Factor IXa inhibitors

1. A compound of Formula I:

wherein A is selected from:

R 1 is phenyl, which is optionally substituted with halo, R 5 , (C═O)OR 5 , (C═O)NR 5 R 6 or C 1-3 alkyl(C═O)OR 5 ; or heteroaryl, which is optionally substituted with one or two substituents independently selected from the group consisting of halo, oxo, R 5 , OR 5 , NR 5 R 6 and C 1-3 alkyl-NR 5 R 6 ;

R 2 is hydrogen or C 1-6 alkyl;

R 3 is heteroaryl, which is optionally substituted with one or two substituents independently selected from the group consisting of halo, oxo, cyclopropyl, R 5 , OR 5 , (C═O)OR 5 and CH 2 SO 2 CH 3 ;

each R 4 is independently selected from halo, R 5 or OR 5 ,

each R 5 is hydrogen or C 1-6 alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxy;

R 6 is hydrogen, cyclopropyl or C 1-6 alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxy;

R a is hydrogen, halo, C 1-6 alkyl or O(C 1-6 alkyl);

R b is hydrogen, halo, C 1-6 alkyl or O(C 1-6 alkyl);

R c is hydrogen, halo, C 1-6 alkyl or O(C 1-6 alkyl);

R d is hydrogen, halo, C 1-6 alkyl or O(C 1-6 alkyl);

R e is hydrogen, halo, C 1-6 alkyl or O(C 1-6 alkyl);

R f is hydrogen, halo, C 1-6 alkyl or O(C 1-6 alkyl);

R g is hydrogen, halo, C 1-6 alkyl or O(C 1-6 alkyl);

R h is hydrogen, halo, C 1-6 alkyl or O(C 1-6 alkyl);

n is an integer between zero and two;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 wherein A is

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 wherein R 1 is phenyl, which is optionally substituted with halo, (C═O)OR 5 , (C═O)NR 5 R 6 or C 1-3 alkyl(C═O)OR 5 , or a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 wherein R 1 is phenyl, which is optionally substituted with halo, or a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 wherein R 2 is hydrogen, or a pharmaceutically acceptable salt thereof.

6. The compound of claim 1 wherein R 4 is halo; n is 2; or a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 wherein R 3 is 1,2,3-triazolyl, 1,2,4-triazolyl, imidazolyl, tetrazolyl, pyridyl, pyrimidinyl, pyrazolyl, pyridazinyl, quinolinyl, triazolopyridinyl, triazolonyl, pyridinyl or benzoimidazolyl, wherein said groups are optionally substituted with halo, oxo, cyclopropyl, R 5 , OR 5 , (C═O)OR 5 or CH 2 SO 2 CH 3 , or a pharmaceutically acceptable salt thereof.

8. A compound selected from

(R)-2,6-Dichloro-N-(2-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-2-phenylethyl)-4-(4-(2-hydroxyethyl)-1H-1,2,3-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(1H-tetrazol-1-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-[4-(2-hydroxyethyl)-1H-1,2,3-triazol-1-yl]benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)-6-(trifluoromethyl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)-6-(trifluoromethyl)benzamide;

(R)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-6-methyl-4-(3-methyl-1,2,4-triazol-1-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-6-methoxy-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-6-fluoro-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-6-methyl-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(1H-tetrazol-1-yl)benzamide;

(R)-2-chloro-N-[2-(6-chloro-1H-benzimidazol-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methoxy-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)-6-(trifluoromethoxy)benzamide;

(R)-2-chloro-N-[2-(6-chloro-4-methyl-1H-benzimidazol-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-4H-1,2,4-triazol-4-yl)benzamide;

(±)-4-(3,5-dichloro-4-{[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]carbamoyl}phenyl)pyridine-2-carboxylic acid;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-pyrimidin-5-ylbenzamide;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-{-[(methyl sulfonyl)methyl]-1H-pyrazol-4-yl}benzamide;

(±)-ethyl 4-(3,5-dichloro-4-{[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]carbamoyl}phenyl)pyridine-2-carboxylate;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)benzamide;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-[2-(2-fluoroethoxy)pyrimidin-5-yl]benzamide;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-[5-(1-hydroxy-1-methylethyl)pyridin-3-yl]benzamide;

(±)-methyl 5-(3,5-dichloro-4-{[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]carbamoyl}phenyl)pyridine-2-carboxylate;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)benzamide;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-quinolin-3-ylbenzamide;

(±)-5-(3,5-dichloro-4-{[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]carbamoyl}phenyl)pyridine-2-carboxylic acid;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-[1,2,4]triazolo[4,3-a]pyridin-6-ylbenzamide;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-[1,2,4]triazolo[1,5-a]pyridin-7-ylbenzamide;

