IP Library › Granted Patent US 10,214,574
Granted Patent B2
US 10,214,574 · App. 15/564,858 · Granted Feb 26, 2019

Engineered calmodulin for treatment of ryanopathies

Inventors: Jonathan Paul Davis (Westerville, OH); Sandor Gyorke (Dublin, OH)
Assignee: Ohio State Innovation Foundation
C07K14/4728A61K38/1738A61K38/00C12N15/861C12N2750/14143
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Quick Facts
Patent No.
US 10,214,574
App. No.
15/564,858
Granted
Feb 26, 2019
Kind
B2
Abstract

Compositions and methods are disclosed for altering the binding affinity of calmodulin for ryanodine receptor 2 (RyR2). As disclosed herein, these therapeutic calmodulin (TCaM) proteins can be used to correct ryanopathies by prolonging the RyR2 refractory period. Therefore, also disclosed is a method for treating a ryanopathy-associated disease in a subject that involves administering to the subject a composition comprising a TCaM disclosed herein.

Claims (4)

1. An isolated polypeptide comprising the amino acid sequence SEQ ID NO:1 having at least one mutation selected from the group consisting of F13Q, T27D, T29D, M37Q, L40Q, N61D, M72Q, and M73Q.

2. The isolated polypeptide of claim 1 , wherein the polypeptide has the amino acid sequence SEQ ID NO:2.

3. The isolated polypeptide of claim 1 , wherein the polypeptide is cyclized.

4. The isolated polypeptide of claim 1 , further comprising an N-terminal glutathione.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 5, 2018
From: OHIO STATE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 046498/0934 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 27, 2017
From: DAVIS, JONATHAN PAUL; GYORKE, SANDOR
To: OHIO STATE INNOVATION FOUNDATION
Reel/Frame 044491/0020 →
Continuity (2)
Provisional Application 62147903 · Apr 15, 2015
Related Publication 20180086803A1 · Mar 29, 2018