Binding molecules directed against influenza hemagglutinin and uses thereof
Monomeric and multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said strains including HA of two different HA subtypes from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza B virus strain are provided. The binding molecules preferably are also capable of neutralizing at least two influenza A virus strains from phylogenetic group 2; or capable of neutralizing at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically neutralizing at least one influenza B virus strain.
1. A multi-domain antibody comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 303 and SEQ ID NO:305.
2. The multi-domain antibody according to claim 1 , comprising the amino acid sequence of SEQ ID NO:303 and the amino acid sequence of SEQ ID NO:305.
3. A multi-domain antibody comprising a first polypeptide comprising two single domain antibodies fused together via a linker, wherein the two single domain antibodies comprise the amino acid sequences of SEQ ID NOs: 155, and 176, respectively.
4. The multi-domain antibody according to claim 3 , further comprising a second polypeptide comprising two single domain antibodies fused together via a linker, wherein the two single domain antibodies comprise the amino acid sequences of SEQ ID NOs: 221 and 203, respectively.
5. The multi-domain antibody according to claim 3 , further comprising a human Fc tail.
6. A pharmaceutical composition comprising the multi-domain antibody according to claim 1 .
7. A pharmaceutical composition comprising the multi-domain antibody according to claim 3 .
8. A nucleic acid molecule encoding the multi-domain antibody according to claim 1 .
9. A nucleic acid molecule encoding the multi-domain antibody according to claim 3 .