Pharmaceutical salt forms of an inhibitor of semicarbazide-sensitive amine oxidase (SSAO)
The mesylate and sulphate salts of (3S)-Tetrahydrofuran-3-yl (4S)-4-isopropyl-,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate mesylate, and hydrates thereof, and their use in medicine.
1. A compound selected from:
(3 S)-Tetrahydrofuran-3-yl (4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate mesylate having a melting point of 189° C., and
(3 S)-Tetrahydrofuran-3-yl (4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate sulfate 1.5H 2 O having a melting point of 106° C.
2. A pharmaceutical composition comprising:
the compound according to claim 1 , and
one or more suitable excipients.
3. The compound according to claim 1 , which is (3 S)-Tetrahydrofuran-3-yl (4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate mesylate having a melting point of 189° C.
4. The compound according to claim 3 having a purity of greater than 99.5%.
5. The compound according to claim 3 having an enantiomeric purity of greater than 99.5%.
6. The compound according to claim 1 , which is (3 S)-Tetrahydrofuran-3-yl (4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate sulfate 1.5H 2 O having a melting point of 106° C.
7. The compound according to claim 6 having a purity of greater than 99.3%.
8. The compound according to claim 6 having an enantiomeric purity of greater than 99.3%.