Antibacterial compounds and methods of making and using same
The invention provides novel antibacterial diamide compounds, pharmaceutical compositions comprising the compounds and methods for treating or preventing an infection in a subject using the compounds.
1. A compound or a salt or solvate thereof,
wherein the compound is selected from the group consisting of:
2. The compound of claim 1 , which is selected from the group consisting of fgkc, fgkb, rgba, fgoa, fgka, fgna, fgbb, fgqa and fgbc.
3. The compound of claim 2 , wherein the compound is fgkc, fgkb, rgba, fgoa, fgka or fgna.
4. The compound of claim 2 , wherein the compound is fgkc, fgbb, or fgbc.
5. The compound of claim 2 , wherein the compound is fgba or fgqa.
6. The compound of claim 2 , wherein the compound is fgna.
7. A method of inhibiting a N-acetylglucosaminidase in a cell, the method comprising contacting the cell with a compound of claim 1 .
8. A method of inhibiting an N-acetylglucosaminidase in the cytosol of a cell, the method comprising contacting the N-acetylglucosaminidase with a compound of claim 1 .