Low intensity focused ultrasound for treating cancer and metastasis
Systems and methods for treating cancer and for preventing metastasis using low intensity focused ultrasound in combination with an anti-cancer therapy are disclosed.
1. An acoustic priming therapy device comprising:
a control system; and
one or more transducers coupled to the control system and configured to produce one or more ultrasound beams such that a waveform of the one or more ultrasound beams has a spatial peak temporal average acoustic output intensity (I spta ) of between 1 and 1000 W/cm 2 in a treatment zone, wherein the one or more ultrasound beams are applied for 0.5 to 5 seconds, wherein the one or more transducers produce one or more ultrasound frequencies in the range of 0.01 to 10 MHz, and wherein the one or more transducers comprise at least two transducers that are configured to produce columnated ultrasound such that the beam profile waist at −3 dB is not less than 5 mm in the treatment zone.
2. The device of claim 1 , wherein each of the one or more transducers is configured to produce one or more ultrasound frequencies in the range of 0.05 to 5 MHz or 0.5 to 1.5 MHz; and an I spta of between 20 and 1000 W/cm 2 .
3. The device of claim 1 , wherein a transducer of the one or more transducers comprises a single transducer element or multiple transducer elements.
4. The device of claim 3 , wherein the transducer comprises two or more transducers or transducer elements configured to produce two or more frequencies.
5. The device of claim 4 , wherein the two or more frequencies comprise a first ultrasound frequency within the range of 300 kHz to 3 MHz produced by one of the two or more transducers or transducer elements and a second ultrasound frequency within the range of 30 kHz to 300 kHz produced by one of the two or more transducers or transducer elements.
6. The device of claim 1 , wherein the one or more transducers comprise two or more ultrasound transducers that generate ultrasound beams that pass through the treatment zone, with each beam having an I spta in the treatment zone in the range of 10 to 500 W/cm 2 .
7. The device of claim 1 , wherein the one or more ultrasound beams produced by the one or more transducers is applied to the treatment zone of at least one cubic centimeter of tumor.
8. The device of claim 1 , wherein the one or more transducers comprise two transducers or three transducers that generate ultrasound beams that are substantially in phase and intersect within a treatment zone, wherein each beam has an I spta in the intersection zone in the range of 70 to 100 W/cm 2 , and wherein the ultrasound is applied continuously from 1 to 5 seconds per treatment zone.
9. The device of claim 1 , wherein the one or more transducers is configured to produce the one or more ultrasound beams for application to two or more volumes of a tumor over a period of time of less than one hour.
10. The device of claim 1 , wherein each of the one or more transducers is configured to produce the one or more ultrasound beams for applying an acoustic pressure to the treatment zone of 0.1 to 10 MPa and wherein the one or more transducers is configured with a duty cycle of 10, 20, 30, 40, 50, 60, 70, 80, 90%, or 100%.
11. The device of claim 1 , wherein the one or more transducers are configured to produce the one or more ultrasound beams in single frequency tones or multi-frequency chirps.
12. The device of claim 1 , wherein the one or more transducers are configured to produce the one or more ultrasound beams that raises a temperature in the treatment zone to less than 45° C.
13. The device of claim 1 , wherein the one or more transducers are configured to create an acoustic pressure in the treatment zone to induce a non-ablative stress in a tumor in the treatment zone.
14. The device of claim 1 , wherein the one or more transducers are configured to produce the one or more ultrasound beams have energy and intensity to prime immune system cells for a chemotherapeutic agent, wherein the energy and intensity fall between energies and intensities that induce ablative effects and that have diagnostic effects.
15. The device of claim 1 , wherein the one or more transducers comprise two or more transducers configured to operate sequentially in time and produce a low thermal dose and a mechanical vibration, wherein the thermal dose comprises a maximum temperature of 45° C. in the treatment zone.