Drug delivery polymers and uses thereof

1. A platinum complex of Formula (I):

or a salt thereof, wherein:

each instance of R N1 is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, or a nitrogen protecting group, or two R N1 are taken with the intervening atoms to form a heterocyclic ring;

each instance of R N2 is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, or a nitrogen protecting group, or two R N2 are taken with the intervening atoms to form a heterocyclic ring;

L N is a linker selected from the group consisting of substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocyclylene, and combinations thereof; and

each instance of n is 1, 2, 3, 4, 5, or 6.

2. The platinum complex of claim 1 , wherein the platinum complex is of Formula (I-a):

or a salt thereof, wherein:

each instance of R A is independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and

each instance of R B is independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

or two instances of R B are joined to form a substituted or unsubstituted, carbocyclic ring, or substituted or unsubstituted, heterocyclic ring.

3. The platinum complex of claim 2 , wherein the platinum complex is of Formula (I-b):

or a salt thereof.

4. The platinum complex of claim 2 , wherein the platinum complex is of Formula (I-c):

or a salt thereof, wherein:

Ring A is a substituted or unsubstituted, monocyclic, 3- to 7-membered carbocyclic ring;

each instance of R C is independently halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —OR a , —N(R a ) 2 , —SR a , —CN, —SCN, —C(═NR a )R a , —C(═NR a )OR a , —C(═NR a )N(R a ) 2 , —C(═O)R a , —C(═O)OR a , —C(═O)N(R a ) 2 , —NO 2 , —N(R a )C(═O)R a , —N(R a )C(═O)OR a , —N(R a )C(═O)N(R a ) 2 , —N(R a )S(═O)R a , —N(R a )S(═O)OR a , —N(R a )S(═O)N(R a ) 2 , —N(R a )S(═O) 2 R a , —N(R a )S(═O) 2 OR a , —N(R a )S(═O) 2 N(R a ) 2 , —OC(═O)R a , —OC(═O)OR a , or —OC(═O)N(R a ) 2 ;

each instance of R a is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of R a are joined to form a substituted or unsubstituted, heterocyclic ring, or substituted or unsubstituted, heteroaryl ring; and

u is an integer between 0 and 8, inclusive.

5. The platinum complex of claim 4 , wherein the platinum complex is of Formula (I-d):

or a salt thereof.

6. The platinum complex of claim 4 , wherein the platinum complex is of Formula (I-e):

or a salt thereof, wherein u is an integer between 0 and 8, inclusive.

7. The platinum complex of claim 1 , wherein the platinum complex is of Formula (I-f):

or a salt thereof.

8. The platinum complex of claim 1 , or a salt thereof, wherein each instance of R N1 is hydrogen, and each instance of R N2 is hydrogen.

9. The platinum complex of claim 1 , or a salt thereof, wherein L N is substituted or unsubstituted heterocyclylene or substituted or unsubstituted cycloalkylene.

10. The platinum complex of claim 1 , wherein L N is substituted or unsubstituted cycloalkylene.

11. The platinum complex of claim 1 , wherein n is 1.

12. The platinum complex of claim 1 , or a salt thereof, wherein each instance of

is of the formula:

13. The platinum complex of claim 2 , wherein each instance of R A is hydrogen.

14. The platinum complex of claim 4 , wherein u is 0.

15. The platinum complex of claim 1 , wherein the platinum complex is of the formula:

16. The platinum complex of claim 1 , wherein the platinum complex is of the formula:

17. The platinum complex of claim 2 , wherein two instances of R B are joined to form a substituted or unsubstituted, carbocyclic ring, or substituted or unsubstituted, heterocyclic ring.

18. The platinum complex of claim 2 , wherein two instances of R B are joined to form a substituted or unsubstituted, carbocyclic ring.

19. A method of preparing a platinum complex of claim 1 , or a salt thereof, the method comprising the steps of:

(a) oxidizing a compound of Formula (S-1):

with an oxidant to provide a compound of Formula (S-2):

and

(b) coupling the compound of Formula (S-2) with a compound of Formula (S-3):

to provide the platinum complex, or the salt thereof.

20. The method of claim 19 , wherein the oxidant is H 2 O 2 .

21. The method of claim 19 , wherein the step of coupling is performed in the presence of an activator.

22. The method of claim 21 , wherein the activator is N,N′-dicyclohexylcarbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, O-(7-azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphonate, or (2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate).