Methods of diagnosing post-operative complications using serum nitric oxide levels
Disclosed herein are methods of using serum nitric oxide levels to diagnose subjects as having or likely to develop a post-operative complication.
1. A method of treating a subject after having had an operation, which comprises administering to the subject a pharmacologic agent known to treat atrial fibrillation and/or subjecting the subject to atrial pacing protocols where, at 24 hours postop, the subject exhibits a negative change in serum nitrogen oxide concentration that is at least about 28% more than the average percent decrease exhibited by normal control subjects.
2. The method according to claim 1 , which further comprises optimizing the fluid status and correcting fluid volume deficits in the subject to maintain a mean blood pressure of greater than 65 mmHg and central venous pressure of greater than 8-12 mmHg in the subject and/or reducing dosages of nephrotoxic medications administered to the subject where, at 24 hours postop, the subject exhibits a negative change in serum nitrogen oxide concentration that is about 64-67% more than the average percent decrease exhibited by normal control subjects.
3. The method according to claim 1 , wherein the percent decrease is about 28-58% more than the average percent decrease exhibited by normal control subjects.
4. The method according to claim 1 , wherein the subject is treated before atrial fibrillation occurs.
5. The method according to claim 2 , wherein the subject is treated before acute kidney injury occurs.
6. The method according to claim 1 , wherein the operation is cardiac surgery.
7. The method according to claim 1 , wherein the operation is cardiac surgery with cardiopulmonary bypass.
8. A method of treating a subject after having had an operation, which comprises administering to the subject a pharmacologic agent known to treat atrial fibrillation and/or subjecting the subject to atrial pacing protocols where, at 24 hours postop, the subject exhibits at least about a 40% decrease in serum nitric oxide concentration.
9. The method according to claim 8 , wherein the percent decrease is about 28-58% more than the average percent decrease exhibited by normal control subjects.
10. The method according to claim 8 , wherein the subject is treated before atrial fibrillation occurs.
11. The method according to claim 8 , wherein the operation is cardiac surgery.
12. The method according to claim 8 , wherein the operation is cardiac surgery with cardiopulmonary bypass.
13. A method of treating a subject after having had an operation, which comprises optimizing the fluid status and correcting fluid volume deficits in the subject to maintain a mean blood pressure of greater than 65 mmHg and central venous pressure of greater than 8-12 mmHg in the subject and/or reducing dosages of nephrotoxic medications administered to the subject where, at 24 hours postop, the subject exhibits (a) a negative change in serum nitrogen oxide concentration that is about 64-67% more than the average percent decrease exhibited by normal control subjects, or (b) about a 55-60% decrease in serum nitric oxide concentration.
14. The method according to claim 13 , wherein the subject is treated before acute kidney injury occurs.
15. The method according to claim 13 , wherein the operation is cardiac surgery.
16. The method according to claim 13 , wherein the operation is cardiac surgery with cardiopulmonary bypass.