Systems and methods for promoting cellular activities for tissue maintenance, repair, and regeneration
View Patent ↗Stimulating cell activity within a tissue is performed by an ultrasound array transducer having a plurality of transducer elements and a controller that actuates a plurality of transducer elements to emit focused acoustic energy to a plurality of focal zone locations in a scan direction at a focal zone scan rate. The actuation of the plurality of transducer elements to emit focused acoustic energy to the plurality of focal zone locations in the scan direction at the focal zone scan rate is repeated for a plurality of sweep cycles at a sweep rate which stimulates cells for optimal tissue growth.
1. A method of stimulating cell activity by mechanical loading of a tissue at a region of interest (ROI), the method comprising:
locating in a vicinity of the ROI an ultrasound array transducer, the ultrasound array transducer comprising a plurality of transducer elements;
actuating the plurality of transducer elements to emit focused acoustic energy at a loading rate to each focal zone of a plurality of focal zone locations in a scan direction at a focal zone scan rate; and
repeating the actuating for a plurality of sweep cycles at a predetermined sweep rate,
wherein the emitted focused acoustic energy induces pressure gradients that press on sides of cells in each focal zone of the plurality of focal zone locations, and
wherein the predetermined sweep rate is twice the loading rate.
2. The method of claim 1 , wherein the scan direction is opposite for alternate sweep cycles.
3. The method of claim 1 , wherein actuating the plurality of transducer elements to emit focused acoustic energy to the plurality of focal zone locations is performed in two spatial dimensions.
4. The method of claim 1 , wherein actuating the plurality of transducer elements to emit focused acoustic energy to the plurality of focal zone locations is performed in three spatial dimensions.
5. The method of claim 1 , wherein the focused acoustic energy has an intensity in the range of 5 mW/cm 2 to 180 mW/cm 2 at the ROI.
6. The method of claim 1 , wherein the loading rate is greater than 0.1 Hz.
7. The method of claim 1 , wherein the focal zone locations are uniformly spaced throughout the ROI.
8. The method of claim 1 , wherein performing the plurality of sweep cycles at the predetermined sweep rate is performed for a treatment duration, the treatment duration having a time range of five minutes to sixty minutes.
9. The method of claim 8 , wherein the treatment duration further comprises a rest period.
10. A system for stimulating cell activity within a body at a region of interest (ROI), the system comprising:
an ultrasound array transducer, the ultrasound array transducer comprising a plurality of transducer elements; and
a controller programmed to:
actuate the plurality of transducer elements to emit focused acoustic energy at a loading rate to each focal zone of a plurality of focal zone locations in a scan direction at a focal zone scan rate; and
repeat the actuating for a plurality of sweep cycles at a predetermined sweep rate,
wherein the emitted focused acoustic energy induces pressure gradients that press on sides of cells in each focal zone of the plurality of focal zone locations, and
wherein the predetermined sweep rate is twice the loading rate.
11. The system of claim 10 , wherein the ultrasound array transducer is in a linear format.
12. The system of claim 10 , wherein the ultrasound array transducer is in a two-dimensional matrix format.
13. The system of claim 10 , wherein the focused acoustic energy has an intensity in the range of 5 mW/cm 2 to 180 mW/cm 2 at the ROI.
14. The system of claim 10 , wherein the loading rate is greater than 0.1 Hz.
15. The system of claim 10 , wherein the focal zone locations are uniformly spaced throughout the ROI.
16. The system of claim 10 , wherein the controller is further configured to actuate, for a plurality of sweep cycles at a predetermined sweep rate, and
wherein performing the plurality of sweep cycles at the predetermined sweep rate is performed for a treatment duration, the treatment duration having a time range of five minutes to sixty minutes.
17. A controller for stimulating cell activity within a body at a region of interest (ROI), the controller programmed to:
actuate a plurality of transducer elements to emit focused acoustic energy at a loading rate to each focal zone of a plurality of focal zone locations in a scan direction at a focal zone scan rate; and
repeat the actuating for a plurality of sweep cycles at a predetermined sweep rate,
wherein the predetermined sweep rate is twice the loading rate, and
wherein the emitted focused acoustic energy induces pressure gradients that press on sides of cells in each focal zone of the plurality of focal zone locations.
18. The controller of claim 17 , wherein the loading rate is greater than 0.1 Hz.
19. The system of claim 18 , wherein the scan direction is opposite for alternate sweep cycles.