Method for treating pulmonary hypertension with interleukin-5 receptor antibody
The present invention relates to a therapeutic agent for pulmonary hypertension comprising an interleukin-5 receptor (hereinafter, abbreviated to “IL-5R”)-inhibiting compound and therapeutic method therefor. More specifically, the present invention relates to a therapeutic agent for pulmonary hypertension comprising an antibody or an antibody fragment capable of specifically binding to the extracellular region of IL-5R and a therapeutic method therefor.
1. A method for treating pulmonary hypertension, comprising administering an effective amount of an antibody or an antibody fragment thereof which binds to the extracellular region of an interleukin-5 receptor (IL-5R) to inhibit an IL-5R-expressing cell,
wherein said antibody or antibody fragment thereof comprises a heavy chain variable (VH) domain containing 3 complementarity determining regions (CDRs), and a light chain variable (VL) domain containing 3 CDRs,
wherein the 3 CDRs on said VH domain comprise the amino acid sequences of SEQ ID NOs: 1-3, respectively, and the 3 CDRs on said VL domain comprise the amino acid sequences of SEQ ID NOs: 4-6, respectively.
2. The method according to claim 1 , wherein the antibody has antibody-dependent cellular cytotoxic activity (ADCC activity).
3. The method according to claim 1 , wherein the antibody has IL-5R-neutralizing activity.
4. The method according to claim 1 , wherein the antibody inhibits group 2 innate lymphoid cell (ILC2)-dependent IL-5R-expressing cell growth.
5. The method according to claim 1 , wherein the method is characterized by at least one of the following (i) to (iii):
(i) the IL-5R-expressing cell is at least one cell of an eosinophil, a basophil, and a mast cell;
(ii) the method inhibits the growth of a vascular smooth muscle cell; and
(iii) the method inhibits pulmonary vascular remodeling.
6. The method according to claim 1 , wherein the antibody is any one antibody selected from a monoclonal antibody and a recombinant antibody.
7. The method according to claim 1 , wherein the antibody comprises a human Fc region or a human constant region.
8. The method according to claim 1 , wherein said VH domain comprises the amino acid sequence of SEQ ID NO: 7, and said VL domain comprises the amino acid sequence of SEQ ID NO: 8.
9. The method according to claim 1 , wherein said antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 9, and a light chain comprising the amino acid sequence of SEQ ID NO: 10.