Tool for recommendation of ventilation therapy guided by risk score for acute respirator distress syndrome (ARDS)
Disclosed herein are approaches for monitoring a patient in real-time for ARDS development and providing a biomarker-driven ventilation therapy recommendation tool based on the correlation of various therapy patterns and an ARDS biomarker score. When the ARDS biomarker indicates that a patient has a high ARDS risk, the recommendation tool suggests possible therapy routes based on clinical practice. In response to a high score output by the ARDS detection model, the tool outputs a recommendation to initiate a lung protective ventilation strategy (Low Tidal Volume, high Positive End-Expiratory Pressure (PEEP)). A high ARDS score is recognized to be predictive of the appropriateness of such therapy up to several hours before such intervention is typically initiated under current clinical practices.
1. A therapy guidance tool for acute respiratory distress syndrome intensive care settings comprising:
a display device; and
a processor configured to:
compute an Acute Respiratory Distress Syndrome (ARDS) score indicative of whether a patient has ARDS based on measured physiological variables of the patient;
generate a recommended ventilation strategy for the patient using a threshold based on ARDS score history, wherein the threshold is chosen to optimally separate median ARDS score values for protective strategy from median ARDS score values for traditional strategy and the recommended ventilation strategy is either a traditional ventilation strategy or a protective ventilation strategy; and
display a representation of the ventilation therapy recommendation on the display device.
2. The therapy guidance tool according to claim 1 , wherein the ARDS score is computed by:
receiving values of a plurality of physiological variables for the patient;
computing the ARDS score based at least on the received values of the plurality of physiological variables for the patient; and
displaying a representation of the computed ARDS score on the display device.
3. The therapy guidance tool of claim 1 , wherein the traditional ventilation strategy includes a recommended tidal volume of between 10 ml/kg and 15 ml/kg inclusive and the protective ventilation strategy includes a recommended tidal volume of between 4 ml/kg and 8 ml/kg inclusive.
4. The therapy guidance tool of claim 3 , wherein the traditional ventilation strategy includes a recommended positive end-expiratory pressure (PEEP) of between 5 cm H 2 O and 12 cm H 2 O inclusive and the protective ventilation strategy includes a recommended PEEP of greater than 12 cm H 2 O.
5. The therapy guidance tool of claim 4 , wherein the processor is further configured to display the representation of the ventilation therapy recommendation on the display device with an indication of a time horizon for the ventilation therapy recommendation wherein the indicated time horizon is two hours or less.
6. The therapy guidance tool of claim 1 , wherein the ARDS score is in a range [ 0 , 1 ] or a percentage in the range [0%, 100%] and the threshold is 0.8 or 80%.
7. The therapy guidance tool of claim 1 , wherein the processor is further configured to compute the ARDS score continuously in real time.
8. The therapy guidance tool of claim 1 , wherein the measured physiological variables of the patient include at least heart rate, respiration rate, and a blood pressure.
9. The therapy guidance tool of claim 1 , wherein the processor is configured to display the representation of the recommendation of a ventilation strategy for the patient on the display device using a graphical user interface (GUI).
10. A method for treating a patient comprising:
monitoring physiological variables of the patient;
using a processor:
computing an Acute Respiratory Distress Syndrome (ARDS) score for the patient based on the monitored physiological variables, and
generating a mechanical ventilation recommendation for the patient using a threshold based on ARDS score history after the ARDS score is above the threshold, wherein the threshold is chosen to optimally separate median ARDS score values for protective strategy from median ARDS score values for traditional strategy; and
displaying the mechanical ventilation recommendation for the patient on a display device.
11. The method of claim 10 , wherein the monitored physiological variables include a heart rate, a respiration rate, and a blood pressure.
12. The method of claim 10 , wherein the traditional ventilation settings include tidal volume between 10 ml/kg and 15 ml/kg inclusive and the protective ventilation settings include tidal volume between 4 ml/kg and 8 ml/kg inclusive.
13. The method of claim 10 , wherein the protective ventilation settings include a Positive End-Expiratory Pressure (PEEP) of greater than 12 cm H 2 O.
14. The method of claim 10 , wherein the ARDS score is in a range [ 0 , 1 ] or a percentage in the range [0%, 100%] and the threshold is 0.8 or 80%.
15. The method of claim 10 , further comprising:
displaying past, current, and future trajectories of the ARDS score.