IP Library Granted Patent US 11,642,069
Granted Patent B2
US 11,642,069 · App. 15/579,559 · Granted May 9, 2023

Diagnosis of mild traumatic brain injury

Inventors: Peter John Bergold (Brooklyn, NY); William Winzer Lytton (Scarsdale, NY); Joshua Michael Skolnick (Far Rockaway, NY)
Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
A61B5/4064A61B5/162A61B5/055A61B5/163A61B2505/09
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Quick Facts
Patent No.
US 11,642,069
App. No.
15/579,559
Granted
May 9, 2023
Kind
B2
Abstract

A stimulus is displayed in a visual field on a stimulus side (e.g., right or left) of a subject. An input is received from an input side of the subject. Where the input side is contralateral to the first stimulus side, a crossed reaction time is determined as a span of time between displaying the stimulus and receiving the input. Where the input side is ipsilateral to the stimulus side, an uncrossed reaction time is determined as a span of time between displaying the stimulus and receiving the input. A crossed-uncrossed difference time can be determined as a difference between the crossed reaction time and the uncrossed reaction time. The crossed reaction time, the uncrossed reaction time, and/or the crossed-uncrossed difference time can be used to determine a severity of Traumatic Brain Injury of the subject.

Claims (14)

1. A method, comprising:

displaying a stimulus in a peripheral visual field at least 30 degrees from a fixation point on a stimulus side of a subject, the peripheral visual field being a right peripheral visual field or a left peripheral visual field of the subject;

receiving an input, comprising an indication that the subject perceived the stimulus, from an input side of the subject, the input side being contralateral to the peripheral visual field;

measuring a crossed reaction time comprising a span of time between displaying the stimulus and receiving the input;

based on the crossed reaction time, determining a severity of a traumatic brain injury of the subject; and

after the determining the severity of the traumatic brain injury of the subject, administering to the subject a treatment based on the determined severity of the traumatic brain injury, the treatment comprising at least one of administering a drug to the subject, performing a surgery on the subject, or applying a stimulus to the brain of the subject.

2. The method of claim 1 , further comprising:

displaying a second stimulus in a second peripheral visual field at least 30 degrees from a fixation point on a second stimulus side of the subject, the second peripheral visual field being the right peripheral visual field or the left peripheral visual field of the subject;

receiving a second input, comprising an indication that the subject perceived the second stimulus, from a second input side of the subject, the second input side being ipsilateral to the second peripheral visual field;

measuring a crossed-uncrossed difference time as a difference between (i) the crossed reaction time and (ii) an uncrossed reaction time comprising a second span of time between displaying the second stimulus and receiving the second input; and

based on the crossed-uncrossed difference time, further determining the severity of the traumatic brain injury of the subject.

3. The method of claim 1 , wherein determining the severity of the traumatic brain injury comprises comparing the crossed reaction time of the subject to a crossed reaction time of a control subject not having a traumatic brain injury.

4. The method of claim 1 , further comprising: outputting to an output device the determined severity of the traumatic brain injury.

5. The method of claim 1 , further comprising: outputting to an output device a recommendation for the treatment for the administering.

Assignments (2)
CONFIRMATORY LICENSE Recorded Nov 17, 2023
From: STATE UNIVERSITY OF NEW YORK
To: UNITED STATES GOVERNMENT
Reel/Frame 065613/0703 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 9, 2018
From: BERGOLD, PETER JOHN; LYTTON, WILLIAM WINZER; SKOLNICK, JOSHUA MICHAEL
To: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Reel/Frame 047462/0278 →
Continuity (2)
Provisional Application 62171198 · Jun 4, 2015
Related Publication 20180168499A1 · Jun 21, 2018