Method for treating obesity, diabetes, cardiovascular and kidney diseases by regulating GPR30/GPER activity
The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).
1. A method of treating or reducing the likelihood of a disease state or condition in a patient in which excessive production or formation of Nox (NADPH oxidase) isoforms leads to excessive ROS production or formation that mediates said disease state or condition comprising administering to said patient a compound which inhibits and/or reduces the production and/or formation of said Nox (NADPH oxidase) isoforms in said patient, wherein said disease state or condition is a cardiovascular disease state or condition, said cardiovascular disease state or condition is atherosclerosis, myocardial infarction, stroke, arterial hypertension, coronary artery disease, restenosis after balloon angioplasty, ischemia/reperfusion injury after myocardial or cerebral infraction, hypertrophic cardiomyopathy, heart failure or heart failure associated with aging and said compound is according to the chemical structure:
Where R is H or an isopropyl group, or
a pharmaceutically acceptable salt or mixture thereof.
2. The method according to claim 1 wherein R is an isopropyl group.
3. The method according to claim 1 wherein said compound is a pharmaceutically acceptable salt.
4. The method according to claim 1 wherein R is H.
5. The method according to claim 4 wherein said compound is a pharmaceutically acceptable salt.
6. The method according to claim 1 wherein said disease state or condition is heart failure.
7. The method according to claim 2 wherein said disease state or condition is heart failure.
8. The method according to claim 3 wherein said disease state or condition is heart failure.
9. The method according to claim 4 wherein said disease state or condition is heart failure.
10. The method according to claim 5 wherein said disease state or condition is heart failure.