SHELF-STABLE MOUTH COATING GEL OR LIQUID
The disclosure provides dry, lipid-based mixtures comprising at least 50% by weight lipid molecules. The mixtures may comprise alkalizer molecules, non-hydrocolloidal emulsifiers and active ingredients, such as probiotic microorganisms, hyaluronan, and polyols (e.g. xylitol).
1 . A lipid-based mixture that is soothing for human and animal mouths, comprising:
(a) at least 50% by weight lipid molecules; and
(b) alkalizer molecules in an amount sufficient to give a pH of at least 7.0 when mixed with an amount of deionized water of pH 7.0 sufficient to give a water activity level of at least 0.95;
and wherein the mixture has a water activity level not greater than 0.7.
2 . The mixture of claim 1 , wherein at least 25% by weight of the lipid molecules are liquid at 40° C., and at least 6% by weight of the lipid molecules are solid at 40° C.
3 . The mixture of claim 1 , wherein the lipid molecules comprise vegetable oils.
4 . The mixture of claim 1 , further comprising:
(c) non-hydrocolloidal emulsifier molecules in a range of at least 0.1% and not greater than 15% of the lipid molecules by weight.
5 . The mixture of claim 4 ,wherein the non-hydrocolloidal emulsifier molecules are selected from the group consisting of mono-and diglycerides, polysorbate, lecithin, ammonium phosphatide, egg yolk, diacetyl tartaric acid esters, sodium or calcium stearoyl-2-lactylate, sorbitan tristearate, polyglycerol esters, lactic acid esters, citric acid esters, glycerin monostearate, potassium stearate, mono propylene glyco and polyglycerol polyricinoleate.
6 . The mixture of claim 4 ,wherein the non-hydrocolloidal emulsifier molecules comprise mono- and diglycerides in the range of 1.5% to 15% of the lipid molecules by weight.
7 . The mixture of claim 4 , wherein the non-hydrocolloidal emulsifier molecules comprise polysorbate 60 in the range of 0.1% to 2% of the lipid molecules by weight.
8 . The mixture of claim 1 , wherein when the alkalizer molecules are mixed with an amount of deionized water of pH 7.0 sufficient to give a water activity level of at least 0.95, the pH value is at least 7.0 and not greater than 8.8.
9 . The mixture of claim 8 , wherein the alkalizer molecules comprise a pH buffer pair of molecule species.
10 . The mixture of claim 9 , wherein the pH buffer pair of molecule species is mono-basic potassium phosphate and di-basic potassium phosphate, the species having a ratio to each other that buffers the pH to a value at least 7.0 and not greater than 8.0 when mixed with an amount of deionized water of pH 7.0 sufficient to give a water activity level of at least 0.95.
11 . The mixture of claim 1 further comprising:
(d) an active ingredient to be delivered topically in the mouth.
12 . The mixture of claim 11 , wherein the active ingredient is at least 5% by weight polyol grains.
13 . The mixture of claim 11 , wherein the active ingredient is at least 0.2% by weight hyaluronan molecules.
14 . The mixture of claim 11 , wherein the active ingredient is at least 0.01% by weight cobalamin molecules.
15 . The mixture of claim 11 wherein the active ingredient is at least 0.1% by weight cellulose gum molecules.
16 . The mixture of claim 11 , wherein the active ingredient is at least 0.01% by weight materials comprising one or more of calcium phosphate, casein phosphopeptide, and hydroxyapatite.
17 . The mixture of claim 11 , wherein the active ingredient is at least ten million viable bacteria per gram of mixture.
18 . A lipid-based mixture containing a polyol comprising:
(a) at least 50% by weight lipid molecules;
(b) at least 5% and not greater than 30% undissolved polyol grains by weight,
wherein average grain size of the polyol grains is less than 300 microns; and
wherein the mixture has a water activity level of not greater than 0.7.
19 . The mixture of claim 18 , wherein the polyol grains comprise xylitol.
20 . The mixture of claim 18 , wherein the polyol grains comprise erythritol.
21 . The mixture of claim 18 , wherein the polyol comprises at least 10% and not greater than 25% by weight.
22 . The mixture of claim 18 , wherein the lipid molecules comprise vegetable oils.
23 . The mixture of claim 18 , further comprising alkalizer molecules in an amount sufficient to give a pH at least 7.0 when the lipid-based mixture is mixed with an amount of deionized water of pH 7.0 sufficient to give a water activity level of at least 0.95;
24 .- 41 . (canceled)