Compositions and methods for treatment and prevention of pyrexia in horses
Methods for treating and preventing pyrexia and other diseases in equines such as horses involving administering an oral pharmaceutical formulation containing metamizole are disclosed.
1. A method for treating an equine with pyrexia, said method comprising orally administering a therapeutically effective dose of metamizole to said equine, wherein the dose is orally administered as a gel or paste, wherein the gel or paste comprises metamizole at a concentration of 400 mg/ml to 600 mg/ml, xanthan gum at a concentration of 5 mg/ml to 20 mg/ml, and propylene glycol at a concentration of 50 mg/ml to 200 mg/ml.
2. The method of claim 1 , wherein said dose is in the range of 25 mg metamizole per kg of equine subject weight (mg/kg) to 40 mg/kg.
3. The method of claim 1 , wherein said gel or paste comprises 500 mg/ml metamizole sodium monohydrate, 10 mg/ml xanthan gum, and 100 mg/ml propylene glycol, in an aqueous solution.
4. The method of claim 1 , wherein the equine's temperature is reduced by at least 1° C. six hours after administration of metamizole.
5. The method of claim 1 , wherein the metamizole is metamizole sodium monohydrate.
6. The method of claim 1 , wherein the gel or paste has a viscosity of 200 cps to 20,000 cps at 25° C.
7. The method of claim 1 , wherein said dose is 40 mg metamizole per kg of equine subject weight (mg/kg).
8. The method of claim 7 , wherein the concentration of metamizole in said gel or paste is 500 mg/ml.
9. The method of claim 8 , wherein a syringe is used to orally administer the gel or paste.
10. The method of claim 7 , wherein the therapeutically effective dose of metamizole is administered up to three times daily for up to five days.
11. The method of claim 1 , wherein the therapeutically effective dose of metamizole is administered up to three times daily for up to five days.
12. The method of claim 2 , wherein said dose is 40 mg metamizole per kg of equine subject weight (mg/kg).
13. The method of claim 12 , wherein a syringe is used to orally administer the gel or paste.
14. The method of claim 12 , wherein the therapeutically effective dose of metamizole is administered up to three times daily for up to five days.
15. The method of claim 2 , wherein said gel or paste comprises 500 mg/ml metamizole sodium monohydrate, 10 mg/ml xanthan gum, and 100 mg/ml propylene glycol, in an aqueous solution.
16. The method of claim 4 , wherein said gel or paste comprises 500 mg/ml metamizole sodium monohydrate, 10 mg/ml xanthan gum, and 100 mg/ml propylene glycol, in an aqueous solution.
17. The method of claim 6 , wherein said gel or paste comprises 500 mg/ml metamizole sodium monohydrate, 10 mg/ml xanthan gum, and 100 mg/ml propylene glycol, in an aqueous solution.