Donepezil derivative and use thereof
The present invention relates to a donepezil derivative of general formula (I) or a pharmaceutically acceptable salt thereof, wherein R in the formula is as disclosed herein; and a method for preparation thereof; and a composition comprising an effective amount of a compound of the general formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to use of a compound of the general formula (I) or a pharmaceutically acceptable salt thereof in preparing a medicament for treating a disease resulted from an abnormality in acetylcholinesterase activity.
1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein R is C 7 alkyl group.
2. A method of treating dementia in a patient, comprising:
administering a compound according to claim 1 or a pharmaceutically acceptable salt thereof to said patient.
3. A pharmaceutical composition, comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
4. The pharmaceutical composition of claim 3 , wherein the excipient is selected from one or more of castor oil, soybean oil, sesame oil, arachis oil, corn oil, cottonseed oil, or glycerides.
5. The pharmaceutical composition of claim 3 , further comprising a hydrotropic agent, the hydrotropic agent being selected from one or more of benzyl benzoate or alcohols.
6. The pharmaceutical composition according to claim 3 , further comprising a pain relief agent, the pain relief agent being selected from benzyl alcohol.
7. The pharmaceutical composition of claim 4 , wherein the excipient is castor oil.
8. The pharmaceutical composition of claim 5 , wherein the hydrotropic agent is benzyl benzoate.