocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

methyl(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylisobutyramide;

methyl (trans-4-(2-((5′-(4-(1-aminocyclobutyl)phenyl)-[2,4′-bipyridin]-2′-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclopropanecarboxamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

methyl(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-(thiophen-3-yl)pyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)-3-fluorophenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(trans-4-(2-((6-(4-(trans- 1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(6-(4-(1-aminocyclopropyl)-3-fluorophenyl)-5-(thiophen-3-yl)pyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-(thiophen-3-yl)pyridin-2-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-(2-fluorophenyl)pyridin-2-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-(2-fluorophenyl)pyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

methyl(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-(2-fluorophenyl)pyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

ethyl(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylisobutyramide;

N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(N-isopropylacetamido)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(isopropyl)carbamate;

N-(5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(N-isopropylacetamido)cyclohexyl)acetamide;

methyl(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)carbamate;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-isopropylpropionamide;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-isopropylcyclopropanecarboxamide;

N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(N-ethylacetamido)cyclohexyl)acetamide;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-2-methoxy-N-methylacetamide;

N-(5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(N-ethylacetamido)cyclohexyl)acetamide;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-2,2-difluoro-N-methylacetamide;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-(thiophen-3-yl)pyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(5-(4-(trans- 1-amino-3-hydroxy-3-methylcyclobutyl)-3-fluorophenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)-3-fluorophenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-ethylpropionamide;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-ethylcyclopropanecarboxamide;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-ethylpropionamide;

methyl(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(ethyl)carbamate;

N-(5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(N-(2,2,2-trifluoroethyl)acetamido)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(ethyl)carbamate;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-ethylpropionamide;

N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-isopropylacetamido)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(isopropyl)carbamate;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-isopropylpropionamide;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)-3-fluorophenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)-3-fluorophenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)-3-fluorophenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)acetamide; and

methyl(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(ethyl)carbamate.

23. A compound according to claim 1 , which is selected from the group consisting of:

methyl(trans-4-(2-((6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(6-(4-(1-amino-3,3-difluorocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-morpholinocyclohexyl)acetamide;

N-(6-(4-(1-amino-3,3-difluorocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(1-amino-3,3-difluorocyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((6-(4-(1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-2,2-difluoroacetamide;

N-(trans-4-(2-((6-(4-(3-aminooxetan-3-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-3,3,3-trifluoro-2,2-dimethylpropanamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-2,2-difluoro-N-methylacetamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-((S)-1-aminoethyl)phenyl)-5-phenylpyridin-3-yl)acetamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-((R)-1-aminoethyl)phenyl)-5-phenylpyridin-3-yl) acetamide;

N-(trans-4-(2-((6-(4-((S)-1-aminoethyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-3,3,3-trifluoro-2,2-dimethylpropanamide;

N-(trans-4-(2-((6-(4-((R)-1-aminoethyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-3,3,3-trifluoro-2,2-dimethylpropanamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-((S)-1-amino-2,2-difluoroethyl)phenyl)-5-phenylpyridin-3-yl)acetamide;

N-(6-(4-((S)-1-aminoethyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylmethylsulfonamido)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)-2-(trans-4-(2-oxopiperidin-1-yl)cyclohexyl)acetamide;

N-(6-(4-(trans- 1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-morpholinocyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-(2-fluorophenyl)pyridin-3-yl)-2-(trans-4-(N-methylmethylsulfonamido)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(3-methyl-4H-1,2,4-triazol-4-yl)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-morpholinocyclohexyl)acetamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)acetamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)cyclopropanecarboxamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-1-methylcyclopropane - 1-carboxamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)isobutyramide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)-2-(trans-4-(N-methylmethylsulfonamido)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylmethylsulfonamido)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-(2-fluorophenyl)pyridin-3-yl)-2-(trans-4-(N-methylmethylsulfonamido)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(2-aminopropan-2-yl)-3-fluorophenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclopropanecarboxamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N,3,3-trimethylbutanamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N,1-dimethylcyclopropane-1-carboxamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-2-cyclopropyl-N-methylacetamide;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylbutyramide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)pivalamide;

N-(trans-4-(2-((6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-2,2-difluoroacetamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)cyclobutanecarboxamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-3,3-dimethylbutanamide;

2-(trans-4-acetamidocyclohexyl)-N-(6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)acetamide;

N-(trans-4-(2-((6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)cyclopropanecarboxamide;

N-(trans-4-(2-((6-(4-(1-aminocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)pivalamide;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)butyramide;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-2,2-difluoroacetamide;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)pivalamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-isopropylacetamido)cyclohexyl)acetamide;

methyl(trans-4-(1-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-1-oxopropan-2-yl)cyclohexyl)(methyl)carbamate;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(morpholine-4-carbonyl)cyclohexyl)acetamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(pyrrolidine-1-carbonyl)cyclohexyl)acetamide;

methyl(trans-4-(2-((5-(4-(2-aminopropan-2-yl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(5-(4-(2-aminopropan-2-yl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclopropyl)-3-fluorophenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(5-(4-(1-aminocyclopropyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(5-(4-(2-aminopropan-2-yl)phenyl)-4-(thiophen-3-yl)pyridine-2-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(5-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclopropyl)-3-fluorophenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide;

