Compositions and methods for suppressing or reducing systemic immune response in a subject
View Patent ↗The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.
1. A method of increasing systemic regulatory T cell (Treg) levels in a subject, the method comprising:
topically administering to the subject a pharmaceutically effective amount of a composition consisting essentially of a vitamin D 3 analog, wherein the vitamin D 3 analog is 26,27-cyclo-22-ene-1α,24S-dihydroxyvitamin D 3 (MC903 or calcipotriol) and at least one pharmaceutically acceptable excipient,
whereby systemic Treg levels are increased in the subject, wherein the vitamin D3 analog is the only biologically active agent administered to the subject; and
wherein the subject is afflicted with an inflammatory disease selected from the group consisting of type I diabetes, type II diabetes, atherosclerosis, multiple sclerosis, and rheumatoid arthritis.
2. The method of claim 1 , wherein the composition is administered topically to the subject in a dosing schedule wherein a treatment week is followed by a no-treatment week.
3. The method of claim 2 , wherein, in the treatment week, the subject is topically administered the composition at a frequency selected from the group consisting of: every day and every other day.
4. The method of claim 1 , wherein the composition is applied to a given skin area of the subject, such that about 0.2 nmol to about 20 nmol analog per cm 2 of given skin are administered to the subject.
5. The method of claim 4 , wherein the given skin area in the subject ranges from about 100 cm 2 to 2,500 cm 2 .
6. The method of claim 1 , wherein the composition has between about 0.005% and about 10% (w/w) of the analog.
7. A method of suppressing or reducing systemic immune response in a subject, the method comprising:
topically administering to the subject a pharmaceutically effective amount of a composition consisting essentially of a vitamin D 3 analog and at least one pharmaceutically acceptable excipient, wherein the vitamin D 3 analog is 26,27-cyclo-22-ene-1α,24S-dihydroxyvitamin D 3 (MC903 or calcipotriol),
whereby the systemic immune response in the subject is suppressed or reduced, wherein the vitamin D3 analog is the only biologically active agent administered to the subject; and
wherein the subject is afflicted with an inflammatory disease selected from the group consisting of type I diabetes, type II diabetes, atherosclerosis, multiple sclerosis, and rheumatoid arthritis.
8. The method of claim 7 , wherein the composition is administered topically to the subject in a dosing schedule wherein a treatment week is followed by a no-treatment week.
9. The method of claim 8 , wherein, in the treatment week, the subject is topically administered the composition at a frequency selected from the group consisting of: every day, and every other day.
10. The method of claim 7 , wherein the composition is applied to a given skin area of the subject, such that about 0.2 nmol to about 20 nmol analog per cm 2 of given skin are administered to the subject.
11. The method of claim 10 , wherein the given skin area of the subject ranges from about 100 cm 2 to 2,500 cm 2 .
12. A method of treating a systemic inflammatory disease or disorder in a subject, the method comprising:
topically administering to the subject in need thereof a pharmaceutically effective amount of a composition consisting essentially of a vitamin D 3 analog and at least one pharmaceutically acceptable excipient, wherein the vitamin D 3 analog is 26,27-cyclo-22-ene-1α,24S-dihydroxyvitamin D 3 (MC903 or calcipotriol), wherein the vitamin D3 analog is the only biologically active agent administered to the subject; and
wherein the disease or disorder is selected from the group consisting of type I diabetes, type II diabetes, atherosclerosis, multiple sclerosis, and rheumatoid arthritis.
13. The method of claim 12 , wherein the composition is administered topically to the subject in a dosing schedule wherein a treatment week is followed by a no-treatment week.
14. The method of claim 13 , wherein, in the treatment week, the subject is topically administered the composition at a frequency selected from the group consisting of: every day, and every other day.
15. The method of claim 12 , wherein the composition is applied to a given skin area of the subject, such that about 0.2 nmol to about 20 nmol analog per cm 2 of given skin are administered to the subject.
16. The method of claim 15 , wherein the given skin area of the subject ranges from about 100 cm 2 to 2,500 cm 2 .