Compositions and methods to promote wound healing
The present disclosure describes compositions and methods to promote wound healing. The compositions and methods include an interleukin-1 beta (IL-1B) receptor antagonist (IL-1Ra), such as anakinra.
1. A method of promoting healing of a chronic wound in a diabetic subject comprising administering to the chronic wound a therapeutically effective amount of a gel comprising a therapeutic agent consisting of a therapeutic protein consisting of the sequence provided in SEQ ID NO: 26 (anakinra), thereby promoting healing of the chronic wound.
2. The method of claim 1 , wherein the chronic wound is a diabetic ulcer.
3. The method of claim 1 , wherein the administering is topically administering.
4. The method of claim 1 , further comprising applying a wound dressing to the wound.
5. The method of claim 4 , wherein the administering and applying are achieved in one step.
6. The method of claim 4 , wherein the wound dressing is an adhesive bandage.
7. The method of claim 1 further comprising administering a platelet-derived growth factor and/or Becaplermin.