IP Library › Granted Patent US 10,891,748
Granted Patent B2
US 10,891,748 · App. 15/549,850 · Granted Jan 12, 2021

Processing optical coherence tomography scans

Inventors: Jonathan D. Holmes (West Malling, GB); Richard Whitehead (Lingfield, GB)
Assignee: Michelson Diagnostics Ltd.
G06T7/55A61B5/0073A61B5/445G06T7/0016G06T2207/10101G06T2207/30088G06T2207/30104
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Quick Facts
Patent No.
US 10,891,748
App. No.
15/549,850
Granted
Jan 12, 2021
Kind
B2
Abstract

A method of processing optical coherence tomography (OCT) scans through a subject's skin, the method comprising: receiving a plurality of scans through the subject's skin, the scans representing an OCT signal in slices through the user's skin at different times; comparing the scans to determine time-varying regions in the scans; determining a depth-distribution of the time varying regions.

Claims (26)

1. A method of processing optical coherence tomography (OCT) scans through a subject's skin, the method comprising:

receiving a plurality of scans through the subject's skin, the scans representing an OCT signal in slices through the user's skin at different times;

comparing the scans to determine time-varying regions in the scans; and

determining a distribution of density of the time varying regions with varying depth in the scans;

determination of the time-varying regions comprising a determination of a threshold depth through the user's skin at which a density of the time-varying regions exceeds a density threshold.

2. The method of claim 1 , in which the determination of the time varying regions includes the determination of a time-varying region dependent upon a magnitude of a difference in an OCT signal between the scans that are compared.

3. The method of claim 1 in which the determination of the time-varying regions makes use of any of speckle-variance OCT, decorrelation, or differencing of intensity or phase.

4. The method of claim 1 , comprising displaying the distribution to an operator, as a graph of density of time-varying regions against depth.

5. The method of claim 1 , comprising comparing the threshold depth to a predetermined value, and giving an indication to an operator whether the threshold depth is larger or smaller than the predetermined value.

6. The method of claim 5 , in which the predetermined value is obtained from a look-up table containing values corresponding to characteristics of the subject's skin.

7. The method of claim 6 , in which the look-up table values correspond to the location of the scan on the body, the age and the gender of the subject.

8. The method of claim 1 , comprising the capturing of a plurality of calibration scans from an area of the user's skin known to be undamaged, the scans representing an OCT signal in slices through the user's skin at different times, comparing the calibration scans to determine time-varying regions in the scan, and determining a depth-distribution of the calibration scans that are occupied by time-varying regions.

9. The method of claim 8 , in which the depth distribution of time-varying regions in the calibration scans is used to determine the density threshold and/or the predetermined value.

10. The method of claim 1 , in which the comparison of the scans and the determination of the distribution of the time-varying regions is carried out using a processing device, such as a suitably programmed microprocessor.

11. The method of claim 1 , in which the step of receiving the scans comprises capturing the scans using an OCT apparatus.

12. An optical coherence tomography (OCT) image processing apparatus, comprising a processor, a display coupled to the processor and storage coupled to the processor, the storage carrying program instructions which, when executed on the processor, cause it to carry out the method of claim 1 .

13. The image processing apparatus of claim 12 , comprising an OCT apparatus by means of which the OCT scans are captured.

14. The method of claim 1 , wherein the density threshold being obtained by:

capturing a plurality of calibration scans from an area of the subject's skin known to be undamaged;

determining time varying regions from the plurality of calibration scans; and

determining a depth distribution of an area of the calibration scans occupied by the time varying regions.

15. The method of claim 1 wherein comparing the scans to determine time-varying regions in the scans comprises one of calculating a decorrelation of a local subset of pixels in OCT signal intensity in a region of interest from image to image, or calculating a statistical variance of intensity in the region of interest from image to image, or calculating difference in phase in the region of interest from image to image.

16. The method of claim 1 further comprising:

determining a position of skin's surface in the scans; and

determining depth as a distance below the position of the skin's surface.

17. The method of claim 1 further comprising displaying the distribution of density as a graph of density of time-varying regions against depth.

Assignments (2)
CORRECTIVE ASSIGNMENT TO CORRECT THE SITTINGBOURNE WAS MISSPELLED -WRONG FILE DATE-APPL NO/FILING DATE ARE SWAPPED-MICHELSON MISSPELLED PREVIOUSLY RECORDED ON REEL 044318 FRAME 0408. ASSIGNOR(S) HEREBY CONFIRMS THE ENTIRE RIGHT, TITLE AND INTEREST IN AND TO SAID INVENTION. Recorded Apr 30, 2018
From: HOLMES, JONATHAN D.; WHITEHEAD, RICHARD
To: MICHELSON DIAGNOSTICS LTD.
Reel/Frame 046221/0191 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 30, 2017
From: HOLMES, JONATHAN D.; WHITEHEAD, RICHARD
To: MICHAELSON DIAGNOSTICS, LTD
Reel/Frame 044318/0408 →
Priority Claims (1)
GB 1503196.6 · Feb 26, 2015 · national
Continuity (1)
Related Publication 20180018785A1 · Jan 18, 2018