Dihydropyrazolopyrimidinone compounds as PDE2 inhibitors
The present invention is directed to dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
1. A compound of structural formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R 1 represents OH, OC 1-6 alkyl, NR 2 , said alkyl optionally substituted with 1 to 3 groups of R a ,
R represents hydrogen, or C 1-6 alkyl, or two R groups can be combined with the nitrogen to which they are attached to form a C 3-6 heterocycloalkyl, said alkyl and heterocycloalkyl optionally substituted with 1 to 3 groups of halogen, or C 1-6 alkyl;
R 2 represents halo, C 1-6 alkyl, (CH 2 ) n OR, C 1-4 haloalkyl, C(O)OR, (CH 2 ) n C 4-10 heterocyclyl, O—(CH 2 ) n C 4-10 heterocyclyl, C(O)NH(CH 2 CF 3 ), C(O)NR 2 , NR 2 , NHSO 2 R, C(O)R, C(O)—N-linked morpholinyl, NHC(O)CH 3 , (CH 2 ) n C(CF 3 )OH, CH(CH 3 )CH 2 OH, CF 2 CH 2 OH, said alkyl and heterocyclyl optionally substituted with 1 to 3 groups of R a ,
R 3 and R 3a independently represent hydrogen, C 1-6 alkyl, C 2-6 alkenyl, or C 3-6 cycloalkyl, or R 3 and R 3a can combine with the carbon atom to which they are attached to form a C 3-6 cycloalkyl, said alkyl and cycloalkyl optionally substituted with 1 to 3 groups of R a ,
R a is selected from the group consisting of halo, CN, C 1-6 alkyl, (CH 2 ) n OR, (CH 2 ) n C 1-4 haloalkyl, O—C 1-4 haloalkyl, SCF 3 , SF 5 , C 6-10 aryl, —O(CH 2 ) n N(R) 2 , (CHR) n N(R) 2 , NHC(O)CH 3 , OCH 2 C 6-10 aryl, and C 3-6 cycloalkyl, said cycloalkyl optionally substituted with 1 to 3 groups of C 1-6 alkyl and C 1-4 haloalkyl;
n represents 0, 1, 2, 3, or 4.
2. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein R 1 is OH.
3. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein R 1 is NR 2 selected from the group consisting of N(CH 3 ) 2 , NH 2 , and NHCH 3 .
4. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein R 1 is OC 1-6 alkyl.
5. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein R 2 is optionally substituted C 1-6 alkyl selected from CH 2 OH, CH 2 CH 2 OH, CH 2 F, CH 3 , CF 3 , CH 2 CF 3 , CHF 2 , CH 2 CN, (CH 2 ) 2 F, CH 2 OCH 2 phenyl, CH 2 OCH 3 , CF 2 CF 3 , and CH(CH 3 )CH 2 OH.
6. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein R 3 and R 3a independently represent hydrogen, CH 3 , CH(CH 3 ) 2 , CH 2 CH 3 , C(CH 3 ) 3 , CH 2 CF 3 , cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.
7. The compound according to claim 6 or a pharmaceutically acceptable salt thereof wherein one of R 3 and R 3a is hydrogen and the other is selected from the group consisting of CH 3 , CH(CH 3 ) 2 , CH 2 CH 3 , C(CH 3 ) 3 , CH 2 CF 3 , cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.
8. The compound according to claim 1 wherein R 3 and R 3a combine with the carbon atom to which they are attached to form an optionally substituted C 3-6 cycloalkyl selected from cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.
9. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein R a is selected from OH, halo, (CH 2 ) n CH 3 , CH(CH 3 ) 2 , C(CH 3 ) 3 , (CH 2 ) n OCH 3 , OCH(CH 3 ) 2 , CF 2 CH 3 , CH 2 F, CHF 2 , (CH 2 ) n CF 3 , CF 2 CH 3 , OCHF 2 , OCF 3 , SCF 3 , SF 5 , CH 2 NH 2 , (CH 2 ) n N(CH 3 ) 2 , CF 2 CF 3 , cyclobutyl, cyclopropyl, phenyl, naphthyl, said groups where appropriate, optionally substituted with one to three groups of R b .
10. The compound according to claim 1 represented by structural formula Ia:
or a pharmaceutically acceptable salt thereof.
11. The compound according to claim 10 or a pharmaceutically acceptable salt thereof wherein R 2 is optionally substituted C 1-6 alkyl selected from CH 2 OH, CH 2 CH 2 OH, CH 2 F, CH 3 , CF 3 , CH 2 CF 3 , CHF 2 , CH 2 CN, (CH 2 ) 2 F, CH 2 OCH 2 phenyl, CH 2 OCH 3 , CF 2 CF 3 , and CH(CH 3 )CH 2 OH, R 3 and R 3a independently represent hydrogen, CH 3 , CH(CH 3 ) 2 , CH 2 CH 3 , C(CH 3 ) 3 , CH 2 CF 3 , cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, or R 3 and R 3a combine with the carbon atom to which they are attached to form an optionally substituted C 3-6 cycloalkyl selected from cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.
12. The compound according to claim 10 or a pharmaceutically acceptable salt thereof wherein R a on the phenyl ring of formula Ia is selected from chlorine, fluorine, CH 3 , CH(CH 3 ) 2 , C(CH 3 ) 3 , (CH 2 ) n OCH 3 , OCH(CH 3 ) 2 , CF 2 CH 3 , CF 2 CF 3 , CH 2 F, CHF 2 , CF 3 , OCHF 2 , OCF 3 , SF 5 , and cyclopropyl.
13. The compound according to claim 10 or a pharmaceutically acceptable salt thereof wherein R 2 is CH 2 OH, CH 2 CH 2 OH, CH 2 F, CHF 2 , CF 3 , or CH 3 , one of R 3 and R 3a is hydrogen and the other is selected from the group consisting of CH 3 , CH(CH 3 ) 2 , CH 2 CH 3 , C(CH 3 ) 3 , CH 2 CF 3 , and cyclopropyl, or R 3 and R 3a combine with the carbon atom to which they are attached to form an optionally substituted C 3-6 cycloalkyl selected from cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, and the R a on the phenyl ring of formula Ia is selected from fluorine, CH 3 , CH(CH 3 ) 2 , C(CH 3 ) 3 , (CH 2 ) n OCH 3 , OC(CH 3 ) 2 , CH(CH 3 )F 2 , CF 2 CF 3 , CH 2 F, CHF 2 , CF 3 , OCHF 2 , OCF 3 , SF 5 , and cyclopropyl.
14. The compound according to claim 1 represented by structural formula Ib:
or a pharmaceutically acceptable salt thereof.
15. The compound according to claim 14 or a pharmaceutically acceptable salt thereof wherein R 2 is optionally substituted C 1-6 alkyl selected from CH 2 OH, CH 2 CH 2 OH, CH 2 F, CH 3 , CF 3 , CH 2 CF 3 , CHF 2 , CH 2 CN, (CH 2 ) 2 F, CH 2 OCH 2 phenyl, CH 2 OCH 3 , CF 2 CF 3 , and CH(CH 3 )CH 2 OH, R 3 and R 3a independently represent hydrogen, CH 3 , CH(CH 3 ) 2 , CH 2 CH 3 , C(CH 3 ) 3 , CH 2 CF 3 , cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, or R 3 and R 3a combine with the carbon atom to which they are attached to form an optionally substituted C 3-6 cycloalkyl selected from cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.
16. The compound according to claim 14 or a pharmaceutically acceptable salt thereof wherein the R a on the phenyl ring of formula Ib is selected from chlorine, fluorine, CH 3 , CH(CH 3 ) 2 , C(CH 3 ) 3 , (CH 2 ) n OCH 3 , OC(CH 3 ) 2 , CH(CH 3 )F 2 , CF 2 CF 3 , CH 2 F, CHF 2 , CF 3 , OCHF 2 , OCF 3 , SF 5 , and cyclopropyl.
17. The compound according to claim 14 or a pharmaceutically acceptable salt thereof wherein R 2 is CH 2 OH, CH 2 CH 2 OH, CH 2 F, CHF 2 , CF 3 , or CH 3 , one of R 3 and R 3a is hydrogen and the other is selected from the group consisting of CH 3 , CH(CH 3 ) 2 , CH 2 CH 3 , C(CH 3 ) 3 , CH 2 CF 3 , and cyclopropyl, or R 3 and R 3a combine with the carbon atom to which they are attached to form an optionally substituted C 3-6 cycloalkyl selected from cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, and the R a on the phenyl ring of formula Ib is selected from fluorine, CH 3 , CH(CH 3 ) 2 , C(CH 3 ) 3 , (CH 2 ) n OCH 3 , OC(CH 3 ) 2 , CH(CH 3 )F 2 , CF 2 CF 3 , CH 2 F, CHF 2 , CF 3 , OCHF 2 , OCF 3 , SF 5 , and cyclopropyl.
