Manipulator device and therapeutic and diagnostic methods
Dexterous manipulation devices are provided having an end effector enabling large curvature with a diameter of 1 mm or less that can articulate about an axis in a working space of about or less than 4 mm by 4 mm. Preferred devices are robotically actuated and controlled and can be used for a variety of therapeutic and diagnostic applications.
1. A dexterous manipulation device comprising:
an end effector that:
1) has a cross-section of from 0.4 mm to 1 mm;
2) can articulate in a working space less than 4 mm by 4 mm;
3) has greater than 90-degrees of rotation with two degrees of freedom; and
4) includes disc elements each having concave top and bottom surfaces,
wherein the disc elements are stacked alternating in orthogonal directions with the concave top and bottom surfaces of adjacent disc elements forming a rolling joint,
wherein each disc element is a solid disc having a plurality of apertures formed therethrough, and
wherein the plurality of apertures includes a center aperture and a plurality of surrounding apertures, each of the plurality of apertures having a substantially similar diameter.
2. The device of claim 1 wherein the device is robotically controlled.
3. The device of claim 1 wherein the device is manually controlled.
4. The device of claim 1 wherein the end effector is less than 0.9 mm in diameter.
5. The device of claim 1 wherein the end effector is less than 3 mm in length.
6. The device of claim 1 wherein the end effector has a cross-section of 0.5 mm or greater.
7. The device of claim 1 wherein the end effector has a cross-section of 0.6 mm or greater.
8. The device of claim 1 further comprising an actuation unit.
9. The device of claim 8 wherein the actuation unit comprises a housing, a motion scaling system, a motor disposed within the actuation unit and the actuation unit comprises a plurality of pulleys.
10. The device of claim 1 further comprising a body unit mated with an actuation unit.
11. The device of claim 10 wherein a plurality of actuation wires extends along the body unit.
12. The device of claim 1 wherein the end effector comprises a needle tip.
13. The device of claim 1 wherein the end effector comprises forceps.
14. The device of claim 1 wherein the end effector comprises a pipette.
15. The device of claim 1 wherein the device is an intra-ocular device.
16. A method for treating a subject comprising:
contacting tissue of the subject with the device of claim 1 .
17. A surgical system comprising an actuation unit; a cylindrical body unit; and an end effector that 1) has a cross-section of 0.4 to 1 mm; 2) can articulate in a working space less than 4 mm by 4 mm; and 3) has greater than 90-degrees of rotation with two degrees of freedom, wherein the end effector further comprises a plurality of connected disc elements to provide at least two degrees of rotational freedom, wherein the disc elements are stacked and assembled alternating in orthogonal directions and concave top and bottom surfaces of adjacent disc elements form a rolling joint, wherein each disc element is a solid disc having a plurality of apertures formed therethrough, and wherein the plurality of apertures includes a center aperture and a plurality of surrounding apertures, each of the plurality of apertures having a substantially similar diameter.
18. The surgical system of claim 17 wherein the actuation unit comprises 1) one or more motors and 2) a motor scaling transmission.
19. The surgical system of claim 17 wherein the body unit comprises a cabling system having a plurality of actuation wires to connect with a motor scaling transmission.
20. A device, comprising:
an actuation unit that includes a proximal portion and a distal portion;
a cylindrical body that includes a proximal end and a distal end; and
an end effector having a proximal end and a distal end,
wherein the proximal end of the cylindrical body is configured to connect to the distal portion of the actuation unit and the distal end of the cylindrical body is configured to be coupled to the proximal end of the end effector, wherein the end effector is configured to articulate about an axis in a working space less than 3 mm by 3 mm,
wherein the end effector includes disc elements each having concave top and bottom surfaces, wherein the disc elements are stacked alternating in orthogonal directions with the concave top and bottom surfaces of adjacent disc elements forming a rolling joint,
wherein each disc element is a solid disc having a plurality of apertures formed therethrough, and
wherein the plurality of apertures includes a center aperture and a plurality of surrounding apertures, each of the plurality of apertures having a substantially similar diameter.
21. The device of claim 20 , wherein the size of the end effector is less than 0.9 mm in diameter.
22. A surgical system comprising:
an actuation unit that includes a proximal portion and a distal portion having a housing;
an elongated cylindrical body having a hollow inner lumen that extends from a proximal end and a distal end of the elongated cylindrical body; and
an end effector having a proximal end and a distal end wherein the distal end has a diameter of less than 1 mm and a length of less than 3 mm configured to articulate in a working space less than 3 mm by 3 mm,
wherein the proximal end of the cylindrical body is configured to connect to the distal portion of the actuation unit and the distal end of the cylindrical body is configured to be coupled to the proximal end of the end effector,
wherein the end effector includes disc elements each having concave top and bottom surfaces, wherein the disc elements are stacked alternating in orthogonal directions with the concave top and bottom surfaces of adjacent disc elements forming a rolling joint,
wherein each disc element is a solid disc having a plurality of apertures formed therethrough, and
wherein the plurality of apertures includes a center aperture and a plurality of surrounding apertures, each of the plurality of apertures having a substantially similar diameter.
23. The surgical system of claim 22 , wherein the actuation unit having a housing includes,
a plurality of motors disposed within the housing;
a motor scaling transmission disposed within the housing configured to individually control a lever mechanism; and
a plurality of pulley guides configured to route a cabling system within the housing.