Hest G-18-0 and benzoyl peroxide compositions and methods for using the same
The compositions of the various embodiments include benzoyl peroxide and Hest G-18-0. The methods of this invention include treating acne, increasing the solubility of benzoyl peroxide, and treating the skin. Embodiments are also directed to a dual chamber package comprising a chamber for benzoyl peroxide and a chamber for Hest G-18-0.
1. A topical composition consisting essentially of:
a first composition containing about 5% by weight of benzoyl peroxide, an effective amount of tocopherol, and a cosmetically acceptable excipient; and
a second composition containing about 15% by weight of Hest G-18-0, an effective amount of Vaccinium Angustifolium (Blueberry) fruit extract, and a cosmetically acceptable excipient,
wherein the first and the second compositions are combined before use to form the topical composition, and wherein the benzoyl peroxide is solubilized in the Hest G-18-0.
2. A method of treating acne comprising applying to a subject's skin a topical composition consisting essentially of: a first composition containing about 5% by weight of benzoyl peroxide, an effective amount of tocopherol, and a cosmetically acceptable excipient; and a second composition containing about 15% by weight of Hest G-18-0, an effective amount of Vaccinium Angustifolium (Blueberry) fruit extract, and a cosmetically acceptable excipient, wherein the first and the second compositions are combined before use to form the topical composition, and wherein the benzoyl peroxide is solubilized in the Hest G-18-0.
3. The method of claim 2 , wherein the benzoyl peroxide solubility is increased in the topical composition prior to, during, or after the application to the subject's skin.
4. The method of claim 2 , wherein the benzoyl peroxide efficacy is increased as part of the topical composition.
5. The method of claim 2 , wherein skin erythema, skin irritation, drying of the skin, cracking of the skin, and appearance of white residue on the skin is reduced as part of the topical composition.
6. The method of claim 2 , wherein subject compliance is increased.
7. A dual chamber package consisting essentially of:
a first chamber containing a first composition containing about 5% by weight of benzoyl peroxide, an effective amount of tocopherol, and a cosmetically acceptable excipient; and
a second chamber containing a second composition containing about 15% by weight of Hest G-18-0, an effective amount of Vaccinium Angustifolium (Blueberry) fruit extract, and a cosmetically acceptable excipient.
8. The package of claim 7 , wherein the benzoyl peroxide is at a concentration of about 2.5% by weight of a final topical composition upon mixing of the first and second compositions.
9. The package of claim 7 , wherein the first composition and the second composition are mixed within the package at a time of application to a subject's skin.
10. The package of claim 7 , wherein the first composition and the second composition are applied simultaneously or sequentially applied to a subject's skin.
11. The topical composition of claim 1 , wherein the benzoyl peroxide is at a concentration of about 2.5% by weight of the topical composition upon mixing of the first and second compositions.
12. The topical composition of claim 1 , wherein the cosmetically acceptable excipient of the first composition is selected from the group consisting of polysaccharide polymer, glycerin, butylene glycol, acrylamide/sodium acryloyodimethyltaurate copolymer, isohexadecane, phenoxyethanol,polysorbate 80, ethylhexylglycerin, sodium hydroxide, dipropylene glycol, pentylene glycol, polyethylene glycol, ethanol, water, and combinations thereof.
13. The package of claim 7 , wherein the Hest G-18-0 is at a concentration of about 7.5% by weight of a topical composition upon mixing of the first and second compositions.
14. The package of claim 7 , wherein the cosmetically acceptable excipient of the first composition is selected from the group consisting of polysaccharide polymer, glycerin, butylene glycol, acrylamide/sodium acryloyodimethyltaurate copolymer, isohexadecane, phenoxyethanol, polysorbate 80 , ethylhexylglycerin, sodium hydroxide, dipropylene glycol, pentylene glycol, polyethylene glycol, ethanol, water, and combinations thereof.
15. The topical composition of claim 1 , wherein the cosmetically acceptable excipient of the second composition is selected from the group consisting of polysaccharide polymer, glycerin, butylene glycol, propanediol, dimethyl isosorbide, acrylamide/sodium acryloyodimethyltaurate copolymer, propylene glycol, phenoxyethanol, isohexadecane, methyl methacrylate crosspolymer, polysorbate 80, ethylhexylglycerin, 1,2-hexanediol, cetyl hydroxyethylcellulose, dipropylene glycol, pentylene glycol, polyethylene glycol, ethanol, water, and combinations thereof.
16. The package of claim 7 , wherein the cosmetically acceptable excipient of the second composition is selected from the group consisting of polysaccharide polymer, glycerin, butylene glycol, propanediol, dimethyl isosorbide, acrylamide/sodium acryloyodimethyltaurate copolymer, propylene glycol, phenoxyethanol, isohexadecane, methyl methacrylate crosspolymer, polysorbate 80, ethylhexylglycerin, 1,2-hexanediol, cetyl hydroxyethylcellulose, dipropylene glycol, pentylene glycol, polyethylene glycol, ethanol, water, and combinations thereof.
17. The method of claim 2 , wherein the cosmetically acceptable excipient of the first composition is selected from the group consisting of polysaccharide polymer, glycerin, butylene glycol, acrylamide/sodium acryloyodimethyltaurate copolymer, isohexadecane, phenoxyethanol,polysorbate 80, ethylhexylglycerin, sodium hydroxide, dipropylene glycol, pentylene glycol, polyethylene glycol, ethanol, water, and combinations thereof.
18. The method of claim 2 , wherein the cosmetically acceptable excipient of the second composition is selected from the group consisting of polysaccharide polymer, glycerin, butylene glycol, propanediol, dimethyl isosorbide, acrylamide/sodium acryloyodimethyltaurate copolymer, propylene glycol, phenoxyethanol, isohexadecane, methyl methacrylate crosspolymer, polysorbate 80, ethylhexylglycerin, 1,2-hexanediol, cetyl hydroxyethylcellulose, dipropylene glycol, pentylene glycol, polyethylene glycol, ethanol, water, and combinations thereof.
19. The topical composition of claim 1 , wherein the Hest G-18-0 is at a concentration of about 7.5% by weight of a topical composition upon mixing of the first and second compositions.
20. The method of claim 2 , wherein the benzoyl peroxide is at a concentration of about 2.5% by weight of the topical composition upon mixing of the first and second compositions.
21. The method of claim 2 , wherein the Hest G-18-0 is at a concentration of about 7.5% by weight of the topical composition upon mixing of the first and second compositions.
22. The topical composition of claim 1 , wherein neither the first composition nor the second composition contain adapalene.
23. The method of claim 2 , wherein neither the first composition nor the second composition contain adapalene.
24. The package of claim 7 , wherein neither the first composition nor the second composition contain adapalene.