18. The compound according to claim 1 which is selected from the group consisting of:
(R)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-3-(hydroxymethyl)-1-((1-methylcyclopropyl)(4-(trifluoromethyl)-phenyl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-3-(hydroxymethyl)-1-((1-methylcyclopropyl)(4-(trifluoromethyl)-phenyl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Hydroxy-3-(hydroxymethyl)-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
1-(1-(4-Cyclopropylphenyl)ethyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
1-(1-(4-tert-Butylphenyl)ethyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Hydroxy-3-(hydroxymethyl)-1-(1-p-tolylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Hydroxy-3-(hydroxymethyl)-1-[4-(trifluoromethyl)benzyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-(1-(3-Fluoro-4-(trifluoromethoxy-)phenyl)ethyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-(1-(3-Fluoro-4-(trifluoromethoxy)-phenyl)ethyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-3-(hydroxymethyl)-1-(2-methyl-1-(4-(trifluoro-methyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-3-(hydroxymethyl)-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-((3-Fluoro-4-(trifluoromethyl)phenyl)(1-methylcyclopropyl)methyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-((3-Fluoro-4-(trifluoromethyl)phenyl)(1-methylcyclopropyl)methyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-3-(hydroxymethyl)-1-{1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-6-Hydroxy-3-(hydroxymethyl)-1-{1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-6-Hydroxy-3-(hydroxymethyl)-1-{1-[4-(pentafluorosulfanyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-6-Hydroxy-3-(hydroxymethyl)-1-{1-[4-(pentafluorosulfanyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-6-Hydroxy-3-(hydroxymethyl)-1-(3,3,3-trifluoro-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-3-(hydroxymethyl)-1-(3,3,3-trifluoro-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2,2-dimethylpropyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2,2-dimethylpropyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Hydroxy-3-(hydroxymethyl)-1-(1-(4-(trifluoromethyl)phenyl)cyclobutyl)-1H-pyrazolo[3,4-d] pyrimidin-4(5H)-one,
(R)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(2,2-Dimethyl-1-(4-(trifluoromethyl)phenyl)propyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(2,2-Dimethyl-1-(4-(trifluoromethyl)phenyl)propyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-3-(hydroxymethyl)-1-(1-(4-(perfluoroethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-3-(hydroxymethyl)-1-(1-(4-(perfluoroethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
1-(2-Fluoro-1-(4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-3-(hydroxymethyl)-1H-pyrazolo[3,4-d] pyrimidin-4(5H)-one,
(R)-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)ethyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)ethyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
3-(Fluoromethyl)-6-hydroxy-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
3-(Fluoromethyl)-6-hydroxy-1-(1-p-tolylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
1-(1-(3-Fluoro-4-(trifluoromethoxy)phenyl)ethyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
3-(Fluoromethyl)-6-hydroxy-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
3-(Fluoromethyl)-6-hydroxy-1-{1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-3-(Fluoromethyl)-6-hydroxy-1-(2-methyl-1-(4-(trifluoromethoxy)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(Fluoromethyl)-6-hydroxy-1-(2-methyl-1-(4-(trifluoromethoxy)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethoxy)phenyl)methyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethoxy)phenyl)methyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
3-(Fluoromethyl)-6-hydroxy-1-(1-(4-(trifluoromethyl)phenyl)cyclobutyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-tert-Butylphenyl)ethyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethyl)phenyl)methyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-tert-Butylphenyl)-2-methylpropyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(Fluoromethyl)-6-hydroxy-1-(1-(4-(pentafluorothio)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(2,2-Dimethyl-1-(4-(trifluoromethyl)phenyl)propyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(2,2-Dimethyl-1-(4-(trifluoromethyl)phenyl)propyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methylpropyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methylpropyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-3-(fluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
3-(Chloromethyl)-6-hydroxy-1-(1-p-tolylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Hydroxy-3-methyl-1-{1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
6-Methoxy-3-methyl-1-{1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
6-Hydroxy-3-methyl-1-{1-[4-(trifluoromethoxy)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
6-Hydroxy-3-methyl-1-[4-(trifluoromethyl)benzyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-1-(Cyclopropyl(4-(difluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(difluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-tert-Butylphenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-tert-Butylphenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)ethyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)ethyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-(2,2,2-trifluoroethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-(2,2,2-trifluoroethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-isopropylphenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-isopropylphenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-isopropylphenyl)-2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-isopropylphenyl)-2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethyl)phenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethyl)phenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethoxy)phenyl)ethyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethoxy)phenyl)ethyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(2,2,2-trifluoroethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(2,2,2-trifluoroethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(2-methyl-1-(4-(2,2,2-trifluoroethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(2-methyl-1-(4-(2,2,2-trifluoroethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethyl)phenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethyl)phenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethyl)phenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethyl)phenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(3-fluoro-4-(2,2,2-trifluoroethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(3-fluoro-4-(2,2,2-trifluoroethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(2,2,2-trifluoroethyl)phenyl)propyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(2,2,2-trifluoroethyl)phenyl)propyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-(2,2,2-trifluoroethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-(2,2,2-trifluoroethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(2,2,2-trifluoroethyl)phenyl)ethyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(2,2,2-trifluoroethyl)phenyl)ethyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)phenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)phenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethyl)-3-fluorophenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethyl)-3-fluorophenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-2-fluorophenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)-2-fluorophenyl)ethyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-2-fluorophenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)-2-fluorophenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethyl)-3-fluorophenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethyl)-3-fluorophenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-2-fluorophenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)-2-fluorophenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethoxy)phenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethoxy)phenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(difluoromethoxy)-3-fluorophenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(difluoromethoxy)-3-fluorophenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethoxy)phenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethoxy)phenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethoxy)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethoxy)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(difluoromethoxy)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(difluoromethoxy)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)propyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)propyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(2-fluoro-4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(2-fluoro-4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)phenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)phenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)phenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)phenyl)-2-methylpropyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(1,1-difluoroethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(1,1-difluoroethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)propyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)propyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethyl)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethyl)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(difluoromethyl)-3-fluorophenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(difluoromethyl)-3-fluorophenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(hydroxymethyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-[(3-Chloropropyl)amino]-3-(hydroxymethyl)-1-{(1S)-1-[4-(trifluoromethyl)-phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
3-(Hydroxymethyl)-6-pyrrolidin-1-yl-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
6-Amino-3-(hydroxymethyl)-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-6-(Azetidin-1-yl)-3-(hydroxymethyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
6-(3,3-Difluoroazetidin-1-yl)-3-(hydroxymethyl)-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
3-(Hydroxymethyl)-6-(3-methylazetidin-1-yl)-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
6-(3-Fluoroazetidin-1-yl)-3-(hydroxymethyl)-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-6-(Dimethylamino)-3-(fluoromethyl)-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(fluoromethyl)-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(fluoromethyl)-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(fluoromethyl)-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethoxy)phenyl)ethyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethoxy)phenyl)ethyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)ethyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)ethyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-tert-Butylphenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-tert-Butylphenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(fluoromethyl)-1-(1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(fluoromethyl)-1-(1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(fluoromethyl)-1-(1-(4-(2,2,2-trifluoroethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(fluoromethyl)-1-(1-(4-(2,2,2-trifluoroethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-3-(fluoromethyl)-1-(1-(4-isopropylphenyl)-2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(fluoromethyl)-1-(1-(4-isopropylphenyl)-2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R−)-1-(Cyclopropyl(4-isopropylphenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-isopropylphenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethoxy)phenyl)-2-methylpropyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethoxy)phenyl)-2-methylpropyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(difluoromethoxy)-3-fluorophenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(difluoromethoxy)-3-fluorophenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethyl)phenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethyl)phenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(2,2,2-trifluoroethyl)phenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(2,2,2-trifluoroethyl)phenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)phenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)phenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethyl)-3-fluorophenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethyl)-3-fluorophenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)propyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)propyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(2-fluoro-4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(2-fluoro-4-(trifluoromethyl)phenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)phenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)phenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)phenyl)-2-methylpropyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)phenyl)-2-methylpropyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-2-fluorophenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)-2-fluorophenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)ethyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(1,1-difluoroethyl)phenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(1,1-difluoroethyl)phenyl)methyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-2-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)-2-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)-2-methylpropyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)-3-fluorophenyl)-2-methylpropyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)propyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)propyl)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(fluoromethyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Azetidin-1-yl-3-(fluoromethyl)-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
3-(Fluoromethyl)-6-pyrrolidin-1-yl-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
1-(1-(3-Fluoro-4-(trifluoromethoxy)phenyl)ethyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Hydroxy-3-(2,2,2-trifluoroethyl)-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Hydroxy-3-(2,2,2-trifluoroethyl)-1-(1-(4-(pentafluorosulfanyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-1-(2-methyl-1-(4-(trifluoromethoxy)phenyl)propyl)-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-1-(2-methyl-1-(4-(trifluoromethoxy)phenyl)propyl)-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-tert-Butylphenyl)ethyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-tert-Butylphenyl)ethyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethyl)phenyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethyl)phenyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(trifluoromethoxy)phenyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(trifluoromethoxy)phenyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-1-((1-methylcyclopropyl)(4-(trifluoromethyl)phenyl)methyl)-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-1-((1-methylcyclopropyl)(4-(trifluoromethyl)phenyl)methyl)-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2,2-dimethylpropyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2,2-dimethylpropyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-((3-Fluoro-4-(trifluoromethyl)phenyl)(1-methylcyclopropyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-((3-Fluoro-4-(trifluoromethyl)phenyl)(1-methylcyclopropyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-((4-tert-Butylphenyl)(cyclopropyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-((4-tert-Butylphenyl)(cyclopropyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethoxy)phenyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(3-fluoro-4-(trifluoromethoxy)phenyl)methyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-3-(trifluoromethyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-3-(trifluoromethyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-3-(2,2,2-trifluoroethyl)-1-{1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-6-Hydroxy-3-(2,2,2-trifluoroethyl)-1-{1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2-methylpropyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-tert-Butylphenyl)-2-methylpropyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-tert-Butylphenyl)-2-methylpropyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(2,2-Dimethyl-1-(4-(trifluoromethyl)phenyl)propyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(2,2-Dimethyl-1-(4-(trifluoromethyl)phenyl)propyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methylpropyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methylpropyl)-6-hydroxy-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-3-(perfluoroethyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-3-(perfluoroethyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
3-Methyl-6-pyrrolidin-1-yl-1-{1-[4-(trifluoromethyl)phenyl]ethyl})-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
3-Methyl-6-(methylamino)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
6-(Dimethylamino)-3-methyl-1-{1-[4-(trifluoromethyl)phenyl]ethyl})-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-3-(Difluoromethyl)-6-hydroxy-1-(3,3,3-trifluoro-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(Difluoromethyl)-6-hydroxy-1-(3,3,3-trifluoro-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-3-(Difluoromethyl)-6-hydroxy-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(Difluoromethyl)-6-hydroxy-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-Cyclopropylphenyl)ethyl)-3-(difluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-Cyclopropylphenyl)ethyl)-3-(difluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-3-(Difluoromethyl)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(Difluoromethyl)-1-(1-(3-fluoro-4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-3-(difluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-3-(difluoromethyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-3-(Difluoromethyl)-6-hydroxy-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(Difluoromethyl)-6-hydroxy-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-3-(Difluoromethyl)-1-(2,2-dimethyl-1-(4-(trifluoromethyl)phenyl)propyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(Difluoromethyl)-1-(2,2-dimethyl-1-(4-(trifluoromethyl)phenyl)propyl)-6-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-3-(Difluoromethyl)-6-hydroxy-1-(1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(Difluoromethyl)-6-hydroxy-1-(1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-3-(Difluoromethyl)-1-(1-(3-fluoro-4-(trifluoromethoxy)phenyl)ethyl)-6-hydroxy-H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(Difluoromethyl)-1-(1-(3-fluoro-4-(trifluoromethoxy)phenyl)ethyl)-6-hydroxy-H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(Difluoromethyl)-6-(dimethylamino)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Azetidin-1-yl-3-(difluoromethyl)-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-3-(2,2-Difluoroethyl)-6-hydroxy-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-3-(2,2-Difluoroethyl)-6-hydroxy-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-3-(2-hydroxyethyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R,S)-6-Hydroxy-3-(1-hydroxypropyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R,R)-6-Hydroxy-3-(1-hydroxypropyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S,S)-6-Hydroxy-3-(1-hydroxypropyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S,R)-6-Hydroxy-3-(1-hydroxypropyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-2-(1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-hydroxy-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-3-yl)acetonitrile,