(±)-2,6-dichloro-4-(2-cyclopropylpyrimidin-5-yl)-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]benzamide;

(±)-ethyl 4-(3-chloro-4-{[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]carbamoyl}phenyl)pyridine-2-carboxylate;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]benzamide;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(1H-pyrazol-4-yl)benzamide;

(±)-4-(3-chloro-4-{[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]carbamoyl}phenyl)pyridine-2-carboxylic acid;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-[5-(hydroxymethyl)pyridin-3-yl]benzamide;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-[6-(hydroxymethyl)pyridin-3-yl]benzamide;

(±)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-[2-(hydroxymethyl)pyridin-4-yl]benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-(5-fluoropyridin-3-yl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(±)-2,6-dichloro-N-[2-(6-chloro-1H-benzimidazol-2-yl)-2-(6-oxo-1,6-dihydropyridin-3-yl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(±)-2,6-Dichloro-N-(2-(6-chloro-1H-benzo[d]imidazol-2-yl)-2-(6-methoxypyridin-3-yl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-4-(1-(6-Chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-(2,6-dichloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamido)ethyl)benzoic acid;

(R)-4-(1-(6-Chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-(2,6-dichloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamido)ethyl)benzoic acid;

(R)-2,6-Dichloro-N-(2-(6-chlorobenzo[d]oxazol-2-yl)-2-(4-fluorophenyl)ethyl)-4-(4H-1,2,4-triazol-4-yl)benzamide;

(±)-2-chloro-N-[2-(5-methyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(±)-2-chloro-N-[2-(4-methyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2,6-dichloro-N-[2-(6-chloro-1H-benzimidazol-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-[2-(6-chloro-4-methyl-1H-benzimidazol-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-[2-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-[2-(3-fluorophenyl)-2-(6-methoxy-1H-benzimidazol-2-yl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-(3-fluorophenyl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-(2-fluorophenyl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2,6-dichloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2,6-dichloro-N-[2-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(±)-2-chloro-N-{2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2-chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-pyridin-3-ylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2,6-dichloro-N-{2-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-[2-(dimethylamino)pyrimidin-5-yl]ethyl}-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)—N-[2-(4-carbamoylphenyl)-2-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)ethyl]-2,6-dichloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-3-[1-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-({[2,6-dichloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]carbonyl}amino)ethyl]benzoic acid;

(R)-4-[1-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-({[2,6-dichloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]carbonyl}amino)ethyl]benzoic acid;

(R)-2,6-dichloro-N-{2-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-[3-(methylcarbamoyl)phenyl]ethyl}-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-{3-[1-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-({[2,6-dichloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]carbonyl}amino)ethyl]phenyl}acetic acid;

(R)-2,6-dichloro-N-{2-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-[4-(dimethylcarbamoyl)phenyl]ethyl}-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-methyl {3-[1-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-({[2,6-dichloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]carbonyl}amino)ethyl]phenyl}acetate;

(R)-ethyl 4-[1-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-({[2,6-dichloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]carbonyl}amino)ethyl]benzoate;

(R)-ethyl 3-[1-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-({[2,6-dichloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]carbonyl}amino)ethyl]benzoate;

(R)-2,6-dichloro-N-{2-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-[3-(cyclopropylcarbamoyl)phenyl]ethyl}-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(±)-2-chloro-N-[2-[5,6-dimethyl-1,3-benzoxazol-2-yl)-2-(3-fluorophenyl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-(2-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-2-phenylpropyl)-4-(4H-1,2,4-triazol-4-yl)benzamide;

((R)-2,6-Dichloro-N-(2-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-2-(4-fluorophenyl)propyl)-4-(4H-1,2,4-triazol-4-yl)benzamide;

(±)-2,6-Dichloro-N-(2-(6-chloro-5-methoxy-1H-benzo[d]imidazol-2-yl)-2-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(±)-6-dichloro-N-[2-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-{4-[(dimethylamino)methyl]-1H-1,2,3-triazol-1-yl}ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(±)-2,6-dichloro-N-{2-(6-chloro-5-methoxy-1H-benzimidazol-2-yl)-2-[4-(1-hydroxy-1-methylethyl)-1H-1,2,3-triazol-1-yl]ethyl}-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-(2-(5,6-dimethyl-1H-indol-2-yl)-2-phenylethyl)-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2,6-dichloro-N-(2-(3-fluorophenyl)-2-(2-methyl-1H-benzo[d]imidazol-5-yl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(S)-2,6-dichloro-N-(2-(3-fluorophenyl)-2-(2-methyl-3H-imidazo[4,5-b]pyridin-6-yl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(S)-2,6-dichloro-N-[2-(3-fluorophenyl)-2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(S)-2,6-dichloro-N-[2-(4-fluoro-2-methyl-1H-benzimidazol-5-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(S)-2,6-dichloro-N-[2-(7-fluoro-2-methyl-1H-benzimidazol-5-yl)-2-(3-fluorophenyl);

