Crystal forms of 6-bromo-3-hydroxy-2-pyrazinecarboxamide
The purpose of the present invention is to provide a method for producing 6-bromo-3-hydroxy-2-pyrazinecarboxamide in which the content ratio of impurities is reduced. This production method includes a step of obtaining 6-bromo-3-hydroxy-2-pyrazinecarboxamide crystal having diffraction angles expressed in degrees 2θ of 5.5, 20.1, 23.7, 26.7, 27.5, and 28.1° and/or diffraction angles expressed in degrees 2θ of 7.1, 21.4, 25.2, 25.7, 27.1, and 28.8° in powder X-ray diffraction.
1. A type-B crystal of 6-bromo-3-hydroxy-2-pyrazinecarboxamide having powder X-ray diffraction angles (2θ) of 7.1°, 21.4°, 25.2°, 25.7°, 27.1° and 28.8°.
2. A method for producing a type-B crystal of 6-bromo-3-hydroxy-2-pyrazinecarboxamide, wherein the method comprises:
reacting a type-A crystal of 6-bromo-3-hydroxy-2-pyrazinecarboxamide having powder X-ray diffraction angles (2θ) of 5.5°, 20.1°, 23.7°, 26.7°, 27.5° and 28.1° with a base, to produce a salt of the type-A crystal of 6-bromo-3-hydroxy-2-pyrazinecarboxamide; and
reacting the salt of the type-A crystal of 6-bromo-3-hydroxy-2-pyrazinecarboxamide with an acid, to produce a type-B crystal of 6-bromo-3-hydroxy-2-pyrazinecarboxamide having powder X-ray diffraction angles (2θ) of 7.1°, 21.4°, 25.2°, 25.7°, 27.1° and 28.8°.
3. The method of claim 2 , wherein the base is selected from the group consisting of sodium hydroxide, sodium hydrogen carbonate and potassium hydroxide, and a combination thereof.
4. The method of claim 2 , wherein the acid is selected from the group consisting of hydrochloric acid, nitric acid and sulfuric acid, and a combination thereof.