Collagen III composition and uses
View Patent ↗The invention includes methods of suppressing cancer metastasis and local recurrence in a subject. In one aspect, the method comprises removing the tumor by surgery; and implanting a composition of the invention to the site of the primary tumor. In another aspect, the method comprises implanting a composition of the invention to a cancerous site. The composition comprises a pharmaceutically effective amount of collagen type III.
1. A method of suppressing metastasis and local recurrence of a cancer in a subject comprising:
a) removing the cancer tumor from the subject; and
b) implanting a composition to the site of tumor removed;
wherein the composition comprises a pharmaceutically effective amount of collagen type III and,
wherein the cancer is breast cancer.
2. The method of claim 1 , wherein the subject is a human.
3. The method of claim 1 , wherein the collagen type III in the composition is in the range from about 1% to about 100% by weight.
4. The method of claim 1 , wherein the collagen type III in the composition is in the range from about 20% to about 80% by weight.
5. The method of claim 1 , wherein the collagen type III in the composition is in the range from about 40% to about 60% by weight.
6. The method of claim 1 , wherein the composition further comprises a biocompatible material.
7. The method of claim 6 , wherein the biocompatible material is selected from the group consisting of alginate-poly-(L-lysine), alginate-poly-(L-lysine)-alginate, alginate-poly-(L-lysine)-polyethyleneimine, chitosan-alginate, polyhydroxylethyl-methacrylate-methyl methacrylate, carbonylmethylcellulose, K-carrageenan, chitosan, agarose-polyethersulphone-hexadi-methirine-bromide, ethyl-cellulose, silica gels, hydrogel, (meth)acrylate-oligolactide-PEO-oligolactide-(meth)acrylate, poly(ethylene oxide) (PEO), poly(propylene glycol) (PPO), PEO-PPO-PEO copolymers, poly(phosphazene), poly(methacrylates), poly(N-vinylpyrrolidone), PL(G)A-15 PEO-PL(G)A copolymers, poly(ethylene imine), poly(ethyl glycol) diacrylate, polycaprolactone, and combinations thereof.
8. The method of claim 1 , wherein the composition comprises a pharmaceutically effective amount of collagen type III, polycaprolactone, and poly(ethylene oxide) (PEO).
9. The method of claim 8 , wherein the composition is prepared by electrospinning.
10. The method of claim 1 , wherein the composition is in a formulation selected from the group consisting of a viscous liquid, a solution, a suspension, a liposomal formulation, a gel, a jelly, a cream, a lotion, an ointment, a suppository, a foam, an aerosol spray, an aqueous suspension, an oily suspensions, an aqueous solution, an oily solution, an emulsion, an emulsion ointment, and combinations thereof.
11. The method of claim 1 , wherein the composition is formulated in a gel.
12. The method of claim 1 , wherein collagen type III contains a cysteine-rich (CR) domain.
13. The method of claim 1 , wherein collagen type III does not contain a cysteine-rich (CR) domain.
14. A method of suppressing metastasis and local recurrence of a cancer in a subject comprising administering a composition to the cancerous site, wherein the composition comprises a pharmaceutically effective a mount of collagen type III, wherein the cancer is breast cancer.