Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof
The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
1. (R)-3-Cyano-N-(3-(1-(cyclopentanecarbonyl)-2,2 dimethylpiperidin-4-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide or a pharmaceutically acceptable salt thereof.
2. A compound of structure
3. A pharmaceutical composition comprising (R)-3-cyano-N-(3-(1-(cyclopentanecarbonyl)-2,2 dimethylpiperidin-4-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier, excipient, or diluent.
4. A method of treating psoriasis in a patient comprising administering to the patient in need of such treatment a therapeutically effective amount of (R)-3-cyano-N-(3-(1-(cyclopentanecarbonyl)-2,2 dimethylpiperidin-4-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide, or a pharmaceutically acceptable salt thereof.
5. A method of treating psoriasis in a patient comprising administering to the patient in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of (R)-3-cyano-N-(3-(1-(cyclopentanecarbonyl)-2,2 dimethylpiperidin-4-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier, excipient, or diluent.