Triglyceride and use thereof
View Patent ↗The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to a triglyceride in which at least one fatty acid forming an ester bond with a hydroxy group of glycerol is 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.
1. A triglyceride in which at least one fatty acid forming an ester bond with a hydroxy group of glycerol is 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof.
2. The triglyceride or an optical isomer thereof according to claim 1 , wherein two fatty acids forming an ester bond with a hydroxy group of glycerol are each 10-hydroxy-cis-12-octadecenoic acid.
3. The triglyceride or an optical isomer thereof according to claim 1 , wherein three fatty acids forming an ester bond with a hydroxy group of glycerol are each 10-hydroxy-cis-12-octadecenoic acid.
4. The triglyceride or an optical isomer thereof according to claim 1 , wherein a fatty acid other than 10-hydroxy-cis-12-octadecenoic acid in the fatty acids forming an ester bond with a hydroxy group of glycerol is a fatty acid having a carbon number of 8-22.
5. The triglyceride or an optical isomer thereof according to claim 4 , wherein the fatty acid other than 10-hydroxy-cis-12-octadecenoic acid in the fatty acids forming an ester bond with a hydroxy group of glycerol is derived from an edible fat or oil.
6. The triglyceride or an optical isomer thereof according to claim 4 , wherein the fatty acid other than 10-hydroxy-cis-12-octadecenoic acid in the fatty acids forming an ester bond with a hydroxy group of glycerol is one or more kinds selected from the group consisting of linoleic acid, α-linolenic acid, γ-linolenic acid, stearidonic acid, oleic acid, stearic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, arachidic acid, pulmitoleic acid, elaidic acid, mead acid and dihomo-γ-linolenic acid.
7. The triglyceride or an optical isomer thereof according to claim 1 , which is liquid at ambient temperature.
8. An edible fat or oil comprising the triglyceride or an optical isomer thereof according to claim 1 .
9. A food or food additive comprising the triglyceride or an optical isomer thereof according to claim 1 .
10. A pharmaceutical composition comprising the triglyceride or an optical isomer thereof according to claim 1 .
11. An agent for the treatment of a disease selected from the group consisting of obesity, diabetes, lipid metabolism abnormality, hyperlipidemia, fatty liver, ulcerative colitis, Crohn's disease, ulcer, irritable bowel syndrome and inflammatory diseases, comprising the triglyceride or an optical isomer thereof according to claim 1 .
12. A cosmetic or cosmetic additive comprising the triglyceride or an optical isomer thereof according to claim 1 .
13. A feed or feed additive comprising the triglyceride or an optical isomer thereof according to claim 1 .
14. The triglyceride or an optical isomer thereof according to claim 2 , wherein a fatty acid other than 10-hydroxy-cis-12-octadecenoic acid in the fatty acids forming an ester bond with a hydroxy group of glycerol is a fatty acid having a carbon number of 8-22.
15. The triglyceride or an optical isomer thereof according to claim 14 , wherein the fatty acid other than 10-hydroxy-cis-12-octadecenoic acid in the fatty acids forming an ester bond with a hydroxy group of glycerol is derived from an edible fat or oil.
16. The triglyceride or an optical isomer thereof according to claim 14 , wherein the fatty acid other than 10-hydroxy-cis-12-octadecenoic acid in the fatty acids forming an ester bond with a hydroxy group of glycerol is one or more kinds selected from the group consisting of linoleic acid, α-linolenic acid, γ-linolenic acid, stearidonic acid, oleic acid, stearic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, arachidic acid, pulmitoleic acid, elaidic acid, mead acid and dihomo-γ-linolenic acid.
17. The triglyceride or an optical isomer thereof according to claim 1 , wherein one fatty acid forming an ester bond with a hydroxy group of glycerol is 10-hydroxy-cis-12-octadecenoic acid.
18. The triglyceride or an optical isomer thereof according to claim 17 , wherein two fatty acids other than 10-hydroxy-cis-12-octadecenoic acid in the fatty acids forming an ester bond with a hydroxy group of glycerol are fatty acids having a carbon number of 8-22.
19. The triglyceride or an optical isomer thereof according to claim 17 , wherein two fatty acids other than 10-hydroxy-cis-12-octadecenoic acid in the fatty acids forming an ester bond with a hydroxy group of glycerol are derived from an edible fat or oil.
20. The triglyceride or an optical isomer thereof according to claim 17 , wherein two fatty acids other than 10-hydroxy-cis-12-octadecenoic acid in the fatty acids forming an ester bond with a hydroxy group of glycerol are one or more kinds selected from the group consisting of linoleic acid, α-linolenic acid, γ-linolenic acid, stearidonic acid, oleic acid, stearic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, arachidic acid, pulmitoleic acid, elaidic acid, mead acid and dihomo-γ-linolenic acid.
21. The triglyceride or an optical isomer thereof according to claim 1 , which is liquid at 20° C.
22. The triglyceride or an optical isomer thereof according to claim 2 , which is liquid at 20° C.
23. The triglyceride or an optical isomer thereof according to claim 3 , which is liquid at 20° C.
24. The triglyceride or an optical isomer thereof according to claim 17 , which is liquid at 20° C.