Anti-cancer compounds
This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.
1. A compound, or a salt or a hydrate or a solvate thereof, having a structure according to formula (I):
wherein Z is —O— or —CH 2 — or —NH— or —N(CH 2 R 5 )— wherein R 5 is hydrogen or substituted or unsubstituted C 1 or C 2 or C 3 or C 4 or C 5 or C 6 or C 7 or C 8 or C 9 or C 10 alkyl; R 1 is hydrogen or substituted or unsubstituted C 1 or C 2 or C 3 or C 4 or C 5 or C 6 or C 7 or C 8 or C 9 or C 10 alkyl or substituted or unsubstituted C 1 or C 2 or C 3 or C 4 or C 5 or C 6 or C 7 or C 8 or C 9 or C 10 heteroalkyl or substituted or unsubstituted C 3 or C 4 or C 5 or C 6 cycloalkyl or unsubstituted phenyl or substituted or unsubstituted piperidinyl or substituted or unsubstituted azetidinyl; R 2 is hydrogen or methyl or ethyl or propyl or isopropyl or halogen; R 3 is hydrogen or fluoro or chloro or methyl or ethyl or propyl or isopropyl; R 4 is hydrogen or fluoro or chloro or methyl or ethyl or propyl or isopropyl with the proviso that the compound is not according to formula (XV):
wherein R 1 is methyl or ethyl or unsubstituted C 3 alkyl.
2. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 2 is H; R 3 is H; and R 4 is H.
3. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein Z is O.
4. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is methyl.
5. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is ethyl.
6. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is C 1 or C 2 or C 3 or C 4 or C 5 or C 6 or C 7 or C 8 or C 9 or C 10 alkyl, substituted with unsubstituted C 1 or C 2 or C 3 or C 4 or C 5 or C 6 alkoxy.
7. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is C 2 alkyl, substituted with methoxy.
8. A pharmaceutical formulation comprising:
a) the compound, or a salt or a hydrate or a solvate thereof, of claim 1 ; and claim; and
b) a pharmaceutically acceptable excipient.
9. The pharmaceutical formulation of claim 8 , wherein the pharmaceutical formulation is a unit dosage form.
10. The pharmaceutical formulation of claim 8 wherein the salt of the compound of is a pharmaceutically acceptable salt.
11. A method of inhibiting PARP1 and/or ABL1 and/or ABL2 and/or tubulin, comprising: contacting said PARP1 and/or ABL1 and/or ABL2 and/or tubulin with an effective amount of the compound of claim 1 , thereby inhibiting said PARP1 and/or ABL1 and/or ABL2 and/or tubulin.
12. A method of treating cancer in an animal, comprising: administering to an animal suffering from said cancer a therapeutically effective amount of the compound of claim 1 , wherein said cancer is multiple myeloma, lung cancer, ovarian cancer, pancreatic cancer, breast cancer, or mesothelioma, thereby treating the cancer.
13. The method of claim 12 , wherein the cancer is multiple myeloma.
14. The method of claim 12 , wherein the animal is a human.
15. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein Z is —NH—.
16. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 2 is methyl.
17. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 2 is halogen.
18. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 2 is chlorine.
19. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein
R 3 is fluorine and R 4 is fluorine; or
R 3 is chlorine and R 4 is chlorine.
20. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, having a structure according to formula (II):
21. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, having a structure according to formula (III):
22. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, having a structure according to formula (IV):
23. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, having a structure according to formula (V):
24. The compound of claim 23 , or a salt or a hydrate or a solvate thereof, wherein R 2 is methyl or halogen.
25. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, having a structure according to formula (XIII):
26. The compound of claim 25 , or a salt or a hydrate or a solvate thereof, wherein R 2 is methyl or halogen.
27. The compound of claim 25 , or a salt or a hydrate or a solvate thereof, wherein
R 3 is fluorine and R 4 is fluorine; or
R 3 is chlorine and R 4 is chlorine.
28. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, having a structure according to formula (XIV):
29. The compound of claim 28 , or a salt or a hydrate or a solvate thereof, wherein
R 3 is fluorine and R 4 is fluorine; or
R 3 is chlorine and R 4 is chlorine.
30. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, which is 2-methoxyethyl (5-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-b enzimidazol-2-yl)carbamate or ethyl (5-(6,7-difluoro-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)carbamate or 2-methoxyethyl (5-(6,7-difluoro-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)carbamate or ethyl (5-(6,7-dichloro-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)carbamate or 2-methoxyethyl (5-(6,7-dichloro-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)carbamate or 1-ethyl-3-(5-(4-oxo-3,4-dihydrophthalazin-l-yl)-1H-benzimidazol-2-yl)urea or 1-cyclopropyl-3-(5-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)urea or ethyl (7-methyl-5-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)carbamate or ethyl (5-(6,7-difluoro-4-oxo-3,4-dihydrophthalazin-1-yl)-7-methyl-1H-benzimidazol-2-yl)carbamate or ethyl (7-chloro-5-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)carbamate or 2-methoxyethyl (7-chloro-5-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)carbamate or 1-ethyl-3-(7-chloro-5-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)urea or 2-methoxyethyl(7-methyl-5-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)carbamate or 1-ethyl-3-(7-methyl-5-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-benzimidazol-2-yl)urea.
31. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is substituted or unsubstituted C 3 or C 4 cycloalkyl.
32. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is substituted or unsubstituted C 1 or C 2 or C 3 alkyl.
33. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is C 1 or C 2 or C 3 alkyl, substituted with unsubstituted C 1 or C 2 or C 3 alkoxy.
34. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is C 1 or C 2 or C 3 , substituted with unsubstituted dimethylamino.
35. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is C 1 or C 2 or C 3 or C 4 or C 5 alkyl, substituted with fluorine.
36. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is C 1 or C 2 or C 3 or C 4 or C 5 alkyl, substituted with one fluorine.
37. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is C 1 or C 2 or C 3 or C 4 or C 5 alkyl, substituted with two fluorines.
38. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is C 1 or C 2 or C 3 or C 4 or C 5 alkyl, substituted with three fluorines.
39. The compound of claim 1 , or a salt or a hydrate or a solvate thereof, wherein R 1 is C 1 or C 2 alkyl, substituted with three fluorines.