Combination drug
The present invention relates to a drug that is for treating or preventing cancer, that is effective in the treatment of cancer, and that comprises a combination of an ALK inhibitor and a VEGF inhibitor. The present invention also relates to a method for treating or preventing cancer and a method for inhibiting tumor growth.
1. A method of enhancing a therapeutic effect of an ALK inhibitor on a cancer, the method comprising: administering, in combination, an effective amount of the ALK inhibitor and an effective amount of a VEGF inhibitor to a subject in need thereof, wherein the ALK inhibitor is alectinib or a salt thereof and the VEGF inhibitor is bevacizumab and wherein said administering the effective amount of the VEGF inhibitor enhances a therapeutic effect of the ALK inhibitor on the cancer in the subject, wherein the cancer comprises a tumor that has an ALK fusion gene, the alectinib or the salt thereof is administered at a dose of 20 mg, 40 mg, 60 mg, 80 mg, 120 mg, 160 mg, 220 mg, 240 mg, 300 mg, 460 mg, 600 mg, 760 mg or 900 mg calculated as a free form twice a day and the bevacizumab is administered at 5 mg/kg, 7.5 mg/kg, 10 mg/kg or 15 mg/kg, wherein the ALK fusion gene is a fusion gene of ALK gene and EML4-gene and wherein the cancer is selected from the group consisting of non-Hodgkin's lymphoma, neuroblastoma, renal cancer, and lung cancer.
2. The method according to claim 1 , wherein the VEGF inhibitor is administered simultaneously with the ALK inhibitor.
3. The method according to claim 2 , wherein the VEGF inhibitor is administered prior to or after the administration of the ALK inhibitor.
4. The method of claim 1 , which is a method of treating the cancer.
5. The method of claim 1 , wherein the cancer is lung cancer.
6. The method of claim 4 , wherein the cancer is lung cancer.