Automatic analyzer
An automatic analyzer which is capable of detecting a dispensing abnormality with a high degree of accuracy without causing the decrease in the determination performance or the increase in the calculation amount caused by the configuration balance of the reference database is implemented. A dispensing nozzle of a sample dispensing mechanism 50 is immersed in a dispensing target contained in a specimen container 11 and sucks the dispensing target, and internal pressure of the dispensing nozzle of the sample dispensing mechanism 50 of ejecting the sucked dispensing target to a reaction container 41 is detected through a pressure sensor 54 . A plurality of feature quantities are extracted from a waveform of the detected pressure, and a determination result is output through a linear combination formula using an optimal coefficient for a determination function that receives a plurality of feature quantities and outputs one value. The determination result indicates whether or not dispensing of the sample dispensing mechanism 50 is performed normally in accordance with the magnitude of the output result of the determination function.
1. An automatic analyzer, comprising:
a reaction disk on which a plurality of reaction containers are arranged;
a sample dispensing mechanism including a sample dispensing nozzle that sucks a sample contained in a sample container and ejects the sample to a reaction container arranged on the reaction disk;
a reagent disk on which a plurality of reagent containers are arranged;
a reagent dispensing mechanism including a reagent dispensing nozzle that sucks a reagent contained in a reagent container, of the plurality of reagent containers, and ejects the reagent to the reaction container arranged on the reaction disk;
a spectroscopic detector that detects light transmitting through a solution, containing at least the reagent and the sample, contained in the reaction container;
a first pressure sensor that detects internal pressure of the sample dispensing nozzle; and
a processor programmed to control operations of the reaction disk, the sample dispensing mechanism, the reagent disk, the reagent dispensing mechanism, and the spectroscopic detector,
wherein the processor is further programmed to:
calculate a plurality of feature quantities from a waveform of the pressure of the sample dispensing nozzle detected by the first pressure sensor during a suction or ejection operation by the sample dispensing mechanism,
obtain a plurality of predetermined optimized coefficients having been optimized based on applying a cost function to predetermined reference data,
determine a determination function, which is a linear combination formula of the plurality of features quantities using the values of the optimized coefficients, and
calculate a single output value which is a result of the determination function,
determine whether or not the sample is normally sucked or ejected by the sample nozzle based on whether the calculated single output value is greater than or equal to a threshold value; and
a display device configured to display a notification when it is determined that the sample is not normally sucked or ejected.
2. The automatic analyzer according to claim 1 , further comprising:
wherein the processor is further programmed to:
when the sample is determined not to be normally sucked or ejected by the sample nozzle, cause information indicating that there is a dispensing abnormality to be displayed on the display device, and
control the reaction disk, the sample dispensing mechanism, the reagent disk, the reagent dispensing mechanism, and the spectroscopic detector such that an analysis operation for a next sample is performed.
3. The automatic analyzer according to claim 1 , further comprising:
a second pressure sensor that detects internal pressure of the reagent dispensing nozzle,
wherein the determination function is a first determination function and the single output value is a first single output value, and
wherein the processor is further programmed to:
calculate a plurality of feature quantities from a waveform of the pressure of the reagent dispensing nozzle detected by the second pressure sensor,
determine a second determination function, which is a linear combination formula of the plurality of features quantities from the waveform detected by the second pressure sensor using the values of the optimized coefficients, and
calculate a second single output value from the determination function, and
determine whether or not the reagent is normally sucked or ejected by the reagent nozzle based on the calculated second single output value.
4. The automatic analyzer according to claim 1 ,
wherein the predetermined reference data used to optimize the coefficients of the determination function are based on internal pressure waveform data previously acquired in the sample dispensing nozzle under a normal condition and internal pressure waveform data under an abnormal condition.
5. The automatic analyzer according to claim 1 ,
wherein a number of the plurality of feature quantities is 40 or more.
6. The automatic analyzer according to claim 1 ,
wherein the processor is further programmed to:
change operation control for the reaction disk, the sample dispensing mechanism, the reagent disk, the reagent dispensing mechanism, and the spectroscopic detector in accordance with a determined type of the abnormal suction or ejection,
wherein the type of the abnormal suction or ejection includes at least one of clogging, air sucking, and bubble sucking.