Agent for prevention and treatment of osteoporosis and its uses
A mineral-vitamin complex for osteoporosis includes at least 92 mass % of the mineral-vitamin complex of amino acids and Krebs cycle acids and/or Krebs cycle acid salts, wherein the amino acids include glycine of between 1% and 80% of the mineral-vitamin complex, and wherein the Krebs cycle acids and/or Krebs cycle acid salts are up to 5 mass % of the mineral-vitamin complex; and valine, leucine and isoleucine such that a mass ratio of glycine to a sum of valine+leucine+isoleucine is in a range of 10-1000. Optionally, the valine, leucine and isoleucine are derived from dry milk, any stable dry product derived from milk and/or a mix thereof. Optionally, the following compounds are used as a source of Krebs cycle acid salts: Y-Me-Y.nH 2 O, where Me—divalent metal, from Ca, Mg, Zn group, Y—anion of an acid participating in Krebs cycle, and n=0-12.
1. A compound for prevention and treatment of osteoporosis, comprising:
a mineral-vitamin complex, wherein the mineral-vitamin complex is up to 92 mass % of the compound,
wherein the mineral-vitamin complex includes fumaric, succinic and/or malic acids, and/or salts of Ca, Mg and/or Zinc derived from Y-Me-Y.nH 2 O, where
Me is Ca, Mg or Zn,
Y is an anion of fumaric, succinic and malic acids, and
n=0-12,
wherein the vitamins are up to 5 mass % the mineral-vitamin complex include any of vitamin D-group, vitamin B-group, vitamin E, and/or a combination thereof,
wherein the amino acids include glycine between 1 mass % and 80 mass % of the mineral-vitamin complex,
wherein the amino acids also include between 5 mass % and 86 mass % of the mineral-vitamin complex of glutamic acid, sodium glutamate and/or aspartic acids; and
valine, leucine and isoleucine such that a mass ratio of glycine to a sum of valine+leucine+isoleucine is in a range of 10-1000, and is no more than 8 mass % of the compound.
2. The mineral-vitamin complex of claim 1 , the valine, leucine and isoleucine are derived from dry milk, any stable dry product derived from milk and/or a mix thereof.
3. The mineral-vitamin complex of claim 1 , wherein the composition is in a form tablets, capsules, dragée, powder, pastilles, suspension, or a solution.
4. The mineral-vitamin complex of claim 3 , further comprising sugar and/or sweeteners and/or microcrystalline cellulose and/or technological additive and ballast products.
5. A method of prevention and treatment of osteoporosis, comprising providing, to a patient a compound that comprises:
a mineral-vitamin complex, wherein the mineral-vitamin complex is up to 92 mass % of the compound,
wherein the mineral-vitamin complex includes fumaric, succinic and/or malic acids, and/or salts of Ca, Mg and/or Zinc derived from Y-Me-Y.nH 2 O, where
Me is Ca, Mg or Zn,
Y is an anion of fumaric, succinic and malic acids, and
n=0-12,
wherein the vitamins are up to 5 mass % the mineral-vitamin complex include any of vitamin D-group, vitamin B-group, vitamin E, and/or a combination thereof,
wherein the amino acids include glycine between 1 mass % and 80 mass % of the mineral-vitamin complex,
wherein the amino acids also include between 5 mass % and 86 mass % of the mineral-vitamin complex of glutamic acid, sodium glutamate and/or aspartic acids; and
valine, leucine and isoleucine such that a mass ratio of glycine to a sum of valine+leucine+isoleucine is in a range of 10-1000, and is no more than 8 mass % of the compound.
6. The method of claim 5 , wherein a delivery of the composition is a long course of treatment or a continuous delivery.