Alpha-1-microglobulin for use in the protection of kidneys in radionuclide therapy
This invention relates to α 1 -microglobulin (A1M) for use in the diagnosis or treatment of malignancies requiring radionuclide diagnostics (RD), radionuclide therapy (RNT) or radioimmunotherapy (RIT), respectively, wherein A1M is used as a co-treatment to RD, RNT or RIT.
1. A method of treating impaired glomerular filtration rate (GFR) kidney injury in a subject in need thereof undergoing radionuclide diagnostics (RD), radionuclide therapy (RNT), or radioimmunotherapy (RIT) comprising administering a compound labelled with a radionuclide, wherein the compound labelled with a radionuclide is a somatostatin analogue selected from the group consisting of octreotide, lanreotide, Tyr 3 -octreotide, Tyr 3 -octreotate, DOTADOC, DODATATE, DOTA-lanreotide, pasireotide, dopastatin, and octreotide LAR, said method further comprising administering α 1 -microglobulin (A1M) to said subject, wherein the A1M has at least 95% sequence identity with SEQ ID NO: 1 or SEQ ID NO: 2.
2. The method of claim 1 , wherein the A1M is administered between 60 minutes before and 30 minutes after administration of the compound labelled with a radionuclide.
3. The method of claim 1 , wherein the A1M is administered between 30 minutes before and 30 minutes after administration of the compound labelled with a radionuclide.
4. The method of claim 1 , wherein the A1M is administered between 10 minutes before and 10 minutes after administration of the compound labelled with a radionuclide.
5. The method of claim 1 , wherein the A1M is administered simultaneously with the compound labelled with a radionuclide.
6. The method of claim 1 , wherein the A1M is administered in multiple daily doses during the first week after administration of the compound labelled with a radionuclide.
7. A kit comprising al A1M having at least 95% sequence identity with SEQ ID NO: 1 or SEQ ID NO: 2 and b) a diagnostic agent, a radionuclide therapeutic agent, or a radioimmunotherapeutic agent, said agent comprising a compound labelled with a radionuclide, wherein the compound labelled with a radionuclide is a somatostatin analogue selected from the group consisting of octreotide, lanreotide, Tyr 3 -octreotide, Tyr 3 -octreotate, DOTADOC, DODATATE, DOTA-lanreotide, pasireotide, dopastatin, and octreotide LAR.
8. The method according to claim 1 , wherein the A1M has at least 95% sequence identity with SEQ ID NO: 1.
9. The method according to claim 1 , wherein the A1M has at least 95% sequence identity with SEQ ID NO: 2.
10. The kit according to claim 7 , wherein the A1M has at least 95% sequence identity with SEQ ID NO: 1.
11. The kit according to claim 7 , wherein the A1M has at least 95% sequence identity with SEQ ID NO: 2.