IP Library › Granted Patent US 10,094,828
Granted Patent B2
US 10,094,828 · App. 15/587,842 · Granted Oct 9, 2018

Antigen composition for detecting Chagas disease

Inventors: Peter Muench (Penzberg, DE); Dieter Roessler (Kirchseeon, DE); Christian Scholz (Penzberg, DE); Barbara Upmeier (Iffeldorf, DE); Toralf Zarnt (Penzberg, DE)
G01N33/56905A61K39/005C07K14/44G01N33/564G01N2333/44G01N2469/20G01N2800/26
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Quick Facts
Patent No.
US 10,094,828
App. No.
15/587,842
Granted
Oct 9, 2018
Kind
B2
Abstract

The present invention concerns a composition of polypeptides suitable for detecting antibodies against Trypanosoma cruzi ( T. cruzi ) in an isolated biological sample consisting of three polypeptides 1F8, JL7 and Cruzipain. A method of producing a soluble and immunoreactive composition of polypeptides suitable for detecting antibodies against T. cruzi using said composition of polypeptides is also part of the invention. Moreover, the invention concerns a method for detecting antibodies specific for T. cruzi in an isolated sample wherein a composition of said T. cruzi polypeptides is used as well as a reagent kit comprising said composition of T. cruzi polypeptides.

Claims (3)

1. A composition of polypeptides suitable for detecting antibodies agains Trypanosoma cruzi in an isolated biological sample, said composition comprising three recombinantly or synthetically produced polypeptides specific for Trypanosoma cruzi , wherein said polypeptides are selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3.

2. A composition of polypeptides according to claim 1 wherein said composition comprises calcium ions in a concentration of 0.1 to 10 millions per liter.

3. A reagent kit for the detection of anti- Trypanosoma cruzi antibodies, comprising a composition of Trypanosoma cruzi polypeptides according to claim 1 .

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2017
From: SCHOLZ, CHRISTIAN; UPMEIER, BARBARA; ZARNT, TORALF; MUENCH, PETER; ROESSLER, DIETER
To: ROCHE DIAGNOSTICS GMBH
Reel/Frame 043141/0779 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2017
From: ROCHE DIAGNOSTICS GMBH
To: ROCHE DIAGNOSTICS OPERATIONS, INC.
Reel/Frame 043141/0802 →
Priority Claims (1)
EP 14192004 · Nov 6, 2014 · regional
Continuity (2)
Continuation PCTEP2015075691 · Nov 4, 2015
Related Publication 20170248597A1 · Aug 31, 2017