(R)-2,6-dichloro-N-[2-(3-fluorophenyl)-2-(2-methyl-1H-imidazo[4,5-b]pyridin-5-yl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(±)-2,6-dichloro-N-[2-(3-fluorophenyl)-2-(2-methyl-3H-imidazo[4,5-c]pyridin-6-yl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(S)-2,6-dichloro-N-[2-(2,7-dimethyl-1H-benzimidazol-5-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-(2-(3-fluorophenyl)-2-(2-methylbenzo[d]thiazol-5-yl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2-chloro-N-(2-(5-methyl-2H-indazol-2-yl)-2-phenylethyl)-4-(4H-1,2,4-triazol-4-yl)benzamide;

(S)-2-chloro-N-(2-(5-methyl-1-indazol-1-yl)-2-phenylethyl)-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2,6-dichloro-4-(4-(2-hydroxyethyl)-1H-1,2,3-triazol-1-yl)-N-(2-(5-methyl-1H-indazol-1-yl)-2-(oxazol-5-yl)ethyl)benzamide;

(R)-2-chloro-N-[2-(3-fluorophenyl)-2-(6-methyl-1H-indol-3-yl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(S)-2-chloro-N-(2-(6-methyl-1H-indazol-3-yl)-2-phenylethyl)-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2,6-dichloro-N-(2-(5-methyl-2H-benzo[d][1,2,3]triazol-2-yl)-2-phenylethyl)-4-(4H-1,2,4-triazol-4-yl)benzamide;

(S)-2,6-dichloro-N-(2-(5-methyl-1H-benzo[d][1,2,3]triazol-1-yl)-2-phenylethyl)-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-Chloro-N-(2-(6-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethyl)-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2,6-dichloro-N-(2-(8-fluoro-5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3-fluorophenyl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-(2-(8-fluoro-5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-fluorophenyl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-(2-(5-chloro-8-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3-fluorophenyl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(±)-2-chloro-N-[2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(5-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(8-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(5,8-dichloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(±)-2-chloro-N-[2-(8-fluoro-5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide;

(R)-2-chloro-N-[2-(8-fluoro-5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2-chloro-N-[2-(8-fluoro-5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-1-(3-chloro-4-{[2-(5-chloro-8-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3-fluorophenyl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-6-carboxylic acid;

(R)-1-(3-chloro-4-{[2-(5-chloro-8-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3-fluorophenyl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-5-carboxylic acid;

(R)-2,6-dichloro-N-(2-(8-fluoro-5-methyl-4-oxo-1,4-dihydroquinolin-2-yl)-2-(3-fluorophenyl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-[2-(8-fluoro-5-methylquinolin-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2,6-dichloro-N-[2-(8-fluoro-4-methoxy-5-methylquinolin-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R or S)-2,6-Dichloro-N-(2-(3-fluorophenyl)-2-(5-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide 2,2,2-trifluoroacetate;

(R or S)-2,6-dichloro-N-[2-(6,7-dimethyl-3-oxo-3,4-dihydroquinoxalin-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;

(R)-2-chloro-N-(2-(8-fluoro-5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3-fluorophenyl)ethyl)-4-(pyridazin-4-yl)benzamide

(R)-2-chloro-N-(2-(8-fluoro-5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3-fluorophenyl)ethyl)-4-(4-(2-hydroxyethyl)-1H-imidazol-1-yl)benzamide

(R)-2-chloro-N-(2-(8-fluoro-5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3-fluorophenyl)ethyl)-4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzamide

(R)-2-chloro-N-(2-(8-fluoro-5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3-fluorophenyl)ethyl)-4-(1-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)benzamide

(R)-2,6-dichloro-N-(2-(8-fluoro-3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(pyridin-3-yl)ethyl)-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide

(R)-2-chloro-4-(3-(difluoromethyl)-4H-1,2,4-triazol-4-yl)-N-(2-(8-fluoro-5-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3-fluorophenyl)ethyl)benzamide

or a pharmaceutically acceptable salt thereof.

9. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

10. A method for inhibiting thrombus formation in blood or treating thrombus formation in blood comprising administering a composition of claim 9 to a mammal in need of thereof.

11. A method of treating venous thromboembolism and pulmonary embolism in a mammal comprising administering a composition of claim 9 to a mammal in need thereof.

12. A method of treating deep vein thrombosis in a mammal comprising administering a composition of claim 9 to a mammal in need thereof.

13. A method of treating thromboembolic stroke in a human comprising administering a composition of claim 9 to a mammal in need thereof.

14. A method of inhibiting Factor IXa comprising administering a composition of Compound 9 to a mammal in need thereof.