IP Library › Granted Patent US 10,213,502
Granted Patent B2
US 10,213,502 · App. 15/607,203 · Granted Feb 26, 2019

Vaccine for falciparum malaria

Inventors: Jonathan Kurtis (Providence, RI); Christian Parcher Nixon (Little Compton, RI); Dipak Kumar Raj (Pawtucket, RI); Jennifer Frances Friedman (Providence, RI); Michal Fried (Rockville, MD); Patrick Emmet Duffy (Washington, DC)
Assignees: Rhode Island Hospital; Seattle Biomedical Research Institute
A61K39/015A61K39/39575C07K14/445C07K16/205C07K16/44A61K2039/505A61K2039/522A61K2039/54A61K2039/55A61K2039/575C07K2317/34C07K2317/76Y02A50/412
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Quick Facts
Patent No.
US 10,213,502
App. No.
15/607,203
Granted
Feb 26, 2019
Kind
B2
Abstract

The invention provides compositions and methods for preventing or reducing the severity of malaria.

Claims (7)

1. A method of treating P. falciparum malaria in a subject or vaccinating against malaria comprising administering to the subject a composition comprising a purified PfGARP polypeptide antigen comprising the amino acid sequence of SEQ ID NO: 27 or a purified antigenic fragment thereof comprising the amino acid sequence of SEQ ID NO: 26.

2. The method of claim 1 , wherein said purified antigen or antigenic fragment thereof comprising the amino acid sequence of SEQ ID NO: 26 elicits an antibody immune response against PfGARP.

3. The method of claim 1 , wherein said subject is at least about 6-8 weeks of age.

4. The method of claim 1 , wherein said subject is an adolescent female or a female of childbearing age.

5. The method of claim 1 , wherein said composition is administered intramuscularly.

6. The method of claim 1 , further comprising administering a second vaccine.

7. The method of claim 6 , said second vaccine comprises RTS,S (Mosquirix) or MSP-1.

Assignments (4)
CONFIRMATORY LICENSE Recorded Dec 15, 2022
From: RHODE ISLAND HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 062136/0259 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 26, 2019
From: SEATTLE BIOMEDICAL RESEARCH INSTITUTE
To: SEATTLE CHILDREN'S HOSPITAL DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE
Reel/Frame 048698/0782 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2017
From: FRIED, MICHAL; DUFFY, PATRICK EMMET
To: SEATTLE BIOMEDICAL RESEARCH INSTITUTE
Reel/Frame 043303/0710 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2017
From: KURTIS, JONATHAN; NIXON, CHRISTIAN PARCHER; RAJ, DIPAK KUMAR; FRIEDMAN, JENNIFER FRANCES
To: RHODE ISLAND HOSPITAL
Reel/Frame 043303/0735 →
Continuity (4)
Continuation 14361573
Provisional Application 61641445 · May 2, 2012
Provisional Application 61566365 · Dec 2, 2011
Related Publication 20170326219A1 · Nov 16, 2017
Cited By (1)
US 12,214,026