10-hydroxy-cis-12-octadecenoic acid alkyl ester and use thereof
The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to an alkyl ester of 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, or ester of 10-hydroxy-cis-12-octadecenoic acid with dihydric alkanol or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.
1. A C 1-40 alkyl ester of 10-hydroxy-cis-12-octadecenoic acid or an optical isomer thereof, excluding methyl 10-hydroxy-cis-12-octadecenoate and ethyl 10-hydroxy-cis-12-octadecenoate.
2. The C 1-40 alkyl ester of 10-hydroxy-cis-12-octadecenoic acid or an optical isomer thereof according to claim 1 , which is liquid at ambient temperature.
3. Edible fat or oil comprising a C 1-40 alkyl ester of 10-hydroxy-cis-12-octadecenoic acid or an optical isomer thereof, excluding methyl 10-hydroxy-cis-12-octadecenoate.
4. A food or food additive comprising a C 1-40 alkyl ester of 10-hydroxy-cis-12-octadecenoic acid or an optical isomer thereof, excluding methyl 10-hydroxy-cis-12-octadecenoate and at least one substance selected from the group consisting of nutrients, vitamins, minerals, dietary fiber, food with reported physiological function, and general food additives.
5. A pharmaceutical composition comprising a C 1-40 alkyl ester of 10-hydroxy-cis-12-octadecenoic acid or an optical isomer thereof, excluding methyl 10-hydroxy-cis-12-octadecenoate and one or more pharmaceutically acceptable additives.
6. A cosmetic or cosmetics additive comprising a C 1-40 alkyl ester of 10-hydroxy-cis-12-octadecenoic acid or an optical isomer thereof, excluding methyl 10-hydroxy-cis-12-octadecenoate and one or more additives which are generally used for cosmetics.
7. A feed or feed additive comprising a C 1-40 alkyl ester of 10-hydroxy-cis-12-octadecenoic acid or an optical isomer thereof, excluding methyl 10-hydroxy-cis-12-octadecenoate and one or more filler substances, dilution substances, and combinations thereof for feed.
8. An ester of 10-hydroxy-cis-12-octadecenoic acid with C 1-8 alkyleneglycol, or an optical isomer thereof.
9. The ester or an optical isomer thereof according to claim 8 , which is liquid at ambient temperature.
10. A food or food additive comprising the ester or an optical isomer thereof according to claim 8 .
11. A pharmaceutical composition comprising the ester or an optical isomer thereof according to claim 8 and one or more pharmaceutically acceptable additives.
12. A cosmetic or cosmetics additive comprising the ester or an optical isomer thereof according to claim 8 and one or more additives which are generally used for cosmetics.
13. A method of treating a disease comprising administering an effective amount of the pharmaceutical composition of claim 5 to an animal having a disease selected from the group consisting of obesity, diabetes, hyperlipidemia, fatty liver, ulcerative colitis, Crohn's disease, ulcer, and irritable bowel syndrome, thereby treating the disease in the animal.
14. The C 1-40 alkyl ester of claim 1 , wherein the C 1-40 alkyl ester is a C 1-6 alkyl ester of 10-hydroxy-cis-12-octadecenoic acid or an optical isomer thereof, excluding methyl 10-hydroxy-cis-12-octadecenoate and ethyl 10-hydroxy-cis-12-octadecenoate.
15. The edible fat or oil of claim 3 , comprising a C 1-6 alkyl ester of 10-hydroxy-cis-12-octadecenoic acid or an optical isomer thereof, excluding methyl 10-hydroxy-cis-12-octadecenoate.
16. An ester of 10-hydroxy-cis-12-octadecenoic acid with C 2-6 alkyleneglycol, or an optical isomer thereof.