Multiple treatment zone ablation probe
An energy delivery probe and method of using the energy delivery probe to treat a patient is provided herein. The energy delivery probe has at least one probe body having a longitudinal axis and at least a first trocar and a second trocar. Each trocar comprises at least two electrodes that are electrically insulated from each other, and each electrode is independently selectively activatable. An insulative sleeve is positioned in a coaxially surrounding relationship to each of the first trocar and the second trocar. The probe also has a switching means for independently activating at least one electrode. The method involves independently and selectively activating the first and second electrodes to form an ablation zone, then repeating the ablation by delivering energy to a second set of electrodes, producing one or more overlapping ablation zone, and eliminating the need to reposition the ablation probes.
1. A system of treating a tissue in a patient, the system comprising:
at least one bipolar energy delivery probe, the at least one bipolar energy delivery probe comprising a shaft and a lumen, at least one fluid channel, the at least one fluid channel extending through the lumen of the at least one bipolar energy delivery probe, and at least a first electrode and a second electrode located on the shaft, wherein each electrode is independently activatable;
an energy delivery source adapted to deliver electrical energy to the at least one energy delivery probe, the energy delivery source is capable of delivering electrical pulses sufficient to irreversible electroporate the tissue;
an insulator coaxially surrounding at least a portion of the probe, the insulator positioned between the first electrode and the second electrode;
a switching means configured to activate the first electrode to deliver the electrical energy to the second electrode, delivering energy between the first electrode and the second electrode, the switching means alternating the electrodes by activating the second electrode to deliver the electrical energy to the first electrode, and delivering electrical energy between the second and the first electrode.
2. The system of claim 1 , wherein the at least one bipolar energy probe further comprises temperature feedback sensor.
3. The system of claim 1 , wherein the at least one bipolar energy probe is stationary during the delivery of the energy.
4. The system of claim 1 , wherein the energy delivery source can deliver energy of at least 500V.
5. The system of claim 1 , wherein the energy delivery source can deliver a pulse length of at least 20 μs.
6. The system of claim 1 , wherein the energy delivered comprises a pulse parameter comprising a first set of five individual pulses, followed by a first delay of up to 2 seconds, followed by a second set of five pulses, followed by a second delay of up to 10 seconds.
7. The system of claim 1 , wherein the at least one bipolar energy probe further comprises an anchoring means at a distal end of the at least one bipolar energy probe.
8. The system of claim 7 , wherein the anchoring means is movable independent of the at least one bipolar energy probe.
9. The system of claim 1 , further comprising a fluid source, the fluid source in fluid communication with the at least one fluid channel for recirculation of a fluid through the at least one bipolar energy probe.
10. The system of claim 9 , wherein the fluid comprises a temperature control fluid.
11. A method of treating tissue in a patient, the method comprising:
identifying a target tissue;
inserting at least one bipolar energy delivery probe into or near the target tissue, the at least one bipolar energy delivery probe comprising a shaft and a lumen, at least one fluid channel extending through the lumen of the at least one bipolar energy delivery probe, and at least a first electrode and a second electrode, wherein each electrode is independently activatable;
an insulator coaxially surrounding at least a section the probe, the insulator positioned between the first electrode and the second electrode;
infusing a temperature control fluid through at least one fluid channel;
recirculating the temperature control fluid through the at least one fluid channel;
activating an energy delivery source adapted to deliver energy to the at least one bipolar energy delivery probe, the energy capable of irreversibly electroporating cells in the tissue in the patient;
delivering energy between the first and second electrode;
switching the activation of the electrodes such that the second electrode is activated to deliver the electrical energy to the first electrode;
delivering electrical energy between the second electrode and the first electrode; and
forming an ablation zone.
12. The method of claim 11 , wherein the at least one bipolar energy probe further comprises temperature feedback circuitry.
13. The method of claim 11 , wherein the at least one bipolar energy probe is not repositioned during the delivery of energy.
14. The method of claim 11 , wherein the energy delivery source can deliver energy of at least 500V.
15. The method of claim 11 , wherein the energy delivery source can delivery a pulse length of at least 20 μs.
16. The method of claim 11 , wherein the energy delivered comprises a pulse parameter comprising a first set of five individual pulses, followed by a first delay of up to 2 seconds, followed by a second set of five pulses, followed by a second delay of up to 10 seconds.
17. The method of claim 11 , wherein the at least one bipolar energy probe further comprises an anchoring means at a distal end of the at least one bipolar energy probe.
18. The method of claim 17 , wherein the anchoring means is movable independent of the at least one bipolar energy probe.