Nicotine-containing pharmaceutical compositions
A composition intended to be employed for therapeutic purposes incorporates nicotine and at least one other nicotinic compound. Representative forms of nicotine can be as a free base (e.g., as a mixture of nicotine and microcrystalline cellulose), as a form of nicotine salt (e.g., as nicotine bitartrate) or as nicotine polacrilex. The other nicotinic compound is a compound that can be considered to bind selectively to certain nicotinic receptor subtypes, and particularly those of the central nervous system. For example, the other nicotinic compound can be a compound that binds selectively to the nicotinic receptor subtypes α 7 or α 4 β 2 . The composition is useful for treatment of central nervous system conditions, diseases and disorders, and as a nicotine replacement therapy.
1. A composition comprising:
nicotine; and
an agonist or pharmaceutically acceptable salt thereof, having selectivity to an α 7 nicotinic receptor subtype, wherein the agonist is selected form the group consisting of N-[(2S,3S)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-2-carboxamide,(5aS,8S,10aR)-5a,6,9,10-Tetrahydro,7H,11H-8,10a-methanopyrido[2′,3′:5,6]pyrano[2,3-d]azepine, 1,4-Diazabicyclo[3.2.2]nonane-4-carboxylic acid, 4-bromophenyl ester, 3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine, 2-methyl-5-(6-phenyl-pyridazin-3-yl)-octahydro-pyrrolo[3,4-c]pyrrole, (5S)-spiro[1,3-oxazolidine -5,8′-1-azabicyclo[2.2.2]octane]-2-one, N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide,5-morpholin-4-yl-pentanoic acid (4-pyridin-3-yl-phenyl)-amide, EVP-6124, EVP-4473, TC-6987, and MEM3454;
wherein the composition is in a pharmaceutically acceptable form provided in a single dosage form.
2. The composition of claim 1 , wherein the agonist is N-[(2S,3S)-2-(pyridin-3-ylmethyl)-1-azabicyclo [2.2.2]oct-3-yl]-1-benzofuran-2-carboxamide.
3. The composition of claim 1 , wherein the nicotine is in the form of a free base, a salt, a complex, or a solvate.
4. The composition of claim 3 , wherein the nicotine is nicotine polacrilex, nicotine free base, nicotine tartrate or nicotine bitartrate.
5. The composition of claim 1 , wherein the composition is in a form adapted for oral ingestion.
6. The composition of claim 5 , wherein the pharmaceutically acceptable form is selected from the group consisting of a pill, tablet, lozenge, mini lozenge, capsule, caplet, pouch, gum and spray.
7. The composition of claim 1 , wherein the nicotine is nicotine polacrilex, nicotine free base, nicotine tartrate or nicotine bitartrate; and wherein the pharmaceutically acceptable form is a gum, lozenge, pouch or spray.
8. The composition of claim 1 , wherein one or both of the nicotine and the agonist are sorbed onto a porous particulate carrier.
9. The composition of claim 8 , wherein the porous particulate carrier comprises microcrystalline cellulose.
10. A method for treating a condition, disease or disorder responsive to stimulation of nicotinic acetylcholinergic receptors, comprising:
orally or nasally administering an effective amount of a pharmaceutical composition to a human subject, the pharmaceutical composition comprising:
nicotine; and
an agonist or pharmaceutically acceptable salt thereof, having selectivity to an α 7 nicotinic receptor subtype, wherein the agonist is selected form the group consisting of N-[(2S,3S)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-2-carboxamide,(5aS,8S,10aR)-5a,6,9,10-Tetrahydro,7H,11H-8,10a -methanopyrido[2′,3′:5,6]pyrano[2,3-d]azepine, 1,4-Diazabicyclo[3.2.2]nonane-4-carboxylic acid,4-bromophenyl ester, 3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine, 2-methyl-5-(6-phenyl-pyridazin-3-yl)-octahydro-pyrrolo[3,4-c]pyrrole, (5S)-spiro[1,3-oxazolidine-5,8′-1-azabicyclo[2.2.2]octane]-2-one, N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide,5-morpholin-4-yl-pentanoic acid (4-pyridin-3-yl-phenyl)-amide, EVP-6124, EVP-4473, TC-6987, and MEM3454;
wherein the composition is in a pharmaceutically acceptable form provided in a single dosage form.
11. The method of claim 10 , wherein said administering step comprises administering the pharmaceutical composition to a human subject as a smoking cessation aid.
12. The method of claim 10 , wherein the agonist is N-[(2S,3S)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-2-carboxamide.
13. The method of claim 10 , wherein the nicotine is in the form of a free base, a salt, a complex, or a solvate.
14. The method of claim 10 , wherein the nicotine is nicotine polacrilex, nicotine free base, nicotine tartrate, or nicotine bitartrate.
15. The method of claim 10 , wherein one or both of the nicotine and the agonist are sorbed onto a porous particulate carrier.
16. The method of claim 15 , wherein the porous particulate carrier comprises microcrystalline cellulose.
17. The method of claim 10 , wherein the composition is in a form adapted for oral ingestion.
18. The method of claim 10 , wherein the composition is in the form of a gum, lozenge, tablet, spray or a pouch product.