N-(5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(5-(4-((1r,3r)-1-amino-3-fluorocyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

methyl(trans-4-(2-((6-(4-(trans-1-amino-3-fluorocyclobutylphenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

methyl(trans-4-(2-((5-(4-(1-aminocyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(5-(4-(1-aminocyclobutyl)phenyl)-4-(2-fluorophenyl)pyridin-2-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

methyl(trans-4-(2-((5-(4-(1-aminocyclobutyl)phenyl)-4-(2-fluorophenyl)pyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(5-(4-(1-aminocyclobutyl)phenyl)-4-(thiophen-3-yl)pyridin-2-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(5-(4-(1-aminocyclobutyl)phenyl)-4-(2-fluorophenyl)pyridin-2-yl)-2-(trans-4-(2-oxooxazolidin-3-yl)cyclohexyl)acetamide; methyl(trans-4-(2-((6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

methyl(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

methyl(trans-4-(2-((6-(4-(1-aminocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

methyl(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

methyl(trans-4-(2-((6-(4-(trans-1-amino-3-fluorocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(5-(4-(1-aminocyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;

N-(trans-4-(2-((5-(4-(1-aminocyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclopropanecarboxamide;

ethyl(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

isopropyl(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclopropanecarboxamide;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclobutanecarboxamide;

methyl(trans-4-(2-((6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclopropanecarboxamide;

N-(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylisobutyramide;

ethyl(trans-4-(2-((6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((5-(4-(1-aminocyclopropyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;

N-(5-(4-(1-aminocyclopropyl)phenyl)-4-phenylpyridin-2-yl)-2-(trans-4-(2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylisobutyramide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclopropanecarboxamide;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclobutanecarboxamide;

methyl(trans-4-(2-((5′-(4-(1-aminocyclopropyl)phenyl)-[2,4′-bipyridin]-2′-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(6-(4-(1-aminocyclopropyl)-3-fluorophenyl)-5-phenylpyridin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

ethyl(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-(thiophen-3-yl)pyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylisobutyramide;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylcyclobutanecarboxamide;

ethyl(trans-4-(2-((6-(4-(1-aminocyclopropyl)phenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(6-(4-(2-aminopropan-2-yl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(1-aminocyclobutyl)phenyl)-5-(thiophen-3-yl)pyridazin-3-yl)-2-(trans-4-(N-methylacetamido)cyclohexyl)acetamide;

N-(6-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-phenylpyridazin-3-yl)-2-(trans-4-(2-oxopiperidin-1-yl)cyclohexyl)acetamide;

ethyl(trans-4-(2-((6-(4-(2-aminopropan-2-yl)phenyl)-5-phenylpyridin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

methyl(trans-4-(2-((6-(4-(1-aminocyclopropyl)-3-fluorophenyl)-5-(thiophen-3-yl)pyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)-3-fluorophenyl)-5-(thiophen-3-yl)pyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(trans-4-(2-((5-(4-(1-aminocyclobutyl)phenyl)-4-(2-fluorophenyl)pyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

N-(trans-4-(2-((6-(4-(1-aminocyclopropyl)-3-fluorophenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)-N-methylpropionamide;

methyl(trans-4-(2-((6-(4-(1-aminocyclopropyl)-3-fluorophenyl)-5-phenylpyridazin-3-yl)amino)-2-oxoethyl)cyclohexyl)(methyl)carbamate;

methyl(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)(isopropyl)carbamate;

methyl(trans-4-(2-((5-(4-(1-aminocyclopropyl)-3-fluorophenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)carbamate;

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-isopropylpropionamide; and

N-(trans-4-(2-((5-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-4-phenylpyridin-2-yl)amino)-2-oxoethyl)cyclohexyl)-N-isopropylcyclopropanecarboxamide.

24. A method of treating cancer, comprising administering a therapeutically effective amount of a compound according to claim 1 , to a subject with cancer.

25. The method according to claim 24 , wherein the cancer is lung cancer, melanoma, breast cancer, ovarian cancer or carcinoma.

26. The method according to claim 24 , wherein the method further comprises administering one or more chemotherapeutic agents.

27. A method of treating pheochromocytoma; inflammatory conditions, endometriosis, vascular disease/injury, psoriasis, visual impairment due to macular degeneration, diabetic retinopathy, retinopathy of prematurity, kidney disease, pulmonary disorders, osteoporosis, osteoarthritis, viral infections, fibrotic disease, cataracts, infant tauopathies, tuberous sclerosis complex, focal cortical dysplasia 2 or ganglioglioma comprising administering a therapeutically effective amount of a compound of claim 1 to a subject in need thereof.

28. A pharmaceutical composition comprising a compound according to claim 1 and one or more pharmaceutically acceptable excipients.