(S)-2-(1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-hydroxy-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-3-yl)acetonitrile,
(S)-2-(6-Hydroxy-4-oxo-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-3-yl)acetonitrile,
(R)-2-(1-(1-(3-Fluoro-4-(trifluoromethoxy)phenyl)ethyl)-6-hydroxy-4-oxo-4,5-dihdro-1H-pyrazolo[3,4-d]pyrimidin-3-yl)acetonitrile,
(S)-2-(1-(1-(3-Fluoro-4-(trifluoromethoxy)phenyl)ethyl)-6-hydroxy-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-3-yl)acetonitrile,
(S)-3-(Hydroxymethyl)-6-(methylthio)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Ethoxy-3-(hydroxymethyl)-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-3-((Benzyloxy)methyl)-6-hydroxy-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-6-Hydroxy-3-(methoxymethyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-1-(1-(2-Fluoro-4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(2-Fluoro-4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-{1-[2-Fluoro-4-(trifluoromethoxy)phenyl]ethyl}-6-hydroxy-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-1-{1-[2-Fluoro-4-(trifluoromethoxy)phenyl]ethyl}-6-hydroxy-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-1-{1-[3-Fluoro-4-(trifluoromethoxy)phenyl]ethyl}-6-hydroxy-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-1-{1-[3-Fluoro-4-(trifluoromethoxy)phenyl]ethyl}-6-hydroxy-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-6-Hydroxy-1-{1-[4-(pentafluoro-lambda˜6˜-sulfanyl)phenyl]ethyl}-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-6-Hydroxy-1-{1-[4-(pentafluoro-lambda˜6˜-sulfanyl)phenyl]ethyl}-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-1-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]ethyl}-6-hydroxy-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-1-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]ethyl}-6-hydroxy-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-1-{1-[4-(Difluoromethoxy)phenyl]ethyl}-6-hydroxy-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(S)-1-{1-[4-(Difluoromethoxy)phenyl]ethyl}-6-hydroxy-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(2,2-Difluoroethyl)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(2,2-Difluoroethyl)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(3-Chloro-4-(trifluoromethoxy)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Chloro-4-(trifluoromethoxy)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethoxy)-3-fluorophenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethoxy)-3-fluorophenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
(R)-1-(1-(3-Chloro-4-(difluoromethoxy)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Chloro-4-(difluoromethoxy)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(3-Chloro-4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(3-Chloro-4-(trifluoromethyl)phenyl)ethyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-1-(1-(4-(trifluoromethoxy)phenyl)ethyl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-3-(trifluoromethyl)-1-(1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-hydroxy-3-(trifluoromethyl)-1-(1-(4-(trifluoromethyl)phenyl)propyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Hydroxy-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Hydroxy-1-(2-methyl-1-(4-(trifluoromethyl)phenyl)propyl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(trifluoromethyl)phenyl)methyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(2,2-Dimethyl-1-(4-(trifluoromethyl)phenyl)propyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(2,2-Dimethyl-1-(4-(trifluoromethyl)phenyl)propyl)-6-hydroxy-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-(Dimethylamino)-3-(trifluoromethyl)-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethoxy)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethoxy)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethoxy)-2-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethoxy)-2-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(Difluoromethyl)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethyl)-3-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
(R)-1-(1-(4-(Difluoromethyl)phenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(Difluoromethyl)phenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(difluoromethyl)-2-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(difluoromethyl)-2-fluorophenyl)propyl)-6-(dimethylamino)-3-(fluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(1,1-difluoroethyl)-3-fluorophenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(1,1-difluoroethyl)-3-fluorophenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(Cyclopropyl(4-(1,1-difluoroethyl)-2-fluorophenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(Cyclopropyl(4-(1,1-difluoroethyl)-2-fluorophenyl)methyl)-6-(dimethylamino)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Hydroxy-3-(trifluoromethyl)-1-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
6-Hydroxy-3-(trifluoromethyl)-1-(1-(4-(trifluoromethyl)phenyl)allyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-6-Amino-1-(1-(4-(1,1-difluoroethyl)phenyl)-2-methylpropyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-6-Amino-1-(1-(4-(1,1-difluoroethyl)phenyl)-2-methylpropyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(R)-1-(1-(4-(1,1-Difluoroethyl)phenyl)-2-methylpropyl)-3-(hydroxymethyl)-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
(S)-1-(1-(4-(1,1-Difluoroethyl)phenyl)-2-methylpropyl)-3-(hydroxymethyl)-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one,
or a pharmaceutically acceptable salt thereof.
19. A pharmaceutical composition which comprises a pharmaceutically acceptable carrier and a compound of claim 1 or a pharmaceutically acceptable salt thereof.