Trigeminal neurostimulation based upon pulse counting and chronobiology
Trigeminal nerves are stimulated based upon pulse counting and chronobiology. A cutaneous electrode assembly is applied to the forehead to stimulate the ophthalmic nerves. A method may include determining a number of pulses to be administered to a patient based upon the disorder being treated, and pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves with the determined number of pulses. Another method may include determining a pulse repetition frequency for pulses to be administered to a patient based upon the disorder being treated, and pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves at the pulse repetition frequency.
1. A method, comprising:
determining a number of pulses to be administered to a patient based upon a disorder being treated;
pulsing current through an electrode assembly to stimulate supraorbital and supratrochlear nerves on the patient with the determined number of pulses; and
tracking a number of administered pulses by counting the number of administered pulses or measuring an amount of time, wherein the pulsation of the current is stopped when the number of administered pulses reaches the determined number of pulses.
2. The method of claim 1 , further comprising:
determining whether the pulses should be administered with the patient awake or asleep based upon the disorder being treated; and
administering the pulses to the patient accordingly.
3. The method of claim 1 , further comprising:
determining whether the pulses should be administered at a particular time of day, in relationship to the intrinsic rhythms of the patient, based upon the disorder begin treated; and
administering the pulses to the patient accordingly.
4. The method of claim 1 , wherein the determining of the number of pulses is based on determining that the disorder is associated with an undesirably low activity in a brain region.
5. The method of claim 4 , wherein the disorder is a mood disorder, a cognitive disorder, a pain disorder, a behavioral disorder, a movement disorder, or a disorder due to a brain injury or a traumatic experience.
6. The method of claim 4 , wherein the pulsing is at a pulse repetition frequency that is above a threshold for increasing activity in the brain region and below a threshold for synaptic fatigue of the neurons of the supraorbital and supratrochlear nerves.
7. The method of claim 6 , wherein the pulse repetition frequency is below 100 Hz.
8. The method of claim 1 , further comprising tracking a number of administered pulses during the pulsing by counting the number of administered pulses or measuring an amount of time, wherein the pulsing of the current is stopped when the number of administered pulses reaches the determined number of pulses.
9. The method of claim 1 , wherein the electrode assembly is a cutaneous electrode assembly, the method further comprising applying the cutaneous electrode assembly to the patient's forehead by aligning a midline of the cutaneous electrode assembly with the patient's nasal midline, and adhering the aligned cutaneous electrode assembly to the patient's forehead such that a first electrode contact overlays a first ophthalmic nerve pair on a first side of the patient's forehead and such that a second electrode contact overlays a second ophthalmic nerve pair on an opposing side of the patient's forehead.
10. A method, comprising:
determining a pulse repetition frequency for pulses to be administered to a patient based upon a disorder being treated;
pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves at the pulse repetition frequency; and
tracking a number of administered pulses by counting the number of administered pulses or measuring an amount of time, wherein the pulsation of the current is stopped when the number of administered pulses reaches the determined number of pulses.
11. The method of claim 10 , further comprising:
determining whether the pulses should be administered with the patient awake or asleep based upon the disorder being treated; and
administering the pulses to the patient accordingly.
12. The method of claim 10 , further comprising:
determining whether the pulses should be administered at a particular time of day, in relationship to the intrinsic rhythms of the patient, based upon the disorder begin treated; and
administering the pulses to the patient accordingly.
13. The method of claim 10 , wherein the determining of the pulse repetition frequency is based on determining the disorder is associated with an undesirably high activity in a brain region.
14. The method of claim 13 , wherein the disorder is a seizure disorder, a pain disorder, a movement disorder, a behavioral disorder, a mood disorder, or a disorder due to a brain injury or a traumatic experience.
15. The method of claim 10 , wherein the pulse repetition frequency exceeds a threshold for synaptic fatigue of the neurons of the supraorbital and supratrochlear nerves.
16. The method of claim 15 , wherein the pulse repetition frequency is between 100 Hz and 500 Hz.
17. The method of claim 10 , wherein the electrode assembly is a cutaneous electrode assembly, the method further comprising applying the cutaneous electrode assembly to the patient's forehead by aligning a midline of the cutaneous electrode assembly with the patient's nasal midline, and adhering the aligned cutaneous electrode assembly to the patient's forehead such that a first electrode contact overlays a first ophthalmic nerve pair on a first side of the patient's forehead and such that a second electrode contact overlays a second ophthalmic nerve pair on an opposing side of the patient's forehead.
18. A system comprising:
an electrode assembly; and
a pulse generator communicatively coupled to the electrode assembly, the pulse generator configured to:
determine a number of pulses to be administered to the patient based upon a disease to be treated;
pulse current through the electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves; and
track a number of administered pulses by counting the number of administered pulses or measuring an amount of time, wherein the pulsation of the current is stopped when the number of administered pulses reaches the determined number of pulses.
19. The system of claim 18 , wherein the pulse generator is configured to:
determine whether the pulses are to be administered while the patient is awake, asleep, or both;
determine whether the patient is awake or asleep; and
pulse the current based on whether the patient is awake or asleep.
20. The system of claim 18 , wherein the pulse generator is configured to:
determine whether the pulses are to be administered at a particular time of day, in relationship to the intrinsic rhythms of the patient, based upon the disorder begin treated;
determine a time of day; and
pulse the current based on the